High BMI Predicts Adverse Transplant Outcomes

Increased body mass index (BMI) at kidney transplantation predicts adverse outcomes, a Canadian study found.

Simon P. Curran, MD, of Toronto General Hospital, University Health Network, and colleagues studied 1,151 kidney transplant recipients. Compared with patients who had a BMI of 20-24.9 kg/m2 at transplantation, those who had a BMI of 30-34.9 had a nearly twofold increased risk of delayed graft function, the investigators reported online ahead of print in Transplantation. Patients with a BMI of 35 or higher had 4.5-fold increased risk. 

In addition, a BMI of 35 or higher was associated with a 2.4-fold increased risk of biopsy-proven acute rejection, a 2.4-fold increased risk of death-censored graft failure, and a twofold increased risk of all-cause graft failure. The researchers found no significant association between BMI and death with graft function.

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