Opioid Use Linked to Worse Outcomes in Kidney Transplant Patients

Opioid Use Linked to Worse Outcomes in Kidney Transplant Patients

Highest level of opioid use in the year prior to transplantation was associated with a 45% and 28% increased risk of death and graft loss, respectively.

Diabetes Increases Post-Transplant Mortality Risk

Diabetes Increases Post-Transplant Mortality Risk

In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.

Antibiotic Combo Found to Reduce Post-Transplant UTI Rate

Antibiotic Combo Found to Reduce Post-Transplant UTI Rate

Post-transplant UTI rates were lower when cephalexin was added to SMX-TMP than when SMX-TMP was used alone (7.5% vs 25.8%), study finds.

Bacteremia Worsens Kidney Transplant Outcomes

Bacteremia Worsens Kidney Transplant Outcomes

Kidney transplant recipients who experienced an episode of bacteremia had double the risks of graft failure and death.

CCI May Predict Outcomes Among Older Kidney Recipients

CCI May Predict Outcomes Among Older Kidney Recipients

Older patients with a Charlson Comorbidity Index score below 5 had a higher 3-year survival rate than those with a score of 5 or higher (90% vs 76%).

Accepting High-Risk Kidneys Is Better Than Waiting

Accepting High-Risk Kidneys Is Better Than Waiting

High-KDPI kidneys can improve the likelihood of a functioning graft compared with waiting for a superior kidney.

VTE Linked to Higher Death, Graft Loss Risk in Transplant Recipients

VTE Linked to Higher Death, Graft Loss Risk in Transplant Recipients

Venous thromboembolism is associated with a 4.1-fold increased risk of death and a 2.3-fold increased risk of death-censored graft loss among kidney transplant recipients.

Risk Factors for Contrast-Induced AKI in Transplant Patients ID'd

Risk Factors for Contrast-Induced AKI in Transplant Patients ID'd

Risk factors include impaired renal function and inadequate hydration prior to contrast exposure.

Stenting May Improve Transplant Renal Artery Stenosis Outcomes

Stenting May Improve Transplant Renal Artery Stenosis Outcomes

Angioplasty plus stenting is associated with less residual stenosis and a lower restenosis rate compared with angioplasty alone.

Kidney Donor-Recipient CMV Matching Is a Promising Strategy

Kidney Donor-Recipient CMV Matching Is a Promising Strategy

Researchers report that matching deceased kidney donors and kidney recipients by cytomegalovirus serostatus optimizes high- and low-risk profiles.

Living Kidney Donor Graft Survival Improving

Living Kidney Donor Graft Survival Improving

Five-year graft survival rates among recipients of kidneys from living donors increased from 76.6% in 1985-1894 to 85.4% in 2009-2015.

Obesity Ups Diabetes Risk Among Living Kidney Donors

Obesity Ups Diabetes Risk Among Living Kidney Donors

The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.

Cipro Not Better for UTI Prophylaxis After Transplant With Stent

Cipro Not Better for UTI Prophylaxis After Transplant With Stent

In a study of renal transplant patients who received ureteral stents, ciprofloxacin did not lower the incidence of UTI compared with SMX-TMP.

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

Cinacalcet treatment may serve as a bridge to parathyroidectomy or as an alternative, researchers say.

Higher Cancer Risk for Pediatric Kidney Recipients

Higher Cancer Risk for Pediatric Kidney Recipients

Among 1734 childhood recipients, 289 developed cancer over a median follow-up of 13.4 years.

Donor-Recipient Weight, Sex Mismatch Ups Graft Loss

Donor-Recipient Weight, Sex Mismatch Ups Graft Loss

Graft failure risk was highest when a recipient of a kidney from a donor of the opposite sex was more than 66 pounds heavier than the donor.

Pre-transplant Anti-donor Antibodies Linked With Better Kidney Survival

Pre-transplant Anti-donor Antibodies Linked With Better Kidney Survival

Study supports transplant of kidneys into sensitized patients.

High-Volume Hospitals Recover More Transplantable Organs Per Donor

High-Volume Hospitals Recover More Transplantable Organs Per Donor

Hospitals that managed the most deceased donors were 1.5 times more likely to recover 4 or more transplantable organs than those that managed the least.

Kidney Transplant Recipients Often Hospitalized With Acute MI

Kidney Transplant Recipients Often Hospitalized With Acute MI

Acute ST-segment elevation myocardial infarction (STEMI) accounted for 29.3% of RTR admissions.

