Biopsies are of little value in determining overall risk of delayed organ function or even premature organ failure, researcher says.
Immunologic mismatch may no longer be a barrier between living kidney donors and recipients.
By age 80 years, the estimated lifetime risk of ESRD was 90 per 10,000 live donors compared with 326 per 10,000 in the general population.
Sitagliptin was well tolerated and it significantly increased insulin secretion and reduced glucose levels.
A new study is suggesting there is substantial geographic variation in deceased donor kidney waiting times.
Levels above 500 ng/mL predicted higher incidence rates of infections overall as well as bacterial and bloodstream infections.
Renal tissue could one day be created that would be functional as well as completely immunocompatible.
HIV-1 was found in podocytes or tubular cells of renal allografts in recipients who did not have detectable plasma levels of the virus.
As a venue for presenting important research on kidney disease to the world, Kidney Week never disappoints.
A new study from University of Illinois researchers suggests that it may be possible to increase kidney donation through a multiple-message campaign.
Children who undergo solid organ transplantation may have a high risk of developing kidney disease, according to a new national study.
Increasing age and receipt of a deceased-donor kidney were among risk factors for death from infection.
Complications and hospital lengths of stay after kidney donation declined from 10.1% and a mean 3.7 days, respectively.
In a study, only 8% of readmissions within 30 days of discharge met preventability criteria.
A new study has looked at the health of kidney donors and turned up some rather interesting findings in terms of short-term health risks.
'Even 100 days out the risk is still high and it is still going higher,' researcher says.
Researchers evaluated sulfamethoxazole-trimethoprim single-strength twice-weekly in abdominal organ transplant patients.
Presence of complement-binding donor-specific antibodies increases risk of graft loss.
High risker of biopsy-proven acute rejection and death-censored graft failure observed in patients with a BMI of 35 kg/m2 or greater.
Even after five years on the drug, patients continue to have improved renal function compared with patients receiving cyclosporine A.
Cidofovir cleared cytomegalovirus that was resistant to ganciclovir.
Patients who receive their first kidney transplant at ages 14-16 years appear to be at increased risk for transplant failure.
Donors had a decrease in GFR and an increase in parathyroid hormone and uric acid six months after nephrectomy.
At one-year post-transplant, the risk of death was reduced by 66% or more in transplant recipients with a BMI below 40, but was reduced by only 48% in recipients with a BMI of 40 or higher
Severe fluid overload in patients with advanced CKD increases by threefold the likelihood of initiation of renal replacement therapy.
Robotic kidney transplants may significantly improve outcomes in obese patients.
Social media is playing a significant role in organ donation registration.
A study shows that with appropriate screening and selection, kidney transplantation can be performed successfully in octogenarians.
Spanish researchers have completed a large study showing that influenza vaccination just one month post-transplantation are safe.
Support for altruistic kidney donation appears to have more than doubled since 2001 in the United States.
Patients' one-year survival expectations more accurate than that of their nephrologist
Death risk increased by 55% if patients are rehospitalized within 30 days of kidney transplantation.
A study showed that the cost of immunosuppressive drugs for transplant recipients has declined substantially.
Angela Webster, MBBS, talks about why only certain patients should be screened for cancer post-transplant.
A number of single-center studies show that living kidney donation is associated with minimal morbidity and mortality.
Allograft function at one year post-transplant is more likely to be low if the donors are small.
Study finds a 60% increased likelihood of being hospitalized within 30 days of kidney transplant-related discharge.
Renal function improves over time in donors, declines with chronic kidney disease.
Reasons may include increasing prevalence of diabetes and obesity, economic disincentives, and transplant center oversight.
Systolic blood pressure of 160 mm Hg or higher raised death-censored graft loss risk twofold.
New findings could explain, at least in part, why live kidney donation has stagnated in the U.S.
Persistent need for dialysis at discharge increased the likelihood of readmission nearly threefold, study finds.
Plasma vitamin D levels increased to greater than 50 nmol/L in 80% of patients.
Recipients of kidneys from smokers are twice as likely to die as patients who get kidneys from nonsmokers.
From 2004 to 2010, the median fall in eGFR in the first year after donation grew significantly from 23.3 to 31.9 mL/min/1.73 m2.
Delayed graft function in patients aged 70 and older increased their death risk twofold.
The annual per-patient cost for kidney transplant recipients dropped from $33,040 in 2007 to $18,746 in 2011.
Cytomegalovirus viremia less likely with 200 rather than 100 days of valganciclovir after kidney transplantation.
Study characterizes cytomegalovirus infections in a large population of kidney transplant recipients.
In a study, vitamin D and calcium supplementation for one year made no difference in bone mineral density.
At-risk transplant recipients, however, have a lower risk of graft failure with prophylaxis than preemptive therapy.
