Chronic Prostate Inflammation Linked with High-Grade Cancer
Association seen even in men with low prostate-specific antigen levels.
The presence of chronic inflammation in benign prostate tissue samples is associated with prostate cancer, especially high-grade disease, according to a study published online in Cancer Epidemiology, Biomarkers & Prevention.
Bora Gurel, MD, of Johns Hopkins University in Baltimore, and colleagues sampled 191 prostate cancer cases (detected on a for-cause [clinically indicated] or end-of-study [protocol directed] biopsy), and 209 frequency-matched controls (negative for cancer on an end-of-study biopsy), participating in the placebo arm of the Prostate Cancer Prevention Trial. Visual assessments of inflammation prevalence and extent were made in benign areas of biopsy cores.
The researchers found that 86.2% of cases and 78.2% of controls had at least one biopsy core (of 3 assessed) with inflammation in benign areas, most of which was chronic. The odds of prostate cancer were 1.78 times higher in men who had at least one biopsy core with inflammation, compared with men who had zero cores with inflammation.
Men with high-grade disease (Gleason sum 7-10) had a 2.2 times greater risk. These findings remained when restricting to cases and controls in whom intraprostatic inflammation was the least likely to have influenced biopsy recommendation (PSA below 2 ng/mL at biopsy).
"Inflammation, most of which was chronic, was common in benign prostate tissue, and was positively associated with prostate cancer, especially high-grade," the authors wrote.