Secondary Hyperparathyroidism

Low Protein Diet With Keto Analogues May Prevent SHPT

Low Protein Diet With Keto Analogues May Prevent SHPT

Dialysis patients treated with a low protein diet with keto analogues had lower levels of parathyroid hormone than those on a normal diet, meta-analysis shows.

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

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By the third month of treatment, 59% of etelcalcetide recipients had reached target iPTH levels of 60 to 240 pg/mL compared with just 1.3% of placebo recipients.

CKD Patients Frequently Re-hospitalized After Parathyroidectomy

CKD Patients Frequently Re-hospitalized After Parathyroidectomy

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Parathyroidectomy for hyperparathyroidism in CKD patients is associated with a 30-day readmission rate of 17.2%.

Etelcalcetide Shows Efficacy, Safety Over 52 Weeks

Etelcalcetide Shows Efficacy, Safety Over 52 Weeks

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By 52 weeks, 87.5% of patients had reached an intact parathyroid hormone target range of 60 to 240 pg/mL.

Expert Panel: Calcifediol Possibly a Better Option for SHPT

Expert Panel: Calcifediol Possibly a Better Option for SHPT

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Calcifediol is possibly more effective at alleviating 25(OH)D deficiency and reducing parathyroid hormone compared with other nutritional vitamin D therapies.

Total Parathyroidectomy Procedures Similarly Efficacious

Total Parathyroidectomy Procedures Similarly Efficacious

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Surgical complications and symptom improvement, for example, did not differ significantly between total parathyroidectomy with and without autotransplantation.

Low Vitamin D, High PTH Up Mortality Risk in Early CKD

Low Vitamin D, High PTH Up Mortality Risk in Early CKD

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The risk for premature death increased by 62% and 42% for stage 3 CKD patients with vitamin D deficiency and elevated parathyroid hormone levels, respectively.

Parathyroidectomy Associated With Morbidity, Mortality

Parathyroidectomy Associated With Morbidity, Mortality

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Single-center study reveals a hospitalization rate of 14% following total parathyroidectomy without autotransplantation.

Efficacy of Paricalcitol vs Other VDRAs Unclear

Efficacy of Paricalcitol vs Other VDRAs Unclear

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Meta-analysis shows comparable efficacy in lowering iPTH, but analyses of patient-centered outcomes such as mortality and cardiovascular death were not possible.

Researchers: Iron-based Binders Best for Hyperphosphatemia

Researchers: Iron-based Binders Best for Hyperphosphatemia

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Of 7 phosphate binders, iron-based agents were optimal when efficacy and safety are considered.

Most Patients Prefer Medication to Surgery for SHPT

Most Patients Prefer Medication to Surgery for SHPT

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New survey shows that out-of-pocket costs are a major concern.

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

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Bone mineral density in the lumbar spine and femoral neck increased over time in hemodialysis patients who underwent total parathyroidectomy without autotransplantation.

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

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SHPT in those aged 65 years or older is associated with lower eGFR, low levels of 25-hydroxyvitamin D, and use of furosemide.

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

High Post-op iPTH Linked With Increased Mortality in SHPT

High Post-op iPTH Linked With Increased Mortality in SHPT

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The risk of death more than tripled with iPTH levels above 600 pg/mL at 1 week after surgery.

Total PTx Without Autotransplantation May Improve Outcomes

Total PTx Without Autotransplantation May Improve Outcomes

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Meta-analysis reveals a lower risk of recurrence and persistence of SHPT when total parathyoidectomy is performed without transplanting parathyroid tissue.

Guidelines for CKD Mineral and Bone Disorder Updated

Guidelines for CKD Mineral and Bone Disorder Updated

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Among other changes, the new KDIGO guidelines highlight the potential dangers of hypercalcemia.

Hip Fracture Rates Falling Among ESRD Patients

Hip Fracture Rates Falling Among ESRD Patients

From 2003 to 2011 there was a 26.7% decrease in in-hospital mortality rate after hip fracture.

Review Supports Sodium Thiosulfate Use for Calciphylaxis

Review Supports Sodium Thiosulfate Use for Calciphylaxis

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Patients often received sodium thiosulfate with other therapies.

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

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Typically, about 2% to 20% of SHPT patients experience recurrence or persistence after conventional parathyroidectomy procedures, likely due to residual parathyroid tissue.

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

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In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.

Cardiothoracic Ratio Predicts Mortality in SHPT Patients

Cardiothoracic Ratio Predicts Mortality in SHPT Patients

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Higher CTR was associated with greater risks of death from cardiovascular disease and other causes.

Cinacalcet May Lower Death Risk in Dialysis Subgroups

Cinacalcet May Lower Death Risk in Dialysis Subgroups

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Researchers found lower all-cause mortality for cinacalcet-treated patients concomitantly treated with vitamin D and phosphate binders, for example.

Surgery More Effective for Post-Transplant Hyperparathyroidism

Surgery More Effective for Post-Transplant Hyperparathyroidism

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Up to half of transplant patients might experience tertiary hyperparathyroidism.

Residual Kidney Function Predicts Mortality in CKD-MBD

Residual Kidney Function Predicts Mortality in CKD-MBD

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In a study of hemodialysis patients, mortality risk increased along with phosphorus level, particularly among patients with higher residual renal urea clearance.

High-Volume Surgeons Improve Parathyroidectomy Outcomes

High-Volume Surgeons Improve Parathyroidectomy Outcomes

The researchers found that patients of high-volume surgeons had a lower rate of vocal cord paralysis compared to patients of low-volume surgeons.

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

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At 18 months, PTH levels were within target for 67% and 68% of participants who initiated etelcalcetide at 2.5 mg and 5 mg, respectively.

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

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Nearly twice as many patients achieved the target phosphorus range after a year of taking the phosphate binder, regardless of iPTH level.

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

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Cinacalcet treatment may serve as a bridge to parathyroidectomy or as an alternative, researchers say.

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