Bacteremia Often Caused by TURP
Researchers' results showed that the presence of a urinary catheter and recent antibiotic use were associated with increased odds of intra-operative bacteremia.
Asymptomatic bacteremia is commonly caused by transurethral resection of the prostate (TURP) and occurs despite prophylaxis, researchers concluded.
The findings challenge a common held view that urine is the primary source of bacteremia in TURP-associated sepsis and raise the possibility of occult prostatic infection as a cause of bacteraemia, according to Amar Raj Mohee, MBChB, of The Christie NHS Foundation Trust in Manchester, UK, and colleagues.
They investigators studied 73 TURP patients from whom 276 blood samples were obtained. Patients had a mean age of 72.7 years. Prior to surgery, patients received standard of care antibiotic prophylaxis.
No symptomatic bacteremia developed in any patient during the procedure, but asymptomatic bacteremia developed in 17 patients (23.2%). The most common organisms cultured were Enterococcus faecalis and Pseudomonas aeruginosa. Bacteremia was 5.38 and 6.46 times more likely to be detected at 10 and 20 minutes after the start of the procedure compared with compared with before the procedure, the investigators reported online in PLoS One.
The finding that bacteremia most often developed from 10 to 20 minutes after the start of TURP and less frequently after the end of the procedure suggests a causal relationship between TURP and bacteremia, according to the investigators. TURP, however, did not explain bacteremia in all patients because 3 patients were bacteremic prior to the start of the procedure.
Dr Mohee's group noted that 34 patients (46.6%) had preoperative bacteriuria, with E. faecalis the commonly cultured organism. Eleven of these patients (32.3%) did not have a urinary catheter in situ.
With respect to prostatic pathology, 20 patients (27.4%) had prostate cancer and 26 (35.6%) had evidence of prostatic inflammation. Patients with malignant histology had a 4.9 times increased likelihood of bacteremia than those without malignant histology.
Results also showed that the presence of a urinary catheter and recent antibiotic use were associated with 4.92 and 4.34 increased odds of intra-operative bacteremia, respectively.
The current study is the largest series to date to assess bacteremia in TURP patients, but the results may not be applicable to the general population undergoing TURP because the sample size is small, the researchers acknowledged. The incidence of bacteremia was lower than they expected, reducing the power to investigate risk factors, they noted.
The researchers also pointed out that only 54 of the 73 patients provided blood samples. Some patients did not proceed to surgery because of unavailability of a hospital bed or the anesthesiologist did not deem a patient fit for surgery. In addition, for patients who proceeded to surgery, the principal investigator was unable to gain venous access to obtain blood samples.