Even blood pressure not considered hypertensive may reflect latent risk for adverse outcomes.
Improvements in immunosuppressive therapy have resulted in longer survival of kidney transplants, but they also may increase malignancies.
The objective is to eliminate the need for donors to travel to recipients' transplant centers to undergo nephrectomy.
Patients with ESRD may now have a tool to help them decide on kidney transplantation.
Greater efforts may be needed to educate patients with end-stage renal disease, especially African Americans.
Easing stenosis in transplanted renal arteries improves kidney function.
Paired kidney exchanges are not as popular because there is no way for insurance companies to determine which company pays for which donor's surgery.
Researchers recommend BK virus screening for all kidney transplant recipients.
Study implicates low diastolic and high systolic pressure immediately after kidney transplantation.
Five-year mortality is lower among PCa patients who receive a transplant rather than stay on dialysis.
In a study, 44% of neoplasias detected within a year of transplantation may have been present prior to surgery.
Patients needing dialysis for at least two weeks after receiving a kidney had lower eGFR at one year.
Low serum magnesium found to increase the risk by nearly 50%.
Recipients older than 65 had rates of delayed graft function and graft loss at one year similar to those of younger recipients.
No anti-HLA antibodies developed following administration of the influenza A/H1N1 vaccine.
A new study shows that islet transplantation for type-1 diabetics achieves insulin independence and reverses progression.
Graft loss risk is the same as with kidneys from brain-death donors.
Recipients of relatively large kidneys have higher eGFRs up to five years post-transplant.
Altruistic nondirected donors triggered nearly five transplants, more if the donors were blood type O.
Cytomegalovirus exposure prior to transplantation independently increases the risk for atherosclerotic events by 80%.
In a recent study researchers examined transplant outcomes in patients with lupus nephritis who had no clinical evidence of disease in the year prior.
Lupus nephritis patients can be good candidates if their disease is quiescent for at least one year prior to surgery.
Nuclear stress testing accounted for most of the radiation kidney transplant patients receive during the pretransplant evaluation.
A quality index that uses a simple formula allows comparisons of different transplant centers.
Pre-existing diabetes is associated with significantly lower graft and patient survival.
Women taking tacrolimus who wish to breastfeed after appropriate counseling should not be discouraged from doing so.
Survival rates for recipients of an organ from smokers and nonsmokers were 85% and 90.7% at five years and 67.4% and 76.5% at 10 years, respectively.
More than 95,000 individuals are on the kidney transplant waiting list in the United States.
Obese individuals often are rejected as renal transplant candidates in large part because of their increased risk for surgical complications and adverse outcomes.
The incidence of AKI requiring dialysis is now higher than the incidence of ESRD requiring dialysis or transplant.
A German study found that living kidney donation is safe and most donors report that they would donate again.
It also results in high patient and graft survival rates.
A new study suggests that individuals with pre-diabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
A central body fat distribution, as measured by waist-to-hip ratio, is a strong and independent predictor of allograft failure in renal transplant recipients.
A promising hybrid device that works from the inside to provide renal functions beyond dialysis 24 hours a day, seven days a week, has the potential to change a lot of lives.
The Cleveland Clinic has initiated the collection and storage of biospecimens from kidney and pancreas transplant recipients.
Increasing intake of fruits and vegetables and reducing intake animal protein may correct acid-base imbalance.
Australian researchers have found that renal transplantation may be the best treatment option for improving quality of life among patients with late-stage CKD.
More than 100,000 patients are on the kidney transplant waiting list and the increasing number of patients without living donor options underscore why it is important to decrease the discard rate of deceased donor kidneys available for transplantation.
Single-port kidney removal through the belly button may boost living-donor satisfaction.
Nearly half of kidney recipients in living donor transplant chains are minorities.
Renal transplant recipients who use of PPIs and MMF in the first year after transplantation may be at increased risk for allograft acute rejection.
Kidney transplant recipients who resume steroid treatment after early withdrawal from steroids following transplant surgery are at increased risk for new-onset diabetes (NODAT) and morbid obesity.
Everolimus may be useful as rescue therapy for chronic allograft nephropathy (CAN) and after onset of acute rejection.
Researchers have confirmed previously identified recipient risk factors for early renal graft loss.
Dual kidney transplants (DKT), in which transplant patients receive both of a donor's kidneys, have outcomes similar to those of recipients of expanded criteria donor (ECD) kidneys.
Patients with a failing kidney transplant are significantly less likely to receive vascular access surgery prior to starting HD than patients with advanced CKD.
Acute rejection significantly increases the likelihood of renal allograft loss regardless of when it occurs.
Low diastolic blood pressure (BP) before, and low systolic BP after, hemodialysis sessions are associated with a reduced risk of death following renal transplantation.