Prostate Cancer

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

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In a study, systematic biopsy detected clinically significant prostate cancer in only 3% of men with negative findings on multiparametic MRI.

Adverse Effects of Treatment for Localized PCa Clarified

Adverse Effects of Treatment for Localized PCa Clarified

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Findings from 2 new studies could enable more informed patient counseling about choice of therapy.

Nerve-sparing RP May Not Raise Positive Margin Risk

Nerve-sparing RP May Not Raise Positive Margin Risk

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Researchers found no evidence of worse cancer outcomes with nerve-sparing surgery.

TRT Does Not Appear to Increase PCa Risk

TRT Does Not Appear to Increase PCa Risk

A population-based study showed no association between total prostate cancer risk and testosterone replacement therapy (TRT).

Bone Metastases Seldom Progress During Radium-223 Therapy

Bone Metastases Seldom Progress During Radium-223 Therapy

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At 6 months of treatment, bone imaging showed stable disease in 94% of patients with available data, study finds.

Prostate MRI Quality May Improve With Bowel Prep

Prostate MRI Quality May Improve With Bowel Prep

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In multiparametric magnetic resonance imaging, rectal distension have a negative effect on T2-weighted and diffusion-weighted images.

Targeted Biopsy Detects Gleason Score Upgrading in AS

Targeted Biopsy Detects Gleason Score Upgrading in AS

Men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading than men with an initial Gleason score of 3 + 3 at 3 years.

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

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Clinical or radiologic progression is less likely with abiraterone plus prednisone than cabazitaxel following first-line docetaxel, study finds.

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

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Study finds that PSA and PSAD indicated prostate cancer above Gleason score 6 for white men only.

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

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In a retrospective study, patients lived the longest if they received docetaxel followed by cabazitaxel and then abiraterone or enzalutamide.

Urologists Support Targeted Biopsy

Urologists Support Targeted Biopsy

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In a survey, 3 in 5 urologists in the United States indicated they perform MRI-US guided biopsy in current practice.

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

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From 1995 to 2011, prostate cancer deaths fell by 13.0% among Danish patients diagnosed with low-risk disease.

Prostate Cancer Treatment Prolongs Survival

Prostate Cancer Treatment Prolongs Survival

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Study compared PCa patients who underwent surgery or radiation treatment with a matched group of non-cancer controls.

Black Patients May Be Adversely Affected by Less PSA Screening

Black Patients May Be Adversely Affected by Less PSA Screening

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Black patients who met age criteria for PSA screening were 28% more likely to die of their prostate cancer than patients ineligible for screening.

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

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In a study, each 1-unit increment in body mass index was associated with a 16% lower mortality risk.

Metastatic Prostate Cancer Death Rates Declining

Metastatic Prostate Cancer Death Rates Declining

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Cancer-specific mortality rates dropped from 72.8% in 1995 to 55.8% in 2011, according to a Danish study.

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

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Researchers compared targeted prostate biopsy based on biparametric magnetic resonance imaging with standard 12-core systematic biopsy.

Cancer Mortality Rate Declining in the US

Cancer Mortality Rate Declining in the US

Cancer mortality decreased by 20.1% between 1980 and 2014, from 240.2 to 192.0 deaths per 100 000 population.

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

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Combined treatment for recurrent prostate cancer after radical prostatectomy results in decreased long-term all-cause and cancer-specific mortality.

Urologists' Use of Observation for PCa Raises Concern

Urologists' Use of Observation for PCa Raises Concern

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For individual urologists, the probability of using observation for low-risk disease ranged widely from 5.1% to 71.2%.

Targeted Biopsy Improves Detection of Significant PCa in Black Men

Targeted Biopsy Improves Detection of Significant PCa in Black Men

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Targeted biopsy should be considered for grade 4-5 lesions on the Likert scale, researchers say.

Anxiety, Depression May Up Death Risk for Prostate Cancer

Anxiety, Depression May Up Death Risk for Prostate Cancer

Higher death rates found in cancers not related to smoking, carcinoma of the colorectum, prostate, pancreas, oesophagus, and leukemia.

Antidiabetic Drug Use May Cut PCa Risk

Antidiabetic Drug Use May Cut PCa Risk

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The results suggest that hyperinsulinemia may be a risk factor for prostate cancer.

Asians With Metastatic Prostate Cancer Have Better Survival

Asians With Metastatic Prostate Cancer Have Better Survival

The median OS differed by race, with superior OS observed among Asian men than among men of other races.

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

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Using imaging to triage men with elevated PSA might avoid a quarter of unnecessary biopsies, according to a study.

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

No benefit of autologous urethral sling placement at robotic assisted radical prostatectomy on early return of continence at 6 months.

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

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Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Prostate Cancer Death Rate Fell in the United States

Prostate Cancer Death Rate Fell in the United States

The investigators found that the cancer mortality rate hit its peak in 1991, before beginning a steady slide of roughly 1.5% per year among both men and women through 2014.

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

The proportions of skeletal-related events did not differ significantly between the every 4-week dosing group vs the every 12-week dosing group of bone metastases patients.

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate Cancer Risk Lower in Men With Prostate Atrophy

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Prostate atrophy in more cores also was associated with lower risks of low- and high-grade disease.

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