Record Number of Transplants in 2016 Reported

Record Number of Transplants in 2016 Reported

From 2015 to 2016, the number of organ transplants rose from 30,969 to 33,595; the number of kidney transplants increased from 17,878 to 19,061.

Anemia Control Similar for Transplant Patients Re-entering Dialysis

Anemia Control Similar for Transplant Patients Re-entering Dialysis

Investigators observed no difference in hemoglobin level between transplant recipients and non-transplant CKD patients starting hemodialysis.

HPV Infection Increase Seen in Female Kidney Recipients

HPV Infection Increase Seen in Female Kidney Recipients

Activation of latent HPV infections may contribute to the increased risk of HPV-related (pre)malignant lesions in female RTRs.

Obesity Ups ESRD Risk Among Living Kidney Donors

Obesity Ups ESRD Risk Among Living Kidney Donors

End-stage renal disease is nearly 1.9 times more likely to develop in donors with a body mass index of 30 kg/m2 or higher.

Older Donor Kidneys Viable for Organ Donation

Older Donor Kidneys Viable for Organ Donation

Similar survival rates seen whether organ comes from 50-year-old or octogenarian.

Ledipasvir-Sofosbuvir OK for Transplant Recipients With Hepatitis C

Ledipasvir-Sofosbuvir OK for Transplant Recipients With Hepatitis C

The researchers found that all patients treated for 12 and 24 weeks achieved sustained virologic response at 12 weeks after therapy ended.

Coccidioidomycosis Ups Death Risk in Organ Recipients

Coccidioidomycosis Ups Death Risk in Organ Recipients

Organs from CI-positive donors were associated with higher mortality.

Kidney Transplantation Rejection Remains High With HIV

Kidney Transplantation Rejection Remains High With HIV

While antiretroviral therapy has allowed HIV patients to undergo kidney transplantation, allograft rejection remains high in this group.

Fewer Post-Transplant Fractures With Practice Changes

Fewer Post-Transplant Fractures With Practice Changes

Fracture incidence within a year of transplant was 3 times lower among patients who had surgery from 2009 to 2011 vs 2004 to 2006.

Kidney Donors Possibly at Risk for Bone Loss

Kidney Donors Possibly at Risk for Bone Loss

Bone turnover markers increased following unilateral nephrectomy.

Nonmelanoma Skin Cancer Risk Up in Organ Transplant Recipients

Nonmelanoma Skin Cancer Risk Up in Organ Transplant Recipients

All recipients should have full-body skin evaluations after transplant surgery, regardless of ethnicity.

Kidney Transplant Patients Benefit From Bisphosphonates

Kidney Transplant Patients Benefit From Bisphosphonates

Therapy was associated with a significant improvement in bone mineral density at the lumbar spine and femoral neck.

Donor, Recipient Factors Influence Kidney Transplant Costs

Donor, Recipient Factors Influence Kidney Transplant Costs

Living kidney donor costs up with higher degree of allosensitization; also linked to obesity.

Cancer Screening Guidelines for Transplant Recipients Need Improvement

Cancer Screening Guidelines for Transplant Recipients Need Improvement

Guidelines for kidney recipients differ on frequency of cancer screenings.

Post-Transplant Decrease in Kidney Graft Size Predicts Worse Outcomes

Post-Transplant Decrease in Kidney Graft Size Predicts Worse Outcomes

Study reveals a significantly higher risk of a 50% or greater decline in eGFR and end-stage graft failure.

Hepatitis C in CKD: Challenges and Opportunities

Hepatitis C in CKD: Challenges and Opportunities

The availability of direct-acting antiviral drugs may enable eradication of hepatitis C virus and improve outcomes.

Fracture Risk Factors in Transplant Patients ID'd

Fracture Risk Factors in Transplant Patients ID'd

Major fractures included the proximal humerus, forearm, hip, and clinical vertebral fractures.

Smoking Hikes Mortality Risk Among Dialysis Patients

Smoking Hikes Mortality Risk Among Dialysis Patients

Study also links smoking with a decreased likelihood of receiving a kidney transplant.

Emetine May Treat Cytomegalovirus Infection

Emetine May Treat Cytomegalovirus Infection

Inhibition with http://www.renalandurologynews.com/transplantation/section/635/ occurs after virus entry but before DNA replication.

Deceased-Donor Age Affects Kidney Transplant Outcomes

Deceased-Donor Age Affects Kidney Transplant Outcomes

Recipients of kidneys from individuals who donated the organs after cardiac death are more likely to experience graft loss and delayed graft function.

