Prostate Cancer

PSA Testing in Controls of Screening Trial May Undermine Results

PSA Testing in Controls of Screening Trial May Undermine Results

Over 15 years of follow-up, considerable proportion of men undergo prostate-specific antigen testing

Novel Markers May Predict Prostate Cancer in Non-Black Men

Novel Markers May Predict Prostate Cancer in Non-Black Men

No added benefit was seen with the addition of biomarkers for African-American men.

Multimodal Therapy Found to Benefit Men With LN-positive PCa

Multimodal Therapy Found to Benefit Men With LN-positive PCa

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New findings suggest that clinicians consider the pathologic characteristics of the primary tumor as well as the burden of LN metastases when deciding on management, investigators say.

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

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Radiotherapy for prostate cancer patients with persistently elevated PSA after radical surgery improved survival only among those with worse pathologic characteristics.

Prostate Cancer Tests Are Fine With Patients Permission

Prostate Cancer Tests Are Fine With Patients Permission

Routine prostate cancer screenings can be done as long as the patient makes the decision after a physician consultation.

High-income US Counties Have Higher Diagnoses of PCa

High-income US Counties Have Higher Diagnoses of PCa

High-income counties had far higher diagnosis rates for the four cancers than low-income counties, but the combined mortality rate was similar for both.

Survival Up With Patient-Reported Symptom Monitoring During Chemo

Survival Up With Patient-Reported Symptom Monitoring During Chemo

The researchers found that the median overall survival was 31.2 and 26.0 months in the PRO and usual care groups, respectively.

The New mCRPC Drugs: Clinical Practice Trends and Directions

The New mCRPC Drugs: Clinical Practice Trends and Directions

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Renal & Urology News spoke with two researchers who have been involved in studies of these agents: E. David Crawford, MD, and Tomasz M. Beer, MD.

Men Need Better Understanding of PCa Genetic Test Results

Men Need Better Understanding of PCa Genetic Test Results

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Some men who undergo multigene testing for inherited prostate cancer misinterpret findings of variants of uncertain significance.

Surgery May Offer Better Survival for Younger Men With High-risk PCa

Surgery May Offer Better Survival for Younger Men With High-risk PCa

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Younger patients who chose surgery vs radiation for initial treatment had a 48% survival advantage.

Extended PLND Not Associated With Short-Term Oncologic Benefits

Extended PLND Not Associated With Short-Term Oncologic Benefits

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Extended pelvic lymph node dissection versus limited dissection during radical prostatectomy does not improve biochemical recurrence rates.

Chronic Prostatitis Has Adverse Effects on Sperm

Chronic Prostatitis Has Adverse Effects on Sperm

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CBP was associated with a reduction in sperm concentration, sperm vitality, sperm total and progressive motility.

Single Radiation Dose Can Ease Spinal Cord Compression

Single Radiation Dose Can Ease Spinal Cord Compression

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New findings establish single-dose radiotherapy as the standard of care for metastatic spinal canal compression, at least for patients with a short life expectancy, researcher says.

Survival Predictors ID'd in mCRPC Patients Treated With Sipuleucel-T

Survival Predictors ID'd in mCRPC Patients Treated With Sipuleucel-T

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ECOG status and baseline PSA and PSADT are significantly associated with overall survival.

Low-PSA, High-Grade Prostate Cancer Especially Lethal

Low-PSA, High-Grade Prostate Cancer Especially Lethal

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Men with PSA values of 2.5 ng/mL or less and Gleason 8 to 10 prostate tumors are at higher risk of death than other high-risk PCa patients.

Costs Rise After Discovery of Prostate Cancer Metastases

Costs Rise After Discovery of Prostate Cancer Metastases

The researchers found that predicted monthly costs remained relatively stable throughout the observation period among the controls.

First-Line Abiraterone-ADT Combo for Hormone-Naïve PCa Ups Survival

First-Line Abiraterone-ADT Combo for Hormone-Naïve PCa Ups Survival

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Addition of abiraterone to androgen deprivation therapy for patients with hormone-naïve advanced prostate cancer may be a new standard of care.

Abiraterone Plus ADT Ups Prostate Cancer Patient Survival

Abiraterone Plus ADT Ups Prostate Cancer Patient Survival

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The 3-year overall survival rate among prostate cancer patients starting long-term hormone therapy was 83% vs 76% for men receiving abiraterone plus ADT vs ADT alone.

Diminished QOL Reported More Than 10 Years After PCa Treatment

Diminished QOL Reported More Than 10 Years After PCa Treatment

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Urinary incontinence and diminished sexual function were common after a median follow-up of nearly 15 years, study finds.

Salvage RARP Feasible After PCa Focal Therapy Failure

Salvage RARP Feasible After PCa Focal Therapy Failure

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Overall complication rates were similar between primary and salvage RARP groups, but there were some notable differences in prognosis.

MRI Accuracy for Prostate Cancer Challenged

MRI Accuracy for Prostate Cancer Challenged

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Systematic biopsies always should be performed in conjunction with targeted biopsy in men with suspected clinically significant PCa at mpMRI.

Novel PSA Assay Improves Prostate Cancer Diagnosis

Novel PSA Assay Improves Prostate Cancer Diagnosis

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The new test, IsoPSA, measures all PSA isoforms in serum and more accurately discriminates high-grade cancer from benign disease.

Combined Urinary Testing Helps Detect Aggressive PCa, Avoid Biopsy

Combined Urinary Testing Helps Detect Aggressive PCa, Avoid Biopsy

Combining testing of urinary T2:ERG, PCA3 at thresholds that detected aggressive prostate cancer improved specificity from 18% to 39%.

Detection Down for Prostate Cancer, Up for Other Cancers Since ACA

Detection Down for Prostate Cancer, Up for Other Cancers Since ACA

The investigators found that the percentage of patients diagnosed with stage I cancer increased significantly from 2013 to 2014 after the ACA was implemented.

Prostate Cancer Subtypes Differ in ADT Response After Surgery

Prostate Cancer Subtypes Differ in ADT Response After Surgery

Only luminal B prostate cancers were significantly associated with postoperative response to ADT in a subset analysis in retrospective cohorts.

PCa Active Surveillance Safe, Effective for Younger Patients

PCa Active Surveillance Safe, Effective for Younger Patients

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A majority of active surveillance patients under age 60 did not progress to definitive prostate cancer treatment.

MRI-Fusion Biopsy Benefits PCa Active Surveillance Patients

MRI-Fusion Biopsy Benefits PCa Active Surveillance Patients

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Targeting PI-RADS 4 and 5 lesions for confirmatory biopsy improves detection of clinically significant cancer.

Sipuleucel-T Survival Benefit Greater in Blacks

Sipuleucel-T Survival Benefit Greater in Blacks

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Median overall survival was 9.3 months longer for black versus white patients with metastatic castration-resistant prostate cancer.

Fusion Biopsy Ups Detection of Clinically Significant PCa

Fusion Biopsy Ups Detection of Clinically Significant PCa

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Fusion biopsy has improved over the last decade and increasingly detects clinically significant prostate cancer, according to data trends from one institution.

Prostate Cancer Distant Metastasis Predicted by APV

Prostate Cancer Distant Metastasis Predicted by APV

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Highest quartile of alkaline phosphatase velocity in men who experience biochemical recurrence after radical prostatectomy is associated with 2-fold higher risk.

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