Secondary Hyperparathyroidism

SHPT May Predict Left Ventricular Diastolic Dysfunction

SHPT May Predict Left Ventricular Diastolic Dysfunction

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iPTH significantly correlated with measures of diastolic dysfunction in patients with non-dialysis chronic kidney disease.

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

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Patients with high alkaline phosphatase prior to PTx should be treated aggressively after surgery to prevent postoperative hypocalcemia, researchers conclude.

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

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In 2 studies, parathyroid hormone (PTH) values 20 minutes after parathyroidectomy predicted PTH levels for 5 years.

High, Low Values of CKD-MBD Markers Linked With Mortality

High, Low Values of CKD-MBD Markers Linked With Mortality

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In a study, intact parathyroid hormone levels below 60 and above 1500 pg/mL were associated with nearly double the risk of all-cause mortality.

Ethanol Ablation Therapy Feasible for SHPT

Ethanol Ablation Therapy Feasible for SHPT

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In a small study, more than half of patients with secondary hyperparathyroidism had a greater than 25% drop in parathyroid hormone levels following ethanol injection therapy.

SHPT Highly Prevalent Among Diabetic Nephropathy Patients

SHPT Highly Prevalent Among Diabetic Nephropathy Patients

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Nearly 86% of diabetic nephropathy patients from an Egyptian outpatient center had elevated iPTH levels.

Hypocalcemia Common After Cinacalcet Initiation

Hypocalcemia Common After Cinacalcet Initiation

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Hypocalcemia developed in 58.3% of study participants within the first 16 weeks and, in most cases, resolved within 14 days with no changes in treatment.

Parathyroidectomy for SHPT Improves Quality of Life

Parathyroidectomy for SHPT Improves Quality of Life

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Patients reported less skin itching, joint pain, and muscle weakness after surgery.

Parathyroidectomy May Improve SHPT Patient Survival

Parathyroidectomy May Improve SHPT Patient Survival

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ESRD patients with SHPT undergoing surgery had a 26% lower risk for all-cause mortality compared with medical management.

Elevated PTH Tied to Arteriovenous Fistula Maturation Failure

Elevated PTH Tied to Arteriovenous Fistula Maturation Failure

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Secondary hyperparathyroidism may have a detrimental effect on successful arteriovenous fistula creation, researcher says.

Etelcalcetide Injection Into Parathyroid Glands Safe

Etelcalcetide Injection Into Parathyroid Glands Safe

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In a pilot study, investigators observed no harmful effects from etelcalcetide injection, and 5 of 10 of patients had a greater than 50% decline in PTH levels.

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

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Therapy with paricalcitol alone achieved the greatest decline in intact parathyroid hormone among hemodialysis with secondary hyperparathyroidism.

Biomarkers Predict Renal Function Decline, CV Events

Biomarkers Predict Renal Function Decline, CV Events

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High levels of parathyroid hormone and fibroblast growth factor 23 in CKD patients are associated with need for renal replacement therapy or a 50% or greater decline in eGFR.

No iPTH Oversuppression With Extended-Release Calcifediol

No iPTH Oversuppression With Extended-Release Calcifediol

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Intact parathyroid hormone levels decline in proportion with SHPT severity in patients taking the drug.

Vitamin D Supplementation Improves PTH, Bone Turnover in CKD

Vitamin D Supplementation Improves PTH, Bone Turnover in CKD

Cholecalciferol can also correct vitamin D deficiency in patients with chronic kidney disease.

Low Protein Diet With Keto Analogues May Prevent SHPT

Low Protein Diet With Keto Analogues May Prevent SHPT

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Dialysis patients treated with a low protein diet with keto analogues had lower levels of parathyroid hormone than those on a normal diet, meta-analysis shows.

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

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By the third month of treatment, 59% of etelcalcetide recipients had reached target iPTH levels of 60 to 240 pg/mL compared with just 1.3% of placebo recipients.

CKD Patients Frequently Re-hospitalized After Parathyroidectomy

CKD Patients Frequently Re-hospitalized After Parathyroidectomy

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Parathyroidectomy for hyperparathyroidism in CKD patients is associated with a 30-day readmission rate of 17.2%.

Etelcalcetide Shows Efficacy, Safety Over 52 Weeks

Etelcalcetide Shows Efficacy, Safety Over 52 Weeks

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By 52 weeks, 87.5% of patients had reached an intact parathyroid hormone target range of 60 to 240 pg/mL.

Expert Panel: Calcifediol Possibly a Better Option for SHPT

Expert Panel: Calcifediol Possibly a Better Option for SHPT

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Calcifediol is possibly more effective at alleviating 25(OH)D deficiency and reducing parathyroid hormone compared with other nutritional vitamin D therapies.

Total Parathyroidectomy Procedures Similarly Efficacious

Total Parathyroidectomy Procedures Similarly Efficacious

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Surgical complications and symptom improvement, for example, did not differ significantly between total parathyroidectomy with and without autotransplantation.

Low Vitamin D, High PTH Up Mortality Risk in Early CKD

Low Vitamin D, High PTH Up Mortality Risk in Early CKD

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The risk for premature death increased by 62% and 42% for stage 3 CKD patients with vitamin D deficiency and elevated parathyroid hormone levels, respectively.

Parathyroidectomy Associated With Morbidity, Mortality

Parathyroidectomy Associated With Morbidity, Mortality

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Single-center study reveals a hospitalization rate of 14% following total parathyroidectomy without autotransplantation.

Efficacy of Paricalcitol vs Other VDRAs Unclear

Efficacy of Paricalcitol vs Other VDRAs Unclear

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Meta-analysis shows comparable efficacy in lowering iPTH, but analyses of patient-centered outcomes such as mortality and cardiovascular death were not possible.

Researchers: Iron-based Binders Best for Hyperphosphatemia

Researchers: Iron-based Binders Best for Hyperphosphatemia

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Of 7 phosphate binders, iron-based agents were optimal when efficacy and safety are considered.

Most Patients Prefer Medication to Surgery for SHPT

Most Patients Prefer Medication to Surgery for SHPT

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New survey shows that out-of-pocket costs are a major concern.

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

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Bone mineral density in the lumbar spine and femoral neck increased over time in hemodialysis patients who underwent total parathyroidectomy without autotransplantation.

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

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SHPT in those aged 65 years or older is associated with lower eGFR, low levels of 25-hydroxyvitamin D, and use of furosemide.

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

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