Subtotal Parathyroidectomy Safe, Effective, Study Finds

Subtotal Parathyroidectomy Safe, Effective, Study Finds

Researchers highlighted the benefit of iPTH monitoring.

Worse Re-transplant Outcomes for HIV Positive Patients

Worse Re-transplant Outcomes for HIV Positive Patients

HIV retransplant recipients have increased risk of death and graft loss versus HIV re-KT patients

Bariatric Surgery May Increase Risk of Renal Allograft Loss

Bariatric Surgery May Increase Risk of Renal Allograft Loss

Possible reasons include malabsorption of immunosuppressive drugs and deposition of oxalate crystals in transplanted kidneys.

Patient Non-Adherence Predicts Worse Kidney Transplant Outcomes

Patient Non-Adherence Predicts Worse Kidney Transplant Outcomes

Rates of non-adherence to follow-up care and medication regimens also found to differ by race.

Prior Living Kidney Donors With ESRD May Not Get Timely Transplants

Prior Living Kidney Donors With ESRD May Not Get Timely Transplants

Some donors spend years on dialysis before being placed on the kidney transplant waiting list.

Muscle Density Predicts Death Risk in Patients Waiting for a Kidney

Muscle Density Predicts Death Risk in Patients Waiting for a Kidney

Each Hounsfield unit increase on CT is associated with a 7% decreased risk of death among waitlisted kidney transplant candidates.

Post-Kidney Transplant Mortality Linked to Pre-Existing Heart Disease

Post-Kidney Transplant Mortality Linked to Pre-Existing Heart Disease

Coronary artery disease before transplantation increases death risk by 77%, study finds.

Long-Term Kidney Transplant Outcomes Linked to 30% eGFR Decline

Long-Term Kidney Transplant Outcomes Linked to 30% eGFR Decline

An eGFR decline of at least 30% during the 6 to 24 months after kidney transplantation predicts a higher risk of graft loss.

Morbid Obesity Ups Viral Infection Risk After a Kidney Transplant

Morbid Obesity Ups Viral Infection Risk After a Kidney Transplant

In a study, viral infections occurred in 52.4% of patients with a BMI of 35 kg/m2 or higher compared with 37.1% of those with a lower BMI.

Surgeons Perform First Penile Transplant in the US

Surgeons Perform First Penile Transplant in the US

The 15-hour surgery took place in early May.

Weekend Effect Observed for Donor Kidney Discard

Weekend Effect Observed for Donor Kidney Discard

Deceased donor kidneys obtained on Friday or Saturday were 16% more likely to be discarded than transplanted, compared with organs gathered other days of the week.

Oral Nicotinamide Safe for Renal Transplant Recipients

Oral Nicotinamide Safe for Renal Transplant Recipients

Oral nicotinamide has been linked to nonsignificant reductions in new, non-melanoma skin cancers in renal transplant patients.

Weekend Transplant Outcomes Not Worse

Weekend Transplant Outcomes Not Worse

Nearly 28% of deceased-donor kidney transplants in the US were performed on the weekends.

Renal Transplant Patients At Higher Risk of Papillary RCC

Renal Transplant Patients At Higher Risk of Papillary RCC

Only this histologic variant occurs at a significantly higher incidence in renal allograft recipients than the non-transplant population.

No Routine Antimicrobial Use for Post-Transplant Asymptomatic Bacteriuria

No Routine Antimicrobial Use for Post-Transplant Asymptomatic Bacteriuria

At 24 months follow up, no difference was found in primary outcomes in those treated for asymptomatic bacteriuria.

Some Live Kidney Donors Uninsured

Some Live Kidney Donors Uninsured

Uninsured live kidney donors are more likely to have multiple health risk factors.

Live-Donor Kidney Transplant Outcomes Worse with Longer CIT

Live-Donor Kidney Transplant Outcomes Worse with Longer CIT

Increased likelihood of delayed graft function and graft loss observed in recipients of kidneys from donors older than 50 years.

Paying Donors May Encourage Kidney Donation

Paying Donors May Encourage Kidney Donation

Nearly 70% of survey respondents indicated that, if compensated, they would donate a kidney to anyone in need.

Kidneys from Incompatible Live Donors Offer a Survival Advantage

Kidneys from Incompatible Live Donors Offer a Survival Advantage

Survival rates are lower among patients who receive a deceased-donor kidney or remain on the transplant waiting list.

Hepatitis E Infection From Plasma Exchange

Hepatitis E Infection From Plasma Exchange

Transmission of HEV through plasma exchange for acute humoral rejection after kidney transplant.

