Secondary Hyperparathyroidism

Most Patients Prefer Medication to Surgery for SHPT

Most Patients Prefer Medication to Surgery for SHPT

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New survey shows that out-of-pocket costs are a major concern.

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

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Bone mineral density in the lumbar spine and femoral neck increased over time in hemodialysis patients who underwent total parathyroidectomy without autotransplantation.

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

Secondary Hyperparathyroidism Risk Higher in Elderly CKD Patients

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SHPT in those aged 65 years or older is associated with lower eGFR, low levels of 25-hydroxyvitamin D, and use of furosemide.

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

Parathyroidectomy Tied With Complications in Secondary, Tertiary Hyperparathyroidism

After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

Adynamic Bone Disease Prevalent in Type 2 Diabetes Patients With CKD

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Almost 40% of pre-dialysis patients with stage 4-5 CKD patients and type 2 diabetes had lab results suggesting low turnover bone disease.

High Post-op iPTH Linked With Increased Mortality in SHPT

High Post-op iPTH Linked With Increased Mortality in SHPT

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The risk of death more than tripled with iPTH levels above 600 pg/mL at 1 week after surgery.

Total PTx Without Autotransplantation May Improve Outcomes

Total PTx Without Autotransplantation May Improve Outcomes

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Meta-analysis reveals a lower risk of recurrence and persistence of SHPT when total parathyoidectomy is performed without transplanting parathyroid tissue.

Guidelines for CKD Mineral and Bone Disorder Updated

Guidelines for CKD Mineral and Bone Disorder Updated

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Among other changes, the new KDIGO guidelines highlight the potential dangers of hypercalcemia.

Hip Fracture Rates Falling Among ESRD Patients

Hip Fracture Rates Falling Among ESRD Patients

From 2003 to 2011 there was a 26.7% decrease in in-hospital mortality rate after hip fracture.

Review Supports Sodium Thiosulfate Use for Calciphylaxis

Review Supports Sodium Thiosulfate Use for Calciphylaxis

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Patients often received sodium thiosulfate with other therapies.

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

Novel Parathyroidectomy Procedure May Result in Durably Low PTH

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Typically, about 2% to 20% of SHPT patients experience recurrence or persistence after conventional parathyroidectomy procedures, likely due to residual parathyroid tissue.

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

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In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.

Cardiothoracic Ratio Predicts Mortality in SHPT Patients

Cardiothoracic Ratio Predicts Mortality in SHPT Patients

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Higher CTR was associated with greater risks of death from cardiovascular disease and other causes.

Cinacalcet May Lower Death Risk in Dialysis Subgroups

Cinacalcet May Lower Death Risk in Dialysis Subgroups

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Researchers found lower all-cause mortality for cinacalcet-treated patients concomitantly treated with vitamin D and phosphate binders, for example.

Surgery More Effective for Post-Transplant Hyperparathyroidism

Surgery More Effective for Post-Transplant Hyperparathyroidism

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Up to half of transplant patients might experience tertiary hyperparathyroidism.

Residual Kidney Function Predicts Mortality in CKD-MBD

Residual Kidney Function Predicts Mortality in CKD-MBD

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In a study of hemodialysis patients, mortality risk increased along with phosphorus level, particularly among patients with higher residual renal urea clearance.

High-Volume Surgeons Improve Parathyroidectomy Outcomes

High-Volume Surgeons Improve Parathyroidectomy Outcomes

The researchers found that patients of high-volume surgeons had a lower rate of vocal cord paralysis compared to patients of low-volume surgeons.

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

Initial Low-Dose Etelcalcetide Feasible for SHPT Patients

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At 18 months, PTH levels were within target for 67% and 68% of participants who initiated etelcalcetide at 2.5 mg and 5 mg, respectively.

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

Sucroferric Oxyhydroxide Ups Phosphorus Control in SHPT

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Nearly twice as many patients achieved the target phosphorus range after a year of taking the phosphate binder, regardless of iPTH level.

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

Cinacalcet Appears to Ease Hyperparathyroidism in Transplant Patients

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Cinacalcet treatment may serve as a bridge to parathyroidectomy or as an alternative, researchers say.

Eliminating Phosphorus Food Additives Does Not Compromise Nutrition

Eliminating Phosphorus Food Additives Does Not Compromise Nutrition

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Replacing foods containing phosphorus-based additives with similar foods not containing these additives can control hyperphospatemia without interfering with nutritional status.

Post-Parathyroidectomy Bone Changes in HD Patients Characterized

Post-Parathyroidectomy Bone Changes in HD Patients Characterized

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Researchers using spectral computed tomography found that calcium concentration increased in cortical bone and decreased in cancellous bone.

Study Finds New Clues to CKD Mineral Bone Disease

Study Finds New Clues to CKD Mineral Bone Disease

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Bone expression of sclerostin and parathyroid hormone receptor-1 increased in earlier stages of CKD, whereas FGF-23 and phosphorylated b-catenin showed increased expression in later stages.

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

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Alkaline phosphatase was more strongly linked to mortality compared with other biomarkers of chronic kidney disease-mineral and bone disorder.

PTH-Suppressive Vitamin D Dose in Obese Patients ID'd

PTH-Suppressive Vitamin D Dose in Obese Patients ID'd

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Study suggests the lowest dose of vitamin D3 supplements needed to suppress parathyroid hormone in overweight and obese adults is 1000 IU daily.

Initial Low-Dose Cinacalcet Feasible for SHPT Patients

Initial Low-Dose Cinacalcet Feasible for SHPT Patients

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In a study, similar proportions of patients taking a low dose and standard dose of cinacalcet had a greater than 30% reduction in iPTH levels at 16 weeks.

How 'Bundling' Changed Dialysis Care

How 'Bundling' Changed Dialysis Care

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Decreased use of erythropoiesis-stimulating agents and an uptick in peritoneal dialysis use are among the trends.

Vitamin D Status Linked to Body Fat in Older Women

Vitamin D Status Linked to Body Fat in Older Women

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Adipose tissue may be more important than vitamin D intake, new study suggests.

A Case of SHPT Affecting the Skeleton

A Case of SHPT Affecting the Skeleton

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Clinicians should be aware of these uncommon radiograph findings.

Novel Calcimimetic Approved for Secondary Hyperparathyroidism

Novel Calcimimetic Approved for Secondary Hyperparathyroidism

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Etelcalcetide is the first new approved treatment for the condition in 12 years.

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