Prostate Cancer

Metformin Plus Chemo Does Not Up mCRPC Survival

Metformin Plus Chemo Does Not Up mCRPC Survival

Survival curves showed that metformin use with docetaxel did not improve prostate cancer specific survival or overall survival.

USPSTF Issues Draft PCa Screening Recommendations

USPSTF Issues Draft PCa Screening Recommendations

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The US Preventive Services Task Force now suggests decisions about PSA testing should be made on an individual basis for men aged 55 to 69.

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

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Study identifies PSADT cut-points that can aid in risk stratification of men with non-metastatic castration-resistant prostate cancer.

Prostate Cancer Risk Lower in Black Men With High VDBP

Prostate Cancer Risk Lower in Black Men With High VDBP

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Highest vs lowest quartile of vitamin D binding protein associated with 55% lower odds of prostate cancer.

Prostate Cancer Progression Risk in AS Not Linked to Family History

Prostate Cancer Progression Risk in AS Not Linked to Family History

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A family history of prostate cancer was not a major determinant of disease progression during active surveillance, according to a systematic review.

Taking Aspirin Regularly May Reduce Death From Cancer

Taking Aspirin Regularly May Reduce Death From Cancer

Regular aspirin use linked to lower risk of cancer mortality, especially colorectal, breast, and prostate cancer.

Earlier vs Later Prostate Cancer Recurrence Characterized

Earlier vs Later Prostate Cancer Recurrence Characterized

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Pathologic Gleason scores, positive surgical margin rates, and PSA doubling times differentiate earlier from later biochemical recurrence after radical surgery.

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Among men under the age of 65, men who got 3 to 5 hours of sleep per night had a 55% greater risk of dying of prostate cancer than men who got 7 hours of sleep per night.

Predictors of Post-RARP Readmission Identified

Predictors of Post-RARP Readmission Identified

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Patients with longer hospital stays and pre-discharge complications were at increased risk of readmission within 30 days of discharge.

Many Men Lack Information on PSA Screening Pros, Cons

Many Men Lack Information on PSA Screening Pros, Cons

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In 2014, 33.9% of men reported that their health care providers failed to communicate the benefits and risks of PSA-based screening, an increase from 2012.

Study Supports PCa Screening With MRI vs TRUS-biopsy

Study Supports PCa Screening With MRI vs TRUS-biopsy

Population-based prostate cancer screening with MRI has a significantly better risk/benefit ratio.

Study Finds Low Rate of AS Failure Regardless of PCa Risk

Study Finds Low Rate of AS Failure Regardless of PCa Risk

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Select intermediate- and high-risk patients had no greater risks of metastases, AS failure, or interventions over a median of 4 years.

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

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Study finds no difference in metastasis-free survival observed after 15 years compared with radiation therapy or radical prostatectomy.

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

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In a study, systematic biopsy detected clinically significant prostate cancer in only 3% of men with negative findings on multiparametic MRI.

Adverse Effects of Treatment for Localized PCa Clarified

Adverse Effects of Treatment for Localized PCa Clarified

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Findings from 2 new studies could enable more informed patient counseling about choice of therapy.

Nerve-sparing RP May Not Raise Positive Margin Risk

Nerve-sparing RP May Not Raise Positive Margin Risk

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Researchers found no evidence of worse cancer outcomes with nerve-sparing surgery.

TRT Does Not Appear to Increase PCa Risk

TRT Does Not Appear to Increase PCa Risk

A population-based study showed no association between total prostate cancer risk and testosterone replacement therapy (TRT).

Bone Metastases Seldom Progress During Radium-223 Therapy

Bone Metastases Seldom Progress During Radium-223 Therapy

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At 6 months of treatment, bone imaging showed stable disease in 94% of patients with available data, study finds.

Prostate MRI Quality May Improve With Bowel Prep

Prostate MRI Quality May Improve With Bowel Prep

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In multiparametric magnetic resonance imaging, rectal distension have a negative effect on T2-weighted and diffusion-weighted images.

Targeted Biopsy Detects Gleason Score Upgrading in AS

Targeted Biopsy Detects Gleason Score Upgrading in AS

Men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading than men with an initial Gleason score of 3 + 3 at 3 years.

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

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Clinical or radiologic progression is less likely with abiraterone plus prednisone than cabazitaxel following first-line docetaxel, study finds.

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

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Study finds that PSA and PSAD indicated prostate cancer above Gleason score 6 for white men only.

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

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In a retrospective study, patients lived the longest if they received docetaxel followed by cabazitaxel and then abiraterone or enzalutamide.

Urologists Support Targeted Biopsy

Urologists Support Targeted Biopsy

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In a survey, 3 in 5 urologists in the United States indicated they perform MRI-US guided biopsy in current practice.

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

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From 1995 to 2011, prostate cancer deaths fell by 13.0% among Danish patients diagnosed with low-risk disease.

Prostate Cancer Treatment Prolongs Survival

Prostate Cancer Treatment Prolongs Survival

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Study compared PCa patients who underwent surgery or radiation treatment with a matched group of non-cancer controls.

Black Patients May Be Adversely Affected by Less PSA Screening

Black Patients May Be Adversely Affected by Less PSA Screening

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Black patients who met age criteria for PSA screening were 28% more likely to die of their prostate cancer than patients ineligible for screening.

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

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In a study, each 1-unit increment in body mass index was associated with a 16% lower mortality risk.

Metastatic Prostate Cancer Death Rates Declining

Metastatic Prostate Cancer Death Rates Declining

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Cancer-specific mortality rates dropped from 72.8% in 1995 to 55.8% in 2011, according to a Danish study.

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

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Researchers compared targeted prostate biopsy based on biparametric magnetic resonance imaging with standard 12-core systematic biopsy.

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