In a small study, direct-acting prophylaxis against hepatitis C virus (HCV) appeared safe and well-tolerated in uninfected recipients of HCV+ kidneys.
1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for patients with kidney 
Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.
Patients who have a failed renal allograft removed prior to undergoing another kidney transplant may be at increased risk of losing the new allograft, according to a new review.
The living kidney donor candidate evaluation process can reveal serious undiagnosed medical problems.
1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD). 2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced quality of life, or mortality. 
Increased risks for ESRD, preeclampsia, although absolute risk of these outcomes remains low.
Standardized transplantation referral ratio shows most variation is due to within-facility characteristics.
Support, clear communication from health care team essential for improving donor comfort level.
Less than perfect older kidneys may still be suitable for transplantation.
Robotic-assisted kidney transplantation is associated with a low complication rate and excellent graft function, European study shows.
New findings suggest that national strategies have failed to correct racial/ethnic disparities in live donor kidney transplantation.
Decrease in excess risk of all-cause mortality from 1995 to 2013 for those with end-stage renal disease.
Altering the surface of an anti-CD31 antibody helps NPs administer therapeutics to ECs.
Data that shed light on the allograft decision process may ultimately help transplant teams navigate their expanding waiting lists.
In animal model, anti-CD47 monoclonal antibody group had decease in injury of renal allografts.
African-Americans less likely to be wait-listed; higher income positively associated with wait-listing.
Among kidney transplant recipients who died with a functioning graft, the cause of death was reported as unknown for 64% of them.
After adjusting for confounders, patients on intensive home hemodialysis and recipients of deceased-donor kidneys showed no significant difference in death risk
In a study 383 kidney transplant recipients, low levels of 25-hydroxyvitamin D were not associated with an increased risk of graft loss following transplantation.
Standardized incidence ratio peaked in patients who underwent transplantation in 1983-1987 period.
Key changes include new N category descriptors, more stage III subgroups, new M1D designation.
Limiting cold ischemia times could increase the use of renal allografts donated from patients after death from cardiovascular causes, researchers say.
Kidney transplant recipients who experience recurrent urinary tract infections are at increased risk of graft failure and death.
Hemodialysis patients had higher rates of infective endocarditis than peritoneal dialysis and kidney transplant patients.
Score for subscale of perceived seriousness for no reduction of salt intake higher in transplant patients.
Each 1-mg/dL increase in serum phosphorus among kidney transplant recipients is associated with 36% and 21% increased risk in graft failure and death, respectively.
Biopsy-guided allocation of kidneys from octogenarian donors permits further expansion of the donor-organ pool.
There was a correlation for later acceptance in the match-run with delayed graft function, but not with all-cause graft failure.
IdeS reduced or eliminated donor-specific antibodies and permitted HLA-incompatible transplantation.
Risk factors include older age, white race, and receiving a kidney from a living donor.
Increased risk of allograft loss, death for HIV-positive patients receiving protease inhibitor ART.
Most lower-quality kidneys also remained viable for nearly as long as the best kidneys, with 73.2% still working 5 years after transplant.
The researchers observed a narrowing of disparities in the average monthly transplantation rates with implementation of the new system.
Up to half of transplant patients might experience tertiary hyperparathyroidism.
Overall, recipients of diabetic donor kidneys had a 9% lower chance of dying compared with remaining on the waitlist.
During the observation period, the researchers found that 77.5%, 69.8%, and 91.4% of SOTRs were not up-to-date for colorectal, cervical, and breast cancer screening tests, respectively.
Early data from the study revealed this treatment effectively cleared hepatitis C from all of the patients.
NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.
In a study, obese transplant recipients with low muscle mass had an increased risk of death but not graft loss.
The incidence of NODAT was 33.8% among patients who switched to everolimus and 36.4% among those who stayed on calcineurin inhibitors.
Opportunistic viral and fungal infections or malignancies develop in 34% of kidney transplant recipients, but these complications do not affect patient or graft survival.
Highest level of opioid use in the year prior to transplantation was associated with a 45% and 28% increased risk of death and graft loss, respectively.
In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.
Post-transplant UTI rates were lower when cephalexin was added to SMX-TMP than when SMX-TMP was used alone (7.5% vs 25.8%), study finds.
Kidney transplant recipients who experienced an episode of bacteremia had double the risks of graft failure and death.
Older patients with a Charlson Comorbidity Index score below 5 had a higher 3-year survival rate than those with a score of 5 or higher (90% vs 76%).
High-KDPI kidneys can improve the likelihood of a functioning graft compared with waiting for a superior kidney.
Venous thromboembolism is associated with a 4.1-fold increased risk of death and a 2.3-fold increased risk of death-censored graft loss among kidney transplant recipients.
Risk factors include impaired renal function and inadequate hydration prior to contrast exposure.
