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Renal Cell Carcinoma

Data Suggest Caution in the Use of Nonsurgical Management of Renal Tumors

Jody A. Charnow May 22, 2012

New findings suggest a need to proceed with caution when deciding whether to use nonsurgical management (NSM) for patients with renal cell carcinoma, according to a report presented at the American Urological Association 2012 annual meeting.

Findings May Improve Mortality Predictions for RCC Patients

Jody A. Charnow May 20, 2012

New findings may better enable clinicians to predict cancer-specific and other-cause mortality among patients who have undergone nephrectomy for renal cell carcinoma (RCC), according to a report presented at the American Urological Association 2012 annual meeting.

Preoperative Imaging May Avert Unnecessary Adrenalectomy

Stephan Cho May 20, 2012

Preoperative cross-sectional imaging can prevent unnecessary adrenalectomy in patients undergoing radical nephrectomy for renal cell carcinoma (RCC), according to findings presented at the American Urological Association 2012 annual meeting.

Study Identifies RCC Risk Factors

Stephan Cho May 19, 2012

A history of kidney disease, hypertension, high body mass index (BMI), and smoking are independently associated with an increased risk of renal cell carcinoma (RCC), researchers reported at the American Urological Association 2012 annual meeting.

RCC Subtype Is Associated With Low Recurrence Rate

Jody A. Charnow April 29, 2012

Patients with papillary renal cell carcinoma (pRCC) have a low risk of tumor recurrence and cancer-related death after surgery.

Sickle Cell Trait and Medullary Renal Carcinoma

Surafel Gebreselassie, MD, Matthew N. Simmons, MD April 01, 2012

Since the discovery of Hemoglobin S (HbS), it has been known that the abnormal polymerization of deoxy-HbS is the main cause for vaso-occlusive crisis involving many organs including the kidneys in sickle cell disease (SCD).

Targeted Therapies Have Improved Survival Among Patients with Metastatic RCC

John Schieszer March 29, 2012

Overall survival appears to be improving significantly in patients with metastatic renal cell carcinoma (RCC).

RFA Successfully Treats Small Benign Renal Tumors

Jody A. Charnow March 08, 2012

Radiofrequency ablation (RFA) can effectively treat small benign tumors in a single session, and long-term outcomes of RFA for renal tumors depend on tumor size, according to the findings of two studies.

Hemodialysis Patients Not More Likely to Die from Renal Cell Carcinoma

Jody A. Charnow February 27, 2012

PARIS—Hemodialysis (HD) patients are no more likely to die from renal cell carcinoma (RCC) than patients with normal renal function, but they have decreased overall survival, Japanese investigators reported at the 27th Annual Congress of the European Association of Urology.

Immunotherapy May Improve mRCC Outcomes

John Schieszer February 08, 2012

SAN FRANCISCO—An immunotherapy (AGS-003) in combination with sunitinib may help prolong the lives of men with unfavorable risk, metastatic renal cell carcinoma (mRCC), according to new data from an open-label phase 2 study.

Bisphosphonates May Improve Outcomes in Patients with RCC and Bone Metastases

John Schieszer February 08, 2012

SAN FRANCISCO—Combining a bisphosphonate with sunitinib may improve progression-free survival (PFS) and overall survival (OS) in patients with bone metastases from renal cell carcinoma (RCC), that are treated with sunitinib, according to a multicenter, retrospective study presented at the 2012 Genitourinary Cancer Symposium.

Prior Sunitinib Duration Affects Second-Line RCC Therapy Outcomes

John Schieszer February 07, 2012

SAN FRANCISCO—Prior sunitinib treatment for nine months or longer may be associated with a longer progression-free survival (PFS) in patients with metastatic renal cell carcinoma (RCC) receiving axitinib as second-line treatment, according to a new study presented at the 2012 Genitourinary Cancer Symposium.

Kidney Cancer Tumor Size, Preoperative eGFR Linked

Jody A. Charnow January 30, 2012

Tumor diameter and decreased preoperative estimated glomerular filtration rate (eGFR) are independently correlated in patients undergoing surgery for renal cell carcinoma (RCC), researchers concluded.

