Should the usual threshold for prostate biopsy be lowered from 4.0 to 2.5 ng/mL for healthy men with a life expectancy of well over 10 years?

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The National Cancer Institute estimated that 240,890 men would be diagnosed with prostate cancer in the United States in 2011. Many clinicians believe the disease is being overdiagnosed and overtreated, yet some researchers have advocated decreasing the PSA threshold for prostate biopsy from the conventional 4.0 ng/mL to 2.5 ng/mL in an attempt to pick up prostate cancers that are now being missed. Critics say this could exacerbate the problem of overdiagnosis and lead to even more men being treated unnecessarily.

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