Renal Dysfunction After Radical Nephrectomy Raises Cardiovascular Risks
PARIS—Renal dysfunction following radical nephrectomy (RN) for renal cancer is associated with an increased risk of cardiovascular (CV) events and non-cancer-related mortality, Japanese researchers reported at the 27th Annual Congress of the European Association of Urology.
Investigators at Tokyo Medical and Dental University Graduate School and Saitama Red Cross Hospital in Saitama reviewed data from 173 patients who underwent RN between 1980 and 2009. They defined renal dysfunction as an estimated glomerular filtration rate (eGFR) of less than 45 mL/min/1.73 m2.
During a median follow-up of 71 months, CV events occurred in 22 patients and 32 patients died. The five-year CV-event-free survival rates were 84.9%, 98.2%, and 96.1% for patients with a post-operative eGFR (in mL/min/1.73 m2) of less than 45, 45-59.9, and 60 or higher, respectively. The five-year non-cancer mortality rates were 10%, 2.7%, and 1.2%, respectively.
After adjusting for preoperative characteristics, post-operative renal dysfunction was associated with a three times increased risk of CV events and a 9.7 times increased risk of non-cancer mortality.