Video Series: Current Topics in the Treatment of Advanced PCa

Targeted Agents

Philip Kantoff, MD, Andrew Armstrong, MD, William Oh, MD, and A. Oliver Sartor, MD, discuss advances in treatment of castration-resistant prostate cancer and metastatic castration-resistant prostate cancer, specifically newer hormonal therapies.

Latest Prostate Cancer Features

MRI/US Fusion Improves Prostate Cancer Detection

MRI/US Fusion Improves Prostate Cancer Detection

The approach can help identify suitable candidates for active surveillance, but false positives and cost effectiveness are concerns.

Latest Prostate Cancer News

Metformin Plus Chemo Does Not Up mCRPC Survival

Metformin Plus Chemo Does Not Up mCRPC Survival

Survival curves showed that metformin use with docetaxel did not improve prostate cancer specific survival or overall survival.

USPSTF Issues Draft PCa Screening Recommendations

USPSTF Issues Draft PCa Screening Recommendations

The US Preventive Services Task Force now suggests decisions about PSA testing should be made on an individual basis for men aged 55 to 69.

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

Study identifies PSADT cut-points that can aid in risk stratification of men with non-metastatic castration-resistant prostate cancer.

Prostate Cancer Risk Lower in Black Men With High VDBP

Prostate Cancer Risk Lower in Black Men With High VDBP

Highest vs lowest quartile of vitamin D binding protein associated with 55% lower odds of prostate cancer.

Prostate Cancer Progression Risk in AS Not Linked to Family History

Prostate Cancer Progression Risk in AS Not Linked to Family History

A family history of prostate cancer was not a major determinant of disease progression during active surveillance, according to a systematic review.

Taking Aspirin Regularly May Reduce Death From Cancer

Taking Aspirin Regularly May Reduce Death From Cancer

Regular aspirin use linked to lower risk of cancer mortality, especially colorectal, breast, and prostate cancer.

Earlier vs Later Prostate Cancer Recurrence Characterized

Earlier vs Later Prostate Cancer Recurrence Characterized

Pathologic Gleason scores, positive surgical margin rates, and PSA doubling times differentiate earlier from later biochemical recurrence after radical surgery.

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Among men under the age of 65, men who got 3 to 5 hours of sleep per night had a 55% greater risk of dying of prostate cancer than men who got 7 hours of sleep per night.

Predictors of Post-RARP Readmission Identified

Predictors of Post-RARP Readmission Identified

Patients with longer hospital stays and pre-discharge complications were at increased risk of readmission within 30 days of discharge.

Many Men Lack Information on PSA Screening Pros, Cons

Many Men Lack Information on PSA Screening Pros, Cons

In 2014, 33.9% of men reported that their health care providers failed to communicate the benefits and risks of PSA-based screening, an increase from 2012.

Study Supports PCa Screening With MRI vs TRUS-biopsy

Study Supports PCa Screening With MRI vs TRUS-biopsy

Population-based prostate cancer screening with MRI has a significantly better risk/benefit ratio.

Study Finds Low Rate of AS Failure Regardless of PCa Risk

Study Finds Low Rate of AS Failure Regardless of PCa Risk

Select intermediate- and high-risk patients had no greater risks of metastases, AS failure, or interventions over a median of 4 years.

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

Study finds no difference in metastasis-free survival observed after 15 years compared with radiation therapy or radical prostatectomy.

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

In a study, systematic biopsy detected clinically significant prostate cancer in only 3% of men with negative findings on multiparametic MRI.

Adverse Effects of Treatment for Localized PCa Clarified

Adverse Effects of Treatment for Localized PCa Clarified

Findings from 2 new studies could enable more informed patient counseling about choice of therapy.

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