Prostate Cancer

FDA Approves Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer

FDA Approves Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer

This latest approval now makes enzalutamide the only FDA-approved oral medication indicated for both metastatic and nonmetastatic castration-resistant prostate cancer.

Prostate Cancer ADT Ups Thromboembolic Event Risk

Prostate Cancer ADT Ups Thromboembolic Event Risk

By

Pulmonary embolism is associated with GnRH agonist use and orchiectomy.

Partial Brachytherapy May Lead to Poor Outcomes in Intermediate-Risk PCa

Partial Brachytherapy May Lead to Poor Outcomes in Intermediate-Risk PCa

The impact of partial brachytherapy on metastasis and disease-specific mortality is unclear.

Advanced Prostate Cancer Variant More Common Than Thought

Advanced Prostate Cancer Variant More Common Than Thought

Incidence of tx-emergent small-cell neuroendocrine prostate cancer 17% among those with mCRPC.

Focal HIFU Effective Over 5 Years for PCa

Focal HIFU Effective Over 5 Years for PCa

By

Failure-free survival was 88% at 5 years among patients with nonmetastatic prostate cancer who underwent focal therapy with high-intensity focused ultrasound.

Automated Bone Scan Index Prognostic for Prostate Cancer

Automated Bone Scan Index Prognostic for Prostate Cancer

aBSI validated as prognostic biomarker of survival in metastatic castration-resistant prostate cancer

Conservative Management Up for Low-Risk Prostate Cancer in Veterans

Conservative Management Up for Low-Risk Prostate Cancer in Veterans

More conservative management and active surveillance utilized at VA hospitals from 2005 to 2015.

Metformin Added to Prostate Cancer ADT Ups Survival

Metformin Added to Prostate Cancer ADT Ups Survival

By

Metformin plus androgen deprivation therapy is associated with a lower death risk vs ADT alone in men without diabetes, study of US veterans shows.

Enzalutamide Delays Metastasis in CRPC

Enzalutamide Delays Metastasis in CRPC

By

Men receiving enzalutamide plus ADT had a significant 71% lower risk for metastasis or death compared with men receiving placebo plus ADT.

Testosterone Levels May Be Determined in Childhood

Testosterone Levels May Be Determined in Childhood

By

Children who migrated to the UK from Bangladesh before puberty and Bangladeshis born in the UK had significantly higher levels of testosterone compared with life-long residents of Bangladesh.

Prostate Cancer Vaccine Found Not to Improve Survival

Prostate Cancer Vaccine Found Not to Improve Survival

By

In a phase 3 trial, Prostvac-V/F did not significantly prolong overall survival among men with asymptomatic or minimally symptomatic mCRPC.

PIVOT Study Results Challenged

PIVOT Study Results Challenged

By

Researchers question the generalizability of a major study showing no significant difference in cancer-specific and overall survival between surgery and observation for localized prostate cancer.

End-of-Life Prostate Cancer-Related Complications Characterized

End-of-Life Prostate Cancer-Related Complications Characterized

By

Men with advanced prostate cancer at diagnosis have an elevated risk of spinal cord compression, renal failure, and other cancer-related morbidities.

Prostate Biopsy Complications Deter Patients From Re-Biopsy

Prostate Biopsy Complications Deter Patients From Re-Biopsy

By

Study participants with acute urinary retention after TRUS-guided prostate biopsy were 4.5 times more likely to skip a recommended re-biopsy than men who had no initial biopsy-related complications.

 Long-Term Data Support Finasteride for PCa Prevention

Long-Term Data Support Finasteride for PCa Prevention

By

Clinicians can rest easier about recommending finasteride to more men, according to experts.

Prostate Cancer Treatment Side Effects Linked to Distress

Prostate Cancer Treatment Side Effects Linked to Distress

Those with worse emotional distress also report worse urinary, sexual, bowel functions.

Biparametric MRI Improves Detection of Significant PCa

Biparametric MRI Improves Detection of Significant PCa

By

If externally validated, bpMRI could be used to triage men for prostate biopsy.

Abiraterone for mCRPC May Benefit Blacks More Than Whites

Abiraterone for mCRPC May Benefit Blacks More Than Whites

By

Abiraterone plus prednisone was associated with significantly greater PSA progression-free survival among patients who are black compared with white patients.

Robotics Involved in Most Urologic Cancer Surgeries

Robotics Involved in Most Urologic Cancer Surgeries

By

In 2015, 69% of surgeries for prostate, bladder, and kidney cancer were performed with robotic assistance, a new meta-analysis shows.

Enzalutamide for Advanced Prostate Cancer Does Not Worsen HRQoL

Enzalutamide for Advanced Prostate Cancer Does Not Worsen HRQoL

By

Enzalutamide decreases the risk of clinically meaningful deterioration in HRQoL compared with placebo in men with non-metastatic CRPC, new study finds.

AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

"We are confident this guideline is fully aligned with the latest science on treatments for patients with non-metastatic and metastatic CRPC," said Michael Cookson, MD, member of the 2018 amendment panel.

PSA Level 3 Months After Radiation Tx May Predict Outcome

PSA Level 3 Months After Radiation Tx May Predict Outcome

Findings for men with intermediate- and high-risk prostate cancer.

Current Smokers at Risk for Worse Prostate Cancer Outcomes

Current Smokers at Risk for Worse Prostate Cancer Outcomes

By

In a meta-analysis, smokers had an 89% greater risk of dying from prostate cancer compared with nonsmokers.

FDA Approves Yonsa for Metastatic Castration-Resistant Prostate Cancer

FDA Approves Yonsa for Metastatic Castration-Resistant Prostate Cancer

The approval of Yonsa was based on 2 randomized, placebo-controlled, multicenter Phase 3 studies in patients with mCRPC.

From 2008 to 2014, Prostate Cancer Testing, Treatment Down

From 2008 to 2014, Prostate Cancer Testing, Treatment Down

Sharpest decrease seen in privately insured men after 2011.

Laser Focal Ablation of Prostate Cancer Improves Outcomes

Laser Focal Ablation of Prostate Cancer Improves Outcomes

By

Men with low-risk PCa who underwent partial gland ablation with vascular-targeted photodynamic therapy were less likely than those on AS to require radical treatment.

Node-Positive Prostate Cancer on the Rise

Node-Positive Prostate Cancer on the Rise

By

The percentage of prostate cancer patients with positive lymph nodes increased from 2.4% in 2010 to 4.7% in 2014.

BPH, Cancers Linked to Peyronie's Disease

BPH, Cancers Linked to Peyronie's Disease

By

Men with Peyronie's disease have elevated risks of benign prostatic hyperplasia, prostatitis, and testis and prostate cancer, new studies reveal.

Testosterone Therapy Safe Despite Prostate Cancer History

Testosterone Therapy Safe Despite Prostate Cancer History

By

Findings from the largest study to date examining the effect of TRT in prostate cancer patients build on previous evidence showing that the treatment does not affect disease progression risk.

Incontinence, Impotence Risk After RP Linked to Metabolic Syndrome

Incontinence, Impotence Risk After RP Linked to Metabolic Syndrome

By

At 1 year post-op, patients with MetS prior to prostate surgery had a significantly lower continence rate than those without MetS (75.4% vs 82.6%).

Sign Up for Free e-newsletters