Kidney Transplant Timing Matters Little to Pregnancy

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Live births occurred in 76% of pregnancies in the childhood transplant group and 77% of pregnancies in the adulthood transplant group.
Live births occurred in 76% of pregnancies in the childhood transplant group and 77% of pregnancies in the adulthood transplant group.

(HealthDay News) -- Pregnancy outcomes are similar for women who have received a kidney transplant, whether they were a child or an adult when they got their transplant, according to a new study published in the February issue of JAMA Pediatrics.

Researchers reviewed data on women in Australia and New Zealand who received a new kidney and got pregnant at least once between 1963 and 2012. There were 101 pregnancies among 66 women who had a childhood kidney transplant, defined as getting a transplant before they were 18. There were 626 pregnancies among 401 women who had an adulthood kidney transplant. 

At the time of pregnancy, those in the childhood transplant group were an average age of 25 with a functioning transplant for 10 years. Those in the adulthood transplant group were an average age of 31 with a functioning transplant for 6 years.

Live births occurred in 76% of pregnancies in the childhood transplant group and 77% of pregnancies in the adulthood transplant group. The researchers found that rates of preterm birth (less than 37 weeks pregnancy) were 45% in the childhood transplant group and 53% in the adulthood transplant group. 

The percentage of preterm babies who were small for their gestational age was 22% in the childhood transplant group and 10% in the adulthood transplant group. Rates of full-term babies who were small for gestational age were 57% in the childhood transplant group and 38% in the adulthood transplant group. Those rates were much higher than in the general population.

"This work has shown that outcomes for childhood transplant mothers are similar to outcomes for adulthood transplant mothers and should provide comfort to such mothers and their physicians that their early onset of kidney failure and longer period of post-transplant exposure to immunosuppression do not adversely affect their pregnancy outcomes," the authors write.

Source

  1. Wyld, M, et al. JAMA Pediatr. 2015;169(2):e143626; doi:10.1001/jamapediatrics.2014.3626.
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