Prostate Cancer News Archive

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

In a study, systematic biopsy detected clinically significant prostate cancer in only 3% of men with negative findings on multiparametic MRI.

Adverse Effects of Treatment for Localized PCa Clarified

Adverse Effects of Treatment for Localized PCa Clarified

Findings from 2 new studies could enable more informed patient counseling about choice of therapy.

Nerve-sparing RP May Not Raise Positive Margin Risk

Nerve-sparing RP May Not Raise Positive Margin Risk

Researchers found no evidence of worse cancer outcomes with nerve-sparing surgery.

TRT Does Not Appear to Increase PCa Risk

TRT Does Not Appear to Increase PCa Risk

A population-based study showed no association between total prostate cancer risk and testosterone replacement therapy (TRT).

Bone Metastases Seldom Progress During Radium-223 Therapy

Bone Metastases Seldom Progress During Radium-223 Therapy

At 6 months of treatment, bone imaging showed stable disease in 94% of patients with available data, study finds.

Prostate MRI Quality May Improve With Bowel Prep

Prostate MRI Quality May Improve With Bowel Prep

In multiparametric magnetic resonance imaging, rectal distension have a negative effect on T2-weighted and diffusion-weighted images.

Targeted Biopsy Detects Gleason Score Upgrading in AS

Targeted Biopsy Detects Gleason Score Upgrading in AS

Men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading than men with an initial Gleason score of 3 + 3 at 3 years.

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

Clinical or radiologic progression is less likely with abiraterone plus prednisone than cabazitaxel following first-line docetaxel, study finds.

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

Study finds that PSA and PSAD indicated prostate cancer above Gleason score 6 for white men only.

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

In a retrospective study, patients lived the longest if they received docetaxel followed by cabazitaxel and then abiraterone or enzalutamide.

Urologists Support Targeted Biopsy

Urologists Support Targeted Biopsy

In a survey, 3 in 5 urologists in the United States indicated they perform MRI-US guided biopsy in current practice.

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

From 1995 to 2011, prostate cancer deaths fell by 13.0% among Danish patients diagnosed with low-risk disease.

Prostate Cancer Treatment Prolongs Survival

Prostate Cancer Treatment Prolongs Survival

Study compared PCa patients who underwent surgery or radiation treatment with a matched group of non-cancer controls.

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

In a study, each 1-unit increment in body mass index was associated with a 16% lower mortality risk.

Black Patients May Be Adversely Affected by Less PSA Screening

Black Patients May Be Adversely Affected by Less PSA Screening

Black patients who met age criteria for PSA screening were 28% more likely to die of their prostate cancer than patients ineligible for screening.

Metastatic Prostate Cancer Death Rates Declining

Metastatic Prostate Cancer Death Rates Declining

Cancer-specific mortality rates dropped from 72.8% in 1995 to 55.8% in 2011, according to a Danish study.

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Researchers compared targeted prostate biopsy based on biparametric magnetic resonance imaging with standard 12-core systematic biopsy.

Cancer Mortality Rate Declining in the US

Cancer Mortality Rate Declining in the US

Cancer mortality decreased by 20.1% between 1980 and 2014, from 240.2 to 192.0 deaths per 100 000 population.

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

Combined treatment for recurrent prostate cancer after radical prostatectomy results in decreased long-term all-cause and cancer-specific mortality.

Urologists' Use of Observation for PCa Raises Concern

Urologists' Use of Observation for PCa Raises Concern

For individual urologists, the probability of using observation for low-risk disease ranged widely from 5.1% to 71.2%.

Targeted Biopsy Improves Detection of Significant PCa in Black Men

Targeted Biopsy Improves Detection of Significant PCa in Black Men

Targeted biopsy should be considered for grade 4-5 lesions on the Likert scale, researchers say.

Anxiety, Depression May Up Death Risk for Prostate Cancer

Anxiety, Depression May Up Death Risk for Prostate Cancer

Higher death rates found in cancers not related to smoking, carcinoma of the colorectum, prostate, pancreas, oesophagus, and leukemia.

Antidiabetic Drug Use May Cut PCa Risk

Antidiabetic Drug Use May Cut PCa Risk

The results suggest that hyperinsulinemia may be a risk factor for prostate cancer.

Asians With Metastatic Prostate Cancer Have Better Survival

Asians With Metastatic Prostate Cancer Have Better Survival

The median OS differed by race, with superior OS observed among Asian men than among men of other races.

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Using imaging to triage men with elevated PSA might avoid a quarter of unnecessary biopsies, according to a study.

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

No benefit of autologous urethral sling placement at robotic assisted radical prostatectomy on early return of continence at 6 months.

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Prostate Cancer Death Rate Fell in the United States

Prostate Cancer Death Rate Fell in the United States

The investigators found that the cancer mortality rate hit its peak in 1991, before beginning a steady slide of roughly 1.5% per year among both men and women through 2014.

