High-Grade Prostate Cancer Linked to Low Testosterone
Hypogonadal men are more likely than those with normal testosterone to have prostate biopsy results showing high-grade PCa.
A team led by Hyeon Jeong, MD, of Seoul Metropolitan Government Seoul National University, retrospectively studied 681 men who underwent an initial 12-core transrectal prostate biopsy. Of these, 86 had low testosterone levels (less than 300 ng/dL) and 143 had normal levels (300 ng/dL or higher). In addition, 143 men had a positive biopsy and 99 had high-grade PCa.
In multivariable analysis, compared with a normal testosterone level, a low testosterone level was not significantly associated with a PCa diagnosis overall, but it was associated with a significant 2.1 times increased risk of high-grade PCa, the investigators reported online ahead of print in BJU International.
“Low testosterone level is an independent risk factor for high-grade prostate cancer detection at biopsy,” the researchers concluded. “Therefore, checking testosterone levels could help to determine whether prostate biopsy should be carried out.”