Biopsy Timing in Active Surveillance Not Tied to PCa Reclassification

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But PSA density and body mass index are associated with prostate cancer reclassification.
But PSA density and body mass index are associated with prostate cancer reclassification.

(HealthDay News) — Timing of the first active surveillance biopsy is not associated with increased adverse reclassification of prostate cancer, according to a study published in The Journal of Urology.

Liam C. Macleod, MD, from the University of Washington in Seattle, and colleagues analyzed the Canary PASS (Prostate Cancer Active Surveillance Study) to determine biopsy timing influence on rates of prostate cancer adverse reclassification at the first active surveillance biopsy. An increase in Gleason sum and/or 34% or more of cores with prostate cancer were used to define reclassification.

The researchers found that 21.1% of 421 men experienced reclassification at the first active surveillance biopsy. Eleven months was the median time from prostate cancer diagnosis to first active surveillance biopsy. Reclassification rates were 24% at <8 months, 19% at 8 to 13 months, and 22% ≥13 months (p = 0.65). The odds ratio (OR) of reclassification at 8 to 13 months and ≥13 months was 0.88 (95% confidence interval, 0.5 to 1.6) and 0.95 (95% confidence interval, 0.5 to 1.9), respectively, versus men biopsied at <8 months. Increased odds of reclassification were seen with prostate-specific antigen density ≥0.15 (referent <0.15; OR, 1.9) and body mass index ≥35 kg/m² (referent <25 kg/m²; OR, 2.4) were associated with increased odds of reclassification.

"In low risk patients on active surveillance, it may be reasonable to perform the first active surveillance biopsy at a later time, reducing the overall cost and morbidity of active surveillance," the authors write.

Reference

1. Macleod LC, Ellis WJ, Newcomb LF, et al. Timing of Adverse Prostate Cancer Reclassification on First Surveillance Biopsy: Results from the Canary Prostate Cancer Active Surveillance Study. J Urol. DOI: http://dx.doi.org/10.1016/j.juro.2016.10.090

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