Recurrent UTIs Worsen Kidney Transplant Outcomes

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Kidney transplant recipients who experience recurrent urinary tract infections are at increased risk of graft failure and death.
Kidney transplant recipients who experience recurrent urinary tract infections are at increased risk of graft failure and death.

Recurrent urinary tract infections (UTIs) are associated with poorer graft and patient outcomes compared with noncurrent UTIs, researchers reported.

In a retrospective study of 2469 kidney transplant recipients, Nicholas S. Britt, MD, and colleagues at Barnes-Jewish Hospital in St. Louis, Missouri, compared graft and patient outcomes and multidrug-resistance rates. Of these, 1835 (74.3%) had no UTIs, 465 (18.8%) had non-recurrent UTIs, and 169 (6.8%) had recurrent UTIs. Recipients with recurrent UTIs had 1.4-fold and 2-fold increased risk of graft failure than those with no UTIs, Dr Britt's group reported online in Nephrology Dialysis Transplantation (2017;32:1758-1766). Patients with recurrent UTIs had an 87% increase risk of death compared with those who had non-recurrent UTIs. In addition recurrent UTIs were more 49% more likely to be caused by multidrug-resistant Gram-negative bacteria.

The investigators defined recurrent UTIs as 2 or more UTIs in any 6-month period or 3 or more UTIs in any 12-month period.

Reference

Britt NS, Hagopian JC, Brennan DC, et al. Effects of recurrent urinary tract infections on graft and patient outcomes after kidney transplantation. Nephrol Dial Transplant. 2017;32:1758-1766. doi:10.1093/ndt/gfx237

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