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

The proportions of skeletal-related events did not differ significantly between the every 4-week dosing group vs the every 12-week dosing group of bone metastases patients.

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate atrophy in more cores also was associated with lower risks of low- and high-grade disease.

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

In a study, 53.1% of patients had concomitant prostate cancer in radical cystectomy specimens.

New Prostate Cancer Grading System Validated

New Prostate Cancer Grading System Validated

Proposed 5-tiered system found to predict the risk of prostate cancer-specific mortality.

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Patients on active surveillance with stable disease at the time of initial surveillance prostate biopsy may be appropriate candidates for less intensive surveillance prostate biopsy schedules.

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Mutation carrier status was associated with earlier death and among lethal prostate cancer patients (age 67 vs 72 in non-carriers) and shorter survival.

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

In patients undergoing confirmatory biopsy for active surveillance, MRI can increase detection of clinically significant tumors compared with standard systematic biopsy.

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 methylation was increased in tumor-positive biopsies.

Prostate Cancer Active Surveillance Criteria May Need Updating

Prostate Cancer Active Surveillance Criteria May Need Updating

When MRI-US fusion biopsy is added to the standard 12-core biopsy, the number of men eligible for active surveillance decreases, study finds.

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Magnetic resonance imaging of the prostate missed 13% of high-grade cancers that were later found on transrectal ultrasound-guided biopsy.

Radium-223 Reduces Hospital Usage for Skeletal Events

Radium-223 Reduces Hospital Usage for Skeletal Events

CRPC patients treated with radium-223 spent fewer days in the hospital both before and after a skeletal event compared with placebo recipients.

Aggressive Prostate Cancer Diagnoses Declining in US

Aggressive Prostate Cancer Diagnoses Declining in US

Study of men diagnosed with PCa from 2008 to 2013 found declining incidence among whites, blacks, Hispanics, and Asian/Pacific Islanders.

New Prostate Cancer Grading System Predicts Survival After RP

New Prostate Cancer Grading System Predicts Survival After RP

Study shows a significant difference in all-cause and cancer-specific mortality between Gleason score 8 and Gleason score 9-10 disease.

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Obesity predicts a wider range of complications in PCa patients who undergo laparoscopic or robot-assisted versus open radical prostatectomy.

CTCs May Aid Prostate Cancer Risk Stratification

CTCs May Aid Prostate Cancer Risk Stratification

Analysis of circulating tumor cells may help identify patients at higher risk of biochemical recurrence after treatment.

PCa Cryoablation Achieves Acceptable Outcomes

PCa Cryoablation Achieves Acceptable Outcomes

In a study, the 5-year estimated biochemical failure-free survival rate, based on the Phoenix definition, was 84%.

Infections After Prostate Biopsy Continue to Rise

Infections After Prostate Biopsy Continue to Rise

Patients are at higher risk with the transrectal rather than transperineal approach.

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

The researchers observed no significant changes in intervention outcomes or in engagement with mindfulness for men with PC.

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

No increased risk of dementia for androgen deprivation therapy use versus nonuse.

Prostate Cancer Incidence Lower in HIV-Infected Men

Prostate Cancer Incidence Lower in HIV-Infected Men

HIV-infected men and women had lower incidences of colorectal and lung cancer compared with the general population.

Cancer Patients Benefit From Exercise During, After Treatment

Cancer Patients Benefit From Exercise During, After Treatment

At the end of 3 months, the exercise and diet group was walking 3 to 4 times more quickly in a timed walk test of about a quarter-mile than the usual care group.

Study: 5-ARIs Do Not Increase PCa Death Risk

Study: 5-ARIs Do Not Increase PCa Death Risk

New findings confirm previous reports.

Guidelines Developed for Prostate MRI After Negative Biopsy

Guidelines Developed for Prostate MRI After Negative Biopsy

High-quality prostate MRI should be strongly considered for any patient with a prior negative biopsy who is under evaluation for a repeat biopsy.

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

Second Opinions Rarely Alter PCa Treatment Decisions

Second Opinions Rarely Alter PCa Treatment Decisions

Obtaining second opinions was not associated with changes in treatment choice or with improvements in how patients viewed their quality of cancer care.

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Following the 2012 USPSTF recommendation against PSA screening in populations, rates of radical prostatectomy and biopsy have become significantly less common.

Biases Suspected in Prostate Cancer Risk Estimates

Biases Suspected in Prostate Cancer Risk Estimates

Incident prostate cancer cohorts were defined by examining men who were regularly screened from the placebo arms of two large prostate cancer prevention trials.

PSA Error in the SEER Database Lower Than Suspected

PSA Error in the SEER Database Lower Than Suspected

The error rate due to the implied decimal point used for prostate-specific antigen (PSA) results is substantially lower than previously noted.

