Monitor Older Men on ADT for Diabetes and CVD

This article originally appeared here.
Share this content:
Factors Associated with Depression in BPH Patients
Factors Associated with Depression in BPH Patients

(HealthDay News) -- For men diagnosed with prostate cancer aged older than 70 years, prolonged androgen deprivation therapy is associated with increased risk of diabetes and cardiovascular disease, especially among those with comorbidities, according to a study published in the April issue of The Journal of Urology.

Alicia K. Morgans, M.D., from Vanderbilt University and Geriatric Research, Education, and Clinical Center in Nashville, Tenn., and colleagues examined the correlation of androgen deprivation therapy exposure (2 years or less, more than 2 years, or none) with incident diabetes and cardiovascular disease in men with nonmetastatic prostate cancer. The cohort included 3,526 eligible participants, of whom 2,985 were without diabetes and 3,112 were without cardiovascular disease.

The researchers found that in men diagnosed with prostate cancer before age 70 years, androgen deprivation therapy was not associated with an elevated risk of diabetes or cardiovascular disease. In older men, prolonged androgen deprivation therapy and increasing age at diagnosis correlated with an increased risk of diabetes (at age 76 years: odds ratio, 2.1) and cardiovascular disease (at age 74 years: odds ratio, 1.9). Compared to men without comorbidities, those with comorbidities had greater risk of diabetes (odds ratio, 4.3) and cardiovascular disease (odds ratio, 8.1).

"Older men who receive prolonged androgen deprivation therapy should be closely monitored for diabetes and cardiovascular disease," the authors write.

Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.


  1. Morgans, AK, et al. The Journal of Urology, April 2015; doi:
You must be a registered member of Renal and Urology News to post a comment.

Sign up for free e-Newsletters