Kidney Cancer Tied to Red Meat Intake

Jody A. Charnow January 27, 2012

Greater intake of red meat may increase the risk of renal cell carcinoma (RCC).

Radiofrequency Ablation, Partial Nephrectomy for RCC Offer Similar Long-Term Outcomes

Jody A. Charnow January 11, 2012

In appropriately selected patients, radiofrequency ablation (RFA) is an effective minimally invasive treatment for cT1a renal cell carcinoma (RCC) that offers long-term oncologic outcomes comparable to nephron-sparing surgery, data show.

Increased Lead Exposure May Raise Kidney Cancer Risk

Jody A. Charnow January 02, 2012

Higher blood lead levels are associated with an elevated risk of renal cell carcinoma (RCC), according to a study.

Panel Backs Axitinib for Advanced Kidney Cancer

Stephan Cho December 08, 2011

The FDA's Oncologic Drugs Advisory Committee, in a unanimous vote, agreed that data for the investigational drug axitinib (Pfizer) support a favorable benefit/risk profile for treating patients with advanced renal cell carcinoma (RCC) following failure of first-line systemic therapy.

Non-Cancer Death Less Likely with Partial Nephrectomy

Jody A. Charnow December 08, 2011

Patients who undergo partial nephrectomy (PN) for localized renal cell carcinoma (RCC) are more likely to die from causes other than their cancer compared with patients treated with radical nephrectomy (RN), data show.

Survival Better with Incidentally Detected RCC

Jody A. Charnow November 24, 2011

Incidental detection of renal cell carcinoma (RCC) is increasing and is associated with better survival from the malignancy, according to a population-based study conducted in Iceland.

Sunitinib's Safety, Efficacy Confirmed

Jody A. Charnow October 11, 2011

Expanded access trial shows poorer-risk patients can benefit from the drug for advanced kidney cancer.

SBRT Offers More Durable Pain Relief in Advanced RCC Patients

John Schieszer October 06, 2011

MIAMI BEACH, Fla.—Conventional radiotherapy (CRT) and stereotactic body radiotherapy (SBRT) provide relief of pain related to spine metastases in patients with advanced renal cell carcinoma (RCC), but CRT provides more rapid relief and SBRT has a more durable effect, according to new data presented at the American Society for Radiation Oncology annual meeting.

Study Links Renal Cancer, Multiple Myeloma

Jody A. Charnow September 22, 2011

Researchers have identified a bidirectional association between renal cell carcinoma (RCC) and multiple myeloma, which suggests that common risk factors influence development of both malignancies, according to a recent report in BJU International.

Kidney Cancer Linked to Nonaspirin NSAIDs

Jody A. Charnow September 14, 2011

Regular use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) may increase a person's risk of renal cell cancer (RCC), new findings suggest.

Early RCC Tumor Response to Sunitinib Bodes Well

Jody A. Charnow July 31, 2011

Early reduction in primary tumor (PT) size independently predicts better overall survival in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib, researchers reported.

Kidney Cancer vs. ESRD

Marc C. Smaldone, MD, Robert G. Uzzo, MD July 19, 2011

Incidentally detected renal tumors are increasingly diagnosed in patients with chronic kidney disease.

Kidney Cancer Vaccine Found to Prolong Survival

John Schieszer July 18, 2011

A new therapeutic vaccine may extend survival in patients with advanced renal cell carcinoma.

Drug for Advanced RCC Improves PFS

John Schieszer June 28, 2011

CHICAGO—An investigational drug called axitinib is more effective than sorafenib in prolonging progression-free survival (PFS) in patients previously treated for metastatic renal cell carcinoma (mRCC), according to data presented at the 47th Annual Meeting of the American Society of Clinical Oncology.

Reliable Biomarkers May Improve RCC Management

John Schieszer June 16, 2011

ORLANDO—Molecular features and information from gene and protein expression profiling of renal cell carcinoma (RCC) may increase the accuracy of current clinical prognostic models, a researcher said.

Smoking Found to Raise Risk for Advanced Kidney Cancer

Delicia Honen Yard June 16, 2011

Cigarette smoking is an independent risk factor for advanced renal cell carcinoma (RCC), according to researchers who studied 845 patients—including 207 (24.5%) with advanced disease—who underwent surgery for the cancer.