Researchers Link Elevated PTH to High Uric Acid

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This article is part of our ongoing coverage of Renal Week 2009. Click here for a complete list of our Renal Week Live articles.


Key Points

  • Elevated serum parathyroid hormone (PTH) levels are associated with higher serum uric acid levels in the U.S. adult population.
  • For every log increase in PTH, serum uric acid increased by 0.77 mg/dL.

Elevated serum parathyroid hormone (PTH) levels are associated with higher serum uric acid levels in the U.S. adult population, investigators reported at ASN's Renal Week 2009.

Diana I. Jalal, MD, of the University of Colorado Hospital in Aurora, and colleagues examined the association between PTH concentrations and uric acid levels in 9,766 adult participants in the National Health and Nutrition Examination Survey (NHANES), which looked at a representative sample of the adult U.S. population.

Of these subjects, 1,409 (14%) had elevated PTH levels (65 pg/mL or higher), 4,199 (43%) had serum uric acid levels of 5.5 mg/dL or higher, and 1,172 (12%) had serum uric acid levels of 7 mg/dL or higher.

Subjects with high PTH levels were older and more likely to be male and to have diabetes, the study revealed.

After adjusting for age, gender, race, hypertension, BMI, diabetes, calcium, phosphorus, alkaline phosphatase, 25-hydroxyvitamin D levels, and estimated glomerular filtration rate, PTH levels predicted higher serum uric acid levels. For every log increase in PTH, serum uric acid increased by 0.77 mg/dL.

Compared with a PTH level below 65 pg/mL, a PTH level of 65 pg/mL or higher was associated with a 0.3 mg/dL increase in serum uric acid. These results were unchanged in the absence of significant kidney disease.

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