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

New findings have potential implications regarding patient selection for active surveillance.

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices for patients with type 2 diabetes.

Exercise Training Improves Quality of Life for PCa Patients

Exercise Training Improves Quality of Life for PCa Patients

Patient motivation is pivotal to the success of exercise interventions, researchers noted.

Higher Grade PCa Found After AS vs Immediate RP

Higher Grade PCa Found After AS vs Immediate RP

Patients with low-risk prostate cancer who enter active surveillance have higher grade disease at prostatectomy.

Prostate Cancer Active Surveillance Rates Highest in Sweden

Prostate Cancer Active Surveillance Rates Highest in Sweden

In 2014, 91% of Swedish men with very low risk prostate cancer opted for active surveillance.

FDA Approves Enzalutamide Labeling Update

FDA Approves Enzalutamide Labeling Update

Labeling information will include data showing the drug reduces the risk of radiographic progression versus bicalutamide.

Smokeless Tobacco May Increase Prostate Cancer Mortality

Smokeless Tobacco May Increase Prostate Cancer Mortality

Smokeless tobacco "snus" users have high blood levels of nicotine which promotes cancer progression.

New Prostate Cancer Screening Algorithm Proposed

New Prostate Cancer Screening Algorithm Proposed

A PSA level of 1.5 ng/mL or higher should prompt primary care physicians to refer patients to a urologist for further evaluation.

Dementia Linked to Prostate Cancer ADT

Dementia Linked to Prostate Cancer ADT

The risk of dementia was 2-fold higher among ADT users.

Ipilimumab Does Not Increase Overall Survival in mCRPC

Ipilimumab Does Not Increase Overall Survival in mCRPC

A phase 3 study of ipilimumab among patients with metastatic, castration-resistant prostate cancer (mCRPC) did not meet its primary endpoint.

Alisertib May Help Treat Neuroendocrine Prostate Cancer

Alisertib May Help Treat Neuroendocrine Prostate Cancer

NEPC is an aggressive subtype of castration-resistant prostate cancer independent of androgen expression.

Obesity Linked With Prostate Cancer Death

Obesity Linked With Prostate Cancer Death

A body mass index of 30 kg/m2 or higher was was associated with 2-fold increased risk of dying from prostate cancer.

Therapeutic Sequences for mCRPC Probed

Therapeutic Sequences for mCRPC Probed

Researchers demonstrate a possible survival advantage by including cabazitaxel in sequences of new agents in the post-docetaxel setting.

Prostate Cancer Progression Risk Lower With Initial Degarelix Use

Prostate Cancer Progression Risk Lower With Initial Degarelix Use

Pooled analysis shows initial use of degarelix versus LHRH agonists was associated with improved PSA progression-free survival.

ALP Decline in Radium-223 Recipients Predicts Better Outcomes

ALP Decline in Radium-223 Recipients Predicts Better Outcomes

In a study, a drop in alkaline phosphatase level at 12 weeks compared with baseline was associated with a decreased risk of death and first symptomatic skeletal event.

Radiographic Progression of mCRPC Without Rising PSA

Radiographic Progression of mCRPC Without Rising PSA

In a PREVAIL trial post hoc analysis, nearly one fourth of men on enzalutamide had radiographic progression despite non-rising PSA.

PCa Deaths Rare Among Men With Benign 1st Biopsy and Low PSA

PCa Deaths Rare Among Men With Benign 1st Biopsy and Low PSA

After 20 years, the prostate cancer mortality rate was 0.7% for men with a PSA level of 10 ng/mL or less and benign initial biopsy results.

Use Metastasis-Free Survival as Proxy in Localized PCa Trials

Use Metastasis-Free Survival as Proxy in Localized PCa Trials

Metastasis-free survival correlates with overall survival in localized prostate cancer clinical trials.

Prostate Cancer BCR Risk Not Linked to Statin Use

Prostate Cancer BCR Risk Not Linked to Statin Use

Over a median follow-up of 70 months, 15% of men studied experienced biochemical recurrence.

Racial Disparities Found in Prostate Cancer Treatment

Racial Disparities Found in Prostate Cancer Treatment

Within each D'Amico risk category, African-American and Hispanic prostate cancer patients were less likely to receive definitive treatment than white patients.

Defining Deliverables of PCa Fusion-Targeted Biopsy

Defining Deliverables of PCa Fusion-Targeted Biopsy

Two new equations could better descriminate between clinical significant and indolent prostate cancer

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Results show that mpMRI and PI-RADSv2 score have a greater ability to detect prostate cancer progression after TRT compared with PSA.

