PSA Screening Lowers Prostate Cancer Mortality

Share this article:

PSA-based screening significantly decreases the risk of dying from prostate cancer (PCa), according to updated results of a large European study.

The European Randomized Study of Screening for Prostate Cancer involved 186,160 men aged 50 to 74 years at enrollment, with a predefined core age group of 162,388 men aged 55 to 69 years. Investigators randomly assigned subjects to a screening group or a control group. Men in the screening group were offered PSA-based screening and those in the control arm were not.

After a median follow-up of 11 years in the core age group, those in the screening arm had a 21% decreased risk of PCa death relative to controls, researchers reported in The New England Journal of Medicine (2012;366:981-990). The absolute reduction in mortality in the screening arm was 1.07 deaths per 1,000 men at a median follow-up of 11 years.

Additionally, the researchers calculated that to prevent one death from PCa at 11 years of follow-up, 1,055 men would need to be invited for screening and 37 cancers would need to be detected.

Overall mortality was similar between the two groups (18.2 deaths for 1,000 person-years in the screening arm and 18.5 deaths per 1,000 person-years in the control group).

The investigators stated that the controversy regarding PCa screening has been renewed by the publication of the draft report of the U.S. Preventive Services Task Force, which, after a literature-based analysis of the benefits and harms, recommended against PSA screening of asymptomatic men.

“Clearly, the issue can be resolved only on the basis of evidence that considers both the advantages and disadvantages of screening, data that are not available at this time,” the authors noted.

Share this article:
You must be a registered member of RUN to post a comment.

Next Article in Prostate Cancer

More in Prostate Cancer

Focal Prostate Cancer Therapy Safe, Feasible

Focal Prostate Cancer Therapy Safe, Feasible

In a study, none of the 62 men who had the treatment experienced erectile dysfunction or urinary incontinence.

MRI Highly Accurate in Detecting Significant Prostate Cancer

MRI Highly Accurate in Detecting Significant Prostate ...

Diffusion-weighted technique found to have a sensitivity and specificity of 89%-91% and 77%-81%, respectively.

BRCA2 Mutation Ups Prostate Cancer Death Risk

BRCA2 Mutation Ups Prostate Cancer Death Risk

In a study, the 12-year prostate cancer survival rate was 61.8% for men with the mutation versus 94.3% for those without it.