Belatacept Improves Kidney Transplant Outcomes

Belatacept Improves Kidney Transplant Outcomes

At 7 years after kidney transplantation, belatacept recipients had lower risks of death and graft loss than those treated with cyclosporine.

Risk of Cancer Death Up for Organ Recipients

Risk of Cancer Death Up for Organ Recipients

Cancer second leading cause of death in solid-organ transplant recipients.

Any Renal Function Decline in Living Kidney Donors a Cardiac Risk

Any Renal Function Decline in Living Kidney Donors a Cardiac Risk

Increased left ventricular mass found in donors with even mild decreases in renal function.

PSA Screening May Harm ESRD Patients Awaiting Transplant

PSA Screening May Harm ESRD Patients Awaiting Transplant

Screening not linked to improved patient survival after transplant; may delay time to listing, transplant.

Racial/Ethnic Disparities in Home Dialysis Outcomes Identified

Racial/Ethnic Disparities in Home Dialysis Outcomes Identified

Blacks undergoing PD or home HD and Hispanics undergoing PD are less likely than their white counterparts to receive a kidney transplant.

Small Prostates Predict More Severe BOO Symptoms

Small Prostates Predict More Severe BOO Symptoms

The risk of bladder outlet obstruction increased 34% per unit increase in serum PSA and decreased 23% per unit increase in maximal flow rate.

Some Discarded Higher-Risk Kidneys May Be Transplantable

Some Discarded Higher-Risk Kidneys May Be Transplantable

Just over half of kidneys from deceased ECD/DCD donors are not used, study finds.

Artificial Kidney Technology Moves Forward

Artificial Kidney Technology Moves Forward

If ESRD patients face increasing difficulty getting a kidney transplant in coming years, they may see an artificial kidney as the next best alternative.

ACE Inhibitors May Not Benefit Transplant Patients With Proteinuria

ACE Inhibitors May Not Benefit Transplant Patients With Proteinuria

In a study, ramipril was not significantly better than placebo in preserving renal function in kidney transplant recipients.

ESRD and Treatments May Raise Cancer Risk

ESRD and Treatments May Raise Cancer Risk

Dialysis, organ transplant may increase odds for certain types of cancer.

Hepatitis, CMV More Common in Commercial Transplants

Hepatitis, CMV More Common in Commercial Transplants

Overall one- and ten-year survival rates of the transplanted organs in commercial recipients compared with controls were 91% and 22% vs. 98% and 44%.

Peritoneal Dialysis Patients May Have Better Post-Transplant Survival

Peritoneal Dialysis Patients May Have Better Post-Transplant Survival

Meta-analysis suggests a 9% decreased 5-year mortality risk associated with pre-transplant peritoneal dialysis versus hemodialysis.

Iron Deficiency Ups Mortality in Renal Transplant Recipients

Iron Deficiency Ups Mortality in Renal Transplant Recipients

The association is independent of anemia, according to researchers.

Increasing Antibiotic Resistance Plagues Surgery, Chemo

Increasing Antibiotic Resistance Plagues Surgery, Chemo

10% rise in antibiotic resistance would lead to 2,100 more deaths, 40,000 more infections yearly.

Safety-Net Hospitals Have Higher Costs, Worse Outcomes

Safety-Net Hospitals Have Higher Costs, Worse Outcomes

Found to have higher mortality, readmission, surgical costs after controlling for patient factors.

LVH Regression Improves Outcomes in Renal Transplant Recipients

LVH Regression Improves Outcomes in Renal Transplant Recipients

Reduction in left ventricular hypertrophy predicts a decreased long-term risk of death and cardiovascular events, study finds.

Low Post-Transplant Magnesium Ups Risk of New-Onset Diabetes

Low Post-Transplant Magnesium Ups Risk of New-Onset Diabetes

Hypomagnesemia after a kidney transplant is associated with a 58% increased risk of new-onset diabetes.

BK Virus Screening in Transplant Patients May Be Suboptimal

BK Virus Screening in Transplant Patients May Be Suboptimal

Researchers find an association between late-onset BK virus nephropathy and less adherence to screening guidelines.

Infected Kidney Donors Raise Delayed Graft Function Risk

Infected Kidney Donors Raise Delayed Graft Function Risk

Kidneys from blood culture positive donors are not associated with graft and patient survival, however.

Reduced-Dose Tacrolimus, Everolimus Cut CMV Infection

Reduced-Dose Tacrolimus, Everolimus Cut CMV Infection

Findings in de novo kidney recipients receiving no pharmacologic CMV prophylaxis.

