Statins Show Protective Effect Against Acute Kidney Injury

Share this article:
Statins Show Protective Effect Against Acute Kidney Injury
Statins Show Protective Effect Against Acute Kidney Injury

Initiating a statin prior to coronary artery bypass grafting (CABG) surgery may modestly reduce the risk of acute kidney injury (AKI) post-CABG, especially in patients less than 65 years old, researchers reported in The American Journal of Cardiology (2013;111:823-828).

J. Bradley Layton, PhD, of University of North Carolina at Chapel Hill, and colleagues used an epidemiological approach to estimate the effect of initiating statin pre-operatively on AKI after CABG.

Of the 17,077 CABG patients identified, post-CABG AKI developed in 3.4% of patients who started statin therapy preoperatively and 6.2% of patients who did not. After adjusting for confounders, statin use was associated with a 22% decreased risk of AKI in the study population overall, a 38% decreased risk among patients younger than 65, and a 9% decreased risk among those aged 65 and older.

"Our study supports the hypothesis that prescribing a statin before CABG in those not already receiving statin therapy may modestly attenuate the incidence of post-CABG AKI, particularly among younger patients," the authors wrote.

Share this article:
You must be a registered member of RUN to post a comment.

More in Acute Kidney Injury

Stroke Risk Higher in Patients Who Recover from AKI

Stroke Risk Higher in Patients Who Recover from ...

Taiwan study reveals a 25% increased risk of stroke among patients who recover from dialysis-requiring acute kidney injury.

Statins May Lower Risk of Contrast-Induced AKI

Statins May Lower Risk of Contrast-Induced AKI

Meta-analysis reveals a 46% decreased risk of contrast-induced acute kidney injury in patients undergoing coronary catheterization.

Where AKI Develops Affects Death Risk

Where AKI Develops Affects Death Risk

Patients are more likely to die if their acute kidney injury was acquired in the hospital rather than in the community.