Cinacalcet Effective for Refractory Hyperparathyroidism

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This article is part of our ongoing coverage of Renal Week 2009. Click here for a complete list of our Renal Week Live articles.


Key Points

  • Cinacalcet showed long-term efficacy in reducing serum parathyroid hormone (PTH) and calcium levels in renal transplant patients with refractory tertiary hyperparathyroidism.
  • Serum PTH decreased significantly from a mean of 236 pmol/L at baseline to 180 at 12 months.
  • Serum calcium decreased significantly from 10.8 mg/day to 10.0.

Cinacalcet showed long-term efficacy in reducing serum parathyroid hormone (PTH) and calcium levels in renal transplant patients with refractory tertiary hyperparathyroidism, according to a study presented at ASN's Renal Week 2009.

Dimitrios-Anestis Moutzouris, MD, and colleagues at Evangelismos General Hospital in Athens, Greece, followed 24 renal transplant recipients (17 male, 7 female) who had stable renal function at least three months before administration of cinacalcet. Seventeen patients were on cyclosporine, five were on tacrolimus, and two were on everolimus. The patients had a mean age of 56 years.

Clinicians started patients on cinacalcet a mean 27 months after transplantation because of hypercalcemia and hyperparathyroidism that was refractory to standard medical treatment (mainly vitamin D analogues). The usual dose of cinacalcet was 30-60 mg per day.

Serum PTH decreased significantly from a mean of 236 pmol/L at baseline to 180 at 12 months. During that same period, serum calcium decreased significantly from 10.8 mg/day to 10.0, the investigators reported. Renal function and serum phosphorus levels at 12 months were not significantly different from baseline.

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