Prostate Cancer

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

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Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Prostate Cancer Death Rate Fell in the United States

Prostate Cancer Death Rate Fell in the United States

The investigators found that the cancer mortality rate hit its peak in 1991, before beginning a steady slide of roughly 1.5% per year among both men and women through 2014.

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

The proportions of skeletal-related events did not differ significantly between the every 4-week dosing group vs the every 12-week dosing group of bone metastases patients.

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate Cancer Risk Lower in Men With Prostate Atrophy

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Prostate atrophy in more cores also was associated with lower risks of low- and high-grade disease.

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

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In a study, 53.1% of patients had concomitant prostate cancer in radical cystectomy specimens.

New Prostate Cancer Grading System Validated

New Prostate Cancer Grading System Validated

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Proposed 5-tiered system found to predict the risk of prostate cancer-specific mortality.

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Patients on active surveillance with stable disease at the time of initial surveillance prostate biopsy may be appropriate candidates for less intensive surveillance prostate biopsy schedules.

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

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Mutation carrier status was associated with earlier death and among lethal prostate cancer patients (age 67 vs 72 in non-carriers) and shorter survival.

Prostate Cancer AS Patients May Benefit from MRI/Fusion Biopsy

Prostate Cancer AS Patients May Benefit from MRI/Fusion Biopsy

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In patients undergoing confirmatory biopsy for active surveillance, MRI can increase detection of clinically significant tumors compared with standard systematic biopsy.

<i>PITX2</i> Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 methylation was increased in tumor-positive biopsies.

Prostate Cancer Active Surveillance Criteria May Need Updating

Prostate Cancer Active Surveillance Criteria May Need Updating

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When MRI-US fusion biopsy is added to the standard 12-core biopsy, the number of men eligible for active surveillance decreases, study finds.

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

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Magnetic resonance imaging of the prostate missed 13% of high-grade cancers that were later found on transrectal ultrasound-guided biopsy.

Radium-223 Reduces Hospital Usage for Skeletal Events

Radium-223 Reduces Hospital Usage for Skeletal Events

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CRPC patients treated with radium-223 spent fewer days in the hospital both before and after a skeletal event compared with placebo recipients.

Aggressive Prostate Cancer Diagnoses Declining in US

Aggressive Prostate Cancer Diagnoses Declining in US

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Study of men diagnosed with PCa from 2008 to 2013 found declining incidence among whites, blacks, Hispanics, and Asian/Pacific Islanders.

New Prostate Cancer Grading System Predicts Survival After RP

New Prostate Cancer Grading System Predicts Survival After RP

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Study shows a significant difference in all-cause and cancer-specific mortality between Gleason score 8 and Gleason score 9-10 disease.

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Complication Risk Due to Obesity Greater With Minimal Invasive RP

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Obesity predicts a wider range of complications in PCa patients who undergo laparoscopic or robot-assisted versus open radical prostatectomy.

CTCs May Aid Prostate Cancer Risk Stratification

CTCs May Aid Prostate Cancer Risk Stratification

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Analysis of circulating tumor cells may help identify patients at higher risk of biochemical recurrence after treatment.

PCa Cryoablation Achieves Acceptable Outcomes

PCa Cryoablation Achieves Acceptable Outcomes

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In a study, the 5-year estimated biochemical failure-free survival rate, based on the Phoenix definition, was 84%.

Infections After Prostate Biopsy Continue to Rise

Infections After Prostate Biopsy Continue to Rise

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Patients are at higher risk with the transrectal rather than transperineal approach.

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

The researchers observed no significant changes in intervention outcomes or in engagement with mindfulness for men with PC.

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

No increased risk of dementia for androgen deprivation therapy use versus nonuse.

Prostate Cancer Incidence Lower in HIV-Infected Men

Prostate Cancer Incidence Lower in HIV-Infected Men

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HIV-infected men and women had lower incidences of colorectal and lung cancer compared with the general population.

Cancer Patients Benefit From Exercise During, After Treatment

Cancer Patients Benefit From Exercise During, After Treatment

At the end of 3 months, the exercise and diet group was walking 3 to 4 times more quickly in a timed walk test of about a quarter-mile than the usual care group.

Study: 5-ARIs Do Not Increase PCa Death Risk

Study: 5-ARIs Do Not Increase PCa Death Risk

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New findings confirm previous reports.

Guidelines Developed for Prostate MRI After Negative Biopsy

Guidelines Developed for Prostate MRI After Negative Biopsy

High-quality prostate MRI should be strongly considered for any patient with a prior negative biopsy who is under evaluation for a repeat biopsy.

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

Second Opinions Rarely Alter PCa Treatment Decisions

Second Opinions Rarely Alter PCa Treatment Decisions

Obtaining second opinions was not associated with changes in treatment choice or with improvements in how patients viewed their quality of cancer care.

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Following the 2012 USPSTF recommendation against PSA screening in populations, rates of radical prostatectomy and biopsy have become significantly less common.

Biases Suspected in Prostate Cancer Risk Estimates

Biases Suspected in Prostate Cancer Risk Estimates

Incident prostate cancer cohorts were defined by examining men who were regularly screened from the placebo arms of two large prostate cancer prevention trials.

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