Angioplasty plus stenting is associated with less residual stenosis and a lower restenosis rate compared with angioplasty alone.
Researchers report that matching deceased kidney donors and kidney recipients by cytomegalovirus serostatus optimizes high- and low-risk profiles.
Five-year graft survival rates among recipients of kidneys from living donors increased from 76.6% in 1985-1894 to 85.4% in 2009-2015.
The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.
In a study of renal transplant patients who received ureteral stents, ciprofloxacin did not lower the incidence of UTI compared with SMX-TMP.
Cinacalcet treatment may serve as a bridge to parathyroidectomy or as an alternative, researchers say.
Among 1734 childhood recipients, 289 developed cancer over a median follow-up of 13.4 years.
Graft failure risk was highest when a recipient of a kidney from a donor of the opposite sex was more than 66 pounds heavier than the donor.
Study supports transplant of kidneys into sensitized patients.
Hospitals that managed the most deceased donors were 1.5 times more likely to recover 4 or more transplantable organs than those that managed the least.
Acute ST-segment elevation myocardial infarction (STEMI) accounted for 29.3% of RTR admissions.
From 2015 to 2016, the number of organ transplants rose from 30,969 to 33,595; the number of kidney transplants increased from 17,878 to 19,061.
Investigators observed no difference in hemoglobin level between transplant recipients and non-transplant CKD patients starting hemodialysis.
Activation of latent HPV infections may contribute to the increased risk of HPV-related (pre)malignant lesions in female RTRs.
End-stage renal disease is nearly 1.9 times more likely to develop in donors with a body mass index of 30 kg/m2 or higher.
Similar survival rates seen whether organ comes from 50-year-old or octogenarian.
The researchers found that all patients treated for 12 and 24 weeks achieved sustained virologic response at 12 weeks after therapy ended.
Organs from CI-positive donors were associated with higher mortality.
While antiretroviral therapy has allowed HIV patients to undergo kidney transplantation, allograft rejection remains high in this group.
Fracture incidence within a year of transplant was 3 times lower among patients who had surgery from 2009 to 2011 vs 2004 to 2006.
Bone turnover markers increased following unilateral nephrectomy.
All recipients should have full-body skin evaluations after transplant surgery, regardless of ethnicity.
Therapy was associated with a significant improvement in bone mineral density at the lumbar spine and femoral neck.
Living kidney donor costs up with higher degree of allosensitization; also linked to obesity.
Guidelines for kidney recipients differ on frequency of cancer screenings.
Study reveals a significantly higher risk of a 50% or greater decline in eGFR and end-stage graft failure.
The availability of direct-acting antiviral drugs may enable eradication of hepatitis C virus and improve outcomes.
Major fractures included the proximal humerus, forearm, hip, and clinical vertebral fractures.
Study also links smoking with a decreased likelihood of receiving a kidney transplant.
Inhibition with http://www.renalandurologynews.com/transplantation/section/635/ occurs after virus entry but before DNA replication.
Recipients of kidneys from individuals who donated the organs after cardiac death are more likely to experience graft loss and delayed graft function.
Researchers highlighted the benefit of iPTH monitoring.
HIV retransplant recipients have increased risk of death and graft loss versus HIV re-KT patients
Possible reasons include malabsorption of immunosuppressive drugs and deposition of oxalate crystals in transplanted kidneys.
Rates of non-adherence to follow-up care and medication regimens also found to differ by race.
Some donors spend years on dialysis before being placed on the kidney transplant waiting list.
Each Hounsfield unit increase on CT is associated with a 7% decreased risk of death among waitlisted kidney transplant candidates.
Coronary artery disease before transplantation increases death risk by 77%, study finds.
An eGFR decline of at least 30% during the 6 to 24 months after kidney transplantation predicts a higher risk of graft loss.
In a study, viral infections occurred in 52.4% of patients with a BMI of 35 kg/m2 or higher compared with 37.1% of those with a lower BMI.
The 15-hour surgery took place in early May.
Deceased donor kidneys obtained on Friday or Saturday were 16% more likely to be discarded than transplanted, compared with organs gathered other days of the week.
Oral nicotinamide has been linked to nonsignificant reductions in new, non-melanoma skin cancers in renal transplant patients.
Nearly 28% of deceased-donor kidney transplants in the US were performed on the weekends.
Only this histologic variant occurs at a significantly higher incidence in renal allograft recipients than the non-transplant population.
At 24 months follow up, no difference was found in primary outcomes in those treated for asymptomatic bacteriuria.
Uninsured live kidney donors are more likely to have multiple health risk factors.
Increased likelihood of delayed graft function and graft loss observed in recipients of kidneys from donors older than 50 years.
Nearly 70% of survey respondents indicated that, if compensated, they would donate a kidney to anyone in need.
Survival rates are lower among patients who receive a deceased-donor kidney or remain on the transplant waiting list.
Renal and Urology News Articles
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)