Kidneys From Octogenarian Donors Show Similar Survival

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Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the donor-organ pool.
Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the donor-organ pool.

(HealthDay News) — Graft survival is similar for recipients of kidneys from >80-year-old donors and donors aged ≤60 years, according to a study published online in the American Journal of Transplantation.

Piero Ruggenenti, MD, from the Clinical Research Centre for Rare Diseases Aldo e Cele Daccò in Bergamo, Italy, and colleagues compared graft survival for 37 recipients of 1 or 2 histologically evaluated kidneys from >80-year-old donors with 198 reference-recipients of nonhistologically evaluated single grafts from ≤60-year-old donors.

The researchers found that two recipients (5.4%) and 10 reference-recipients (5.1%) required dialysis over a median of 25 months (crude and donor age- and sex-adjusted hazard ratios, 1.55 [95% confidence interval, 0.34 to 7.12; P =.576] and 1.41 [95% confidence interval, 0.1 to 19.54; P =.798]). Similar outcomes were confirmed in shared frailty analyses in a 1-to-2 propensity score study comparing recipients with 74 reference-recipients matched by center, year, and donor and recipient sex and age. Over 84-month follow-up, serum creatinine was similar across groups. Recipients had shorter waiting times than reference-recipients and matched reference-recipients (7.5 vs 36 and 40 months, respectively; both P <.0001). Similar adverse events were seen across groups.

"Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the donor-organ pool and faster access to a kidney transplant, without increasing the risk of premature graft failure," the authors write.

Reference

  1. Ruggenenti P, Silvestre C, Boschiero L, et al. Long- term outcome of renal transplantation from octogenarian donors: A multicenter controlled study. Am J Transplant. 9 August 2017. doi: 10.1111/ajt.14459

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