Surgeons Perform Well Despite Late Night and Early Morning Operations

Surgeons Perform Well Despite Late Night and Early Morning Operations

Review indicates that doctors who operate the night before another surgery do well.

Greater Melanoma Risks Found Among Transplant Recipients

Greater Melanoma Risks Found Among Transplant Recipients

They have double the risk of invasive melanoma and triple the risk of dying from it.

Music Aids Patient Recovery from Surgery

Music Aids Patient Recovery from Surgery

Patients who listened to music had less pain, anxiety, and analgesia use after their operations, compared with patients receiving routine care or non-drug interventions.

Few Referrals for Transplant Evaluation Among Dialysis Patients

Few Referrals for Transplant Evaluation Among Dialysis Patients

Findings among end-stage renal disease patients initiating dialysis in Georgia.

Predictors of ECD Kidney Transplant Long-Term Outcomes Identified

Predictors of ECD Kidney Transplant Long-Term Outcomes Identified

The main independent determinants are circulating donor-specific anti-HLA antibody and cold ischemia time.

Organ Donation Rates Mostly Unaffected by State Policies

Organ Donation Rates Mostly Unaffected by State Policies

From 1988 to 2010, establishment of organ donation registries, tax incentives, and paid leave have had no significant effect.

Kidney Transplant Outcomes Better If Donors Are Kept in Hypothermia

Kidney Transplant Outcomes Better If Donors Are Kept in Hypothermia

Risk of delayed graft function is reduced when donors are maintained at a temperature of 93.2° to 95° F prior to kidney harvesting after death.

BMI Doesn't Affect Kidney Transplant Survival

BMI Doesn't Affect Kidney Transplant Survival

No difference between defined BMI bands in patient or graft survival for transplanted patients.

Post-Transplant UTI Risk Factors Identified

Post-Transplant UTI Risk Factors Identified

Female kidney recipients have a nearly 7-fold higher risk of UTI than their male counterparts.

Steroid Withdrawal May Not Prevent Post-transplant Diabetes

Steroid Withdrawal May Not Prevent Post-transplant Diabetes

Limited effect among adult patients during 5 years following kidney transplantation.

Living Kidney Donation Relatively Safe

Living Kidney Donation Relatively Safe

Ongoing study suggests that renal function continues to increase after donation but decreases in donation-eligible controls.

Nocturia, Reassurance Prompt Men to Seek Medical Care

Nocturia, Reassurance Prompt Men to Seek Medical Care

Overall, men with LUTS showed remarkably poor knowledge about their symptoms.

Laparoscopically Harvesting Right Kidneys from Living Donors Safe

Laparoscopically Harvesting Right Kidneys from Living Donors Safe

Donor and recipient outcomes are similar to those associated with laparoscopic removal of left donor kidneys.

High n-3 PUFA Intake Improves Survival After Kidney Transplantation

High n-3 PUFA Intake Improves Survival After Kidney Transplantation

Highest versus lowest intake associated with a 67% and 88% lower risk of all-cause and cardiovascular mortality, respectively.

Paying Donors May Help Organ Shortage

Paying Donors May Help Organ Shortage

It's time to reward people willing to save a stranger, researchers say.

Organ Donation Rates in the United States

Organ Donation Rates in the United States

While whites more likely to donate, report found race not the only driving factor.

Stroke Risk Lower with Kidney Transplants vs. Dialysis

Stroke Risk Lower with Kidney Transplants vs. Dialysis

Their risk of a stroke was 46% lower than that of dialysis patients.

Slow Adoption of HIV-Positive Organ Donations

Slow Adoption of HIV-Positive Organ Donations

Although ban was lifted on such surgeries in 2013, none have taken place, researchers say.

Transplant-Related Costs Incurred by Living Kidney Donors

Transplant-Related Costs Incurred by Living Kidney Donors

The researchers found that 96% of donors reported one or more direct costs, totaling $101,484 (mean $523).

Discharge Disposition Affects Transplant Patient Readmission Risk

Discharge Disposition Affects Transplant Patient Readmission Risk

Patients discharged with home health or to a skilled nursing facility also were more likely to be readmitted.

Race Gap in Kidney Transplant Outcomes Narrows Dramatically

Race Gap in Kidney Transplant Outcomes Narrows Dramatically

At the end of a 22-year study period, the 1- and 3-year risk of graft loss did not differs significantly between black and white recipients.

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