Anticoagulants May Protect Transplanted Kidneys After Surgery

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An anticoagulant was found to preserve kidney function after transplantation, according to a recent study published in the British Journal of Surgery.

Researchers led by Thierry Hauet, MD, PhD, of the University of Poitiers in France wanted to observe the protective effects of anticoagulants (“blood thinners”) in transplanted organs, noting that such organs are deprived of normal blood flow initially after surgery which could lead to additional damage from clotting.

They tested fondaparinux in an experimental model of kidney transplantation and found that the anticoagulant was linked with improved kidney function immediately after surgery as well as several months after.

“This study demonstrates the benefits of anticoagulation therapy using new and original drugs at the time of organ collection,” said Dr. Hauet. “Such therapy could augment the pool of available organs and allow for the safe use of marginal organs, which have characteristics associated with poorer outcomes or come from donors with medical complexities.”

The new potential anticoagulation strategy could further aid current treatment protocols to limit tissue damage in transplant patients.

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An anticoagulant was found to preserve kidney function after transplantation.

Organs can become significantly damaged during transplantation, but a new article published in the BJS (British Journal of Surgery) offers a protective strategy that could keep them safe and allow them to function optimally after the procedure. When an organ is transplanted from a donor to a recipient, there is a period of time when the organ is deprived of normal blood flow.

While this in itself can cause tissue damage, additional damage may also occur when blood flow is restored to the organ due to a high risk of blood clotting. Investigators led by Thierry Hauet, MD, PhD, of the Institut National de la Santé et de la Recherche Médicale (INSERM), the University of Poitiers, and the Centre Hospitalier Universitaire (CHU) de Poitiers, in France, wondered whether anticoagulants or "blood thinners" might help protect transplant organs against these effects.

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