Suicide Gene Therapy Plus Radiation Shows Promise in Prostate Cancer
Immunomodulatory in situ gene tx/IMRT with or without hormonal tx deemed feasible, safe.
(HealthDay News) -- A combination of immune-modulatory in situ gene therapy (GT) and intensity-modulated radiotherapy (IMRT) is highly effective in treating prostate cancer, according to a study published online in the Journal of Radiation Oncology.
The GT was comprised of intraprostatic injection of adenoviral vector containing herpes simplex thymidine kinase followed by valacyclovir. The study included just over 60 patients who were divided into 2 groups. One group, who had cancer cells confined to the prostate, received radiation treatment. The second group, who had more aggressive prostate cancer, received both radiation and hormone treatments. The first group received the experimental gene therapy twice, and the second group received it 3 times during a phase II clinical trial conducted between 1999 and 2003.
Two years after treatment, prostate biopsies were negative in 83% of the first group and 79% of the second group. After 5 years, there was no sign of cancer recurrence in 94% of the first group and 91% of the second group. Five-year survival rates were 97 and 94%, respectively.
"The combination of immunomodulatory in situ gene therapy and IMRT with or without hormonal therapy is feasible, safe, and effective in the treatment of prostate cancer," the authors conclude. "This approach with long term follow up appears to provide better clinical outcome over historical controls. A randomized trial of this strategy is currently ongoing."
- Teh BS, Ishiyama H, Mai WY, Thompson TC, and Butler EB. Long-term Outcome of a Phase II Trial Using Immunomodulatory in Situ Gene Therapy in Combination With Intensity-modulated Radiotherapy With or Without Hormonal Therapy in the Treatment of Prostate Cancer. Journal of Radiation Oncology. doi: 10.1007/s13566-015-0239-y.