Oncological Outcomes Similar Despite Prostatectomy Timing

Oncological Outcomes Similar Despite Timing of Prostatectomy
Oncological Outcomes Similar Despite Timing of Prostatectomy

Outcomes are similar between men with histologically comparable prostate cancer (PCa) who receive a radical prostatectomy (RP) after a period of active surveillance (AS) and those with low-risk disease who undergo immediate prostatectomy, according to a study published in The Journal of Urology (2013;190:91-96).

Raj Satkunasivam, MD, of the University of Toronto, and colleagues identified patients on AS treated with RP. They compared 289 AS patients who were ultimately treated with RP to age- and PSA-matched men undergoing immediate RP after a diagnosis of low-risk disease who were candidates for AS (group 1). Patients on AS with progression to Gleason 7 disease were also compared with men treated who had similar de novo disease (group 2).

The RP-after-AS group had worse pathological outcomes compared to group 1, whereas group 2 and those patients undergoing RP after AS with progression to Gleason 7 disease had similar pathologic outcomes. Biochemical recurrence was low and comparable between the RP-after-AS group and group 1 (2.6% vs. 5.4% at a median of 3.5 years after RP. Both groups had comparable erectile function and continence.

"Radical prostatectomy after a period of active surveillance does not appear to result in adverse pathological outcomes compared to patients with a similar preoperative pathology," the authors concluded.

Loading links....
You must be a registered member of Renal and Urology News to post a comment.

Sign up for free e-Newsletters