Obesity Tied to Risk of Prostate Cancer After Negative Biopsy

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Obesity Tied to Risk of Prostate Cancer After Negative Biopsy
Obesity Tied to Risk of Prostate Cancer After Negative Biopsy

In men with an initial benign biopsy or transurethral resection of the prostate, obesity at the time of the procedure is associated with the presence of precancerous lesions in the initial biopsy and a higher risk of developing prostate cancer (PCa), according to a study published online ahead of print in Cancer Epidemiology, Biomarkers & Prevention.

Andrew Rundle, DrPH, from Columbia University in New York, and colleagues examined the association of obesity with future prostate cancer risk in 494 men who had undergone benign biopsy or transurethral resection of the prostate and 494 matched controls. The researchers found that prostatic intraepithelial neoplasia (PIN) was present in 11% of the initial benign biopsies. Obesity at the time of the initial procedure was associated with a twofold increased risk of PIN in the initial biopsy and a 57% increased risk of PCa during follow-up, after adjusting for a number of variables. The higher PCa risk was only found in cases diagnosed earlier, with less than 1,538 days of follow-up.

"Obesity is associated with the presence of PIN in benign specimens and with future prostate cancer risk after an initial benign finding," Dr. Rundle and colleagues concluded.

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