No Survival Benefit for EBT With Brachytherapy in Intermediate PCa

No Survival Benefit for EBT With Brachytherapy in Intermediate PCa

Addition of external beam therapy doesn't improve 5-year progression-free survival in prostate cancet

Hypertension May Raise Prostate Cancer Risk

Hypertension May Raise Prostate Cancer Risk

Data from 21 observational studies showed an 8% increased risk of prostate cancer.

10-Year Mortality for Localized PCa Does Not Differ by Treatment Choice

10-Year Mortality for Localized PCa Does Not Differ by Treatment Choice

Ten-year mortality rates of prostate cancer are low, regardless of whether patients are treated with radiotherapy, surgery, or undergo only active surveillance.

Digital Rectal Examination, PSA Testing Rates Declining

Digital Rectal Examination, PSA Testing Rates Declining

Decreases in use of screening following USPSTF recommendations against routine PSA screening.

Vasectomy Unlikely to Increase Prostate Cancer Risk, Mortality

Vasectomy Unlikely to Increase Prostate Cancer Risk, Mortality

Large study challenges previous research linking the procedure to slightly higher chance of disease.

Urinary, Sexual Function Recovery Differs by Localized PCa Treatment

Urinary, Sexual Function Recovery Differs by Localized PCa Treatment

Urinary, bowel, sexual function, and quality of life among men with prostate cancer may vary depending on treatment type.

Bacteremia Often Caused by TURP

Bacteremia Often Caused by TURP

Researchers' results showed that the presence of a urinary catheter and recent antibiotic use were associated with increased odds of intra-operative bacteremia.

Adding Zoledronic Acid to ADT Does Not Delay PCa Treatment Failure

Adding Zoledronic Acid to ADT Does Not Delay PCa Treatment Failure

Study tested the combination in men with treatment-naïve prostate cancer and bone metastasis.

PSA Failure Predicts Death in Men With Low Comorbidity Burden

PSA Failure Predicts Death in Men With Low Comorbidity Burden

Findings among men with localized intermediate- and high-risk prostate cancer.

Metastatic PCa Is On the Rise

Metastatic PCa Is On the Rise

Between 2007 to 2013, the incidence of metastatic PCa increased by 7.1% annually.

PCa Treatment Can Relieve Pre-Existing LUTS

PCa Treatment Can Relieve Pre-Existing LUTS

Patients' pre-existing urinary problems influenced their perceptions of symptom relief after prostate cancer treatment.

Long-term ADT Use Not Linked With Cognitive Decline

Long-term ADT Use Not Linked With Cognitive Decline

Ongoing use of androgen-deprivation therapy (ADT) for up to 36 months is not associated with cognitive decline among men with prostate cancer.

Genetic Variant in Prostate Cancer Patients May Predict ADT Failure

Genetic Variant in Prostate Cancer Patients May Predict ADT Failure

Men with 1 or 2 copies of the HSD3B1 (1245C) allele are more likely to experience disease progression.

Treatment-Related Hospitalizations Similar for PCa Surgery, Radiation

Treatment-Related Hospitalizations Similar for PCa Surgery, Radiation

The odds were 16% lower for men who underwent external beam radiotherapy/intensity modulated radiation therapy, however.

Prostate Cancer Death Rate Higher Among Blacks in Most Big Cities

Prostate Cancer Death Rate Higher Among Blacks in Most Big Cities

Greatest racial disparity found in Los Angeles, the least in Minneapolis.

High-Risk PCa Found in Black Men Initially on Active Surveillance

High-Risk PCa Found in Black Men Initially on Active Surveillance

Even black men with relatively few comorbidities had increased risks of upgrading or upstaging compared with non-black patients.

Fewer Early PCa Diagnoses Following USPSTF Recs

Fewer Early PCa Diagnoses Following USPSTF Recs

Early prostate cancer diagnosis rates fell, while cases of advanced prostate cancer remained stable.

Treatment Regret Infrequent After Radical Prostatectomy, IMRT

Treatment Regret Infrequent After Radical Prostatectomy, IMRT

Overall decision regret for 16.9% of patients; more regret for RP than radiotherapy component.

Radium-223 With Concomitant Therapy May Prolong Life With mCRPC

Radium-223 With Concomitant Therapy May Prolong Life With mCRPC

Survival was longer in patients who received radium-223 plus abiraterone, enzalutamide, or both.

High-Grade Prostate Cancer Linked to Diabetes Drugs

High-Grade Prostate Cancer Linked to Diabetes Drugs

Men who used the medications prior to radical prostatectomy had 83% greater odds of Gleason 7-10 tumors compared with non-users.

Radical Local Therapy Offers Mortality Benefit in Very High-Risk PCa

Radical Local Therapy Offers Mortality Benefit in Very High-Risk PCa

Prostatectomy and radiotherapy with or without ADT reduced prostate cancer-specific and all-cause mortality rates.

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