Prostate Cancer News Archive

Anxiety, Depression May Up Death Risk for Prostate Cancer

Anxiety, Depression May Up Death Risk for Prostate Cancer

Higher death rates found in cancers not related to smoking, carcinoma of the colorectum, prostate, pancreas, oesophagus, and leukemia.

Antidiabetic Drug Use May Cut PCa Risk

Antidiabetic Drug Use May Cut PCa Risk

The results suggest that hyperinsulinemia may be a risk factor for prostate cancer.

Asians With Metastatic Prostate Cancer Have Better Survival

Asians With Metastatic Prostate Cancer Have Better Survival

The median OS differed by race, with superior OS observed among Asian men than among men of other races.

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Using imaging to triage men with elevated PSA might avoid a quarter of unnecessary biopsies, according to a study.

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

No benefit of autologous urethral sling placement at robotic assisted radical prostatectomy on early return of continence at 6 months.

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Prostate Cancer Death Rate Fell in the United States

Prostate Cancer Death Rate Fell in the United States

The investigators found that the cancer mortality rate hit its peak in 1991, before beginning a steady slide of roughly 1.5% per year among both men and women through 2014.

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

The proportions of skeletal-related events did not differ significantly between the every 4-week dosing group vs the every 12-week dosing group of bone metastases patients.

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate atrophy in more cores also was associated with lower risks of low- and high-grade disease.

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

In a study, 53.1% of patients had concomitant prostate cancer in radical cystectomy specimens.

New Prostate Cancer Grading System Validated

New Prostate Cancer Grading System Validated

Proposed 5-tiered system found to predict the risk of prostate cancer-specific mortality.

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Patients on active surveillance with stable disease at the time of initial surveillance prostate biopsy may be appropriate candidates for less intensive surveillance prostate biopsy schedules.

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Mutation carrier status was associated with earlier death and among lethal prostate cancer patients (age 67 vs 72 in non-carriers) and shorter survival.

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

In patients undergoing confirmatory biopsy for active surveillance, MRI can increase detection of clinically significant tumors compared with standard systematic biopsy.

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 methylation was increased in tumor-positive biopsies.

Prostate Cancer Active Surveillance Criteria May Need Updating

Prostate Cancer Active Surveillance Criteria May Need Updating

When MRI-US fusion biopsy is added to the standard 12-core biopsy, the number of men eligible for active surveillance decreases, study finds.

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Magnetic resonance imaging of the prostate missed 13% of high-grade cancers that were later found on transrectal ultrasound-guided biopsy.

Radium-223 Reduces Hospital Usage for Skeletal Events

Radium-223 Reduces Hospital Usage for Skeletal Events

CRPC patients treated with radium-223 spent fewer days in the hospital both before and after a skeletal event compared with placebo recipients.

Aggressive Prostate Cancer Diagnoses Declining in US

Aggressive Prostate Cancer Diagnoses Declining in US

Study of men diagnosed with PCa from 2008 to 2013 found declining incidence among whites, blacks, Hispanics, and Asian/Pacific Islanders.

New Prostate Cancer Grading System Predicts Survival After RP

New Prostate Cancer Grading System Predicts Survival After RP

Study shows a significant difference in all-cause and cancer-specific mortality between Gleason score 8 and Gleason score 9-10 disease.

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Obesity predicts a wider range of complications in PCa patients who undergo laparoscopic or robot-assisted versus open radical prostatectomy.

CTCs May Aid Prostate Cancer Risk Stratification

CTCs May Aid Prostate Cancer Risk Stratification

Analysis of circulating tumor cells may help identify patients at higher risk of biochemical recurrence after treatment.

PCa Cryoablation Achieves Acceptable Outcomes

PCa Cryoablation Achieves Acceptable Outcomes

In a study, the 5-year estimated biochemical failure-free survival rate, based on the Phoenix definition, was 84%.

Infections After Prostate Biopsy Continue to Rise

Infections After Prostate Biopsy Continue to Rise

Patients are at higher risk with the transrectal rather than transperineal approach.

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

Mindfulness-Based Cognitive Therapy Ineffective in Advanced PCa

The researchers observed no significant changes in intervention outcomes or in engagement with mindfulness for men with PC.

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Survival Benefit Linked With Adjuvant RT+ADT in Lymph Node + PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

ADT Not Linked to Dementia in Nonmetastatic Prostate Cancer

No increased risk of dementia for androgen deprivation therapy use versus nonuse.

Prostate Cancer Incidence Lower in HIV-Infected Men

Prostate Cancer Incidence Lower in HIV-Infected Men

HIV-infected men and women had lower incidences of colorectal and lung cancer compared with the general population.

Cancer Patients Benefit From Exercise During, After Treatment

Cancer Patients Benefit From Exercise During, After Treatment

At the end of 3 months, the exercise and diet group was walking 3 to 4 times more quickly in a timed walk test of about a quarter-mile than the usual care group.

Study: 5-ARIs Do Not Increase PCa Death Risk

Study: 5-ARIs Do Not Increase PCa Death Risk

New findings confirm previous reports.

Guidelines Developed for Prostate MRI After Negative Biopsy

Guidelines Developed for Prostate MRI After Negative Biopsy

High-quality prostate MRI should be strongly considered for any patient with a prior negative biopsy who is under evaluation for a repeat biopsy.

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Adjuvant RT+ADT Linked With Survival Advantage in Lymph Node Positive PCa

Radiation treatment plus androgen deprivation therapy (ADT) after radical prostatectomy was associated with an overall survival benefit.

Second Opinions Rarely Alter PCa Treatment Decisions

Second Opinions Rarely Alter PCa Treatment Decisions

Obtaining second opinions was not associated with changes in treatment choice or with improvements in how patients viewed their quality of cancer care.

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Fewer Prostate Biopsies After USPSTF Limited PSA Screening

Following the 2012 USPSTF recommendation against PSA screening in populations, rates of radical prostatectomy and biopsy have become significantly less common.

Biases Suspected in Prostate Cancer Risk Estimates

Biases Suspected in Prostate Cancer Risk Estimates

Incident prostate cancer cohorts were defined by examining men who were regularly screened from the placebo arms of two large prostate cancer prevention trials.

PSA Error in the SEER Database Lower Than Suspected

PSA Error in the SEER Database Lower Than Suspected

The error rate due to the implied decimal point used for prostate-specific antigen (PSA) results is substantially lower than previously noted.

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

Hypogonadism Ups Progression Risk in Men With Low-Risk PCa

New findings have potential implications regarding patient selection for active surveillance.

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Statins Curb Insulin-Related Cancer Risk in Diabetes Patients

Insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices for patients with type 2 diabetes.

Exercise Training Improves Quality of Life for PCa Patients

Exercise Training Improves Quality of Life for PCa Patients

Patient motivation is pivotal to the success of exercise interventions, researchers noted.

Higher Grade PCa Found After AS vs Immediate RP

Higher Grade PCa Found After AS vs Immediate RP

Patients with low-risk prostate cancer who enter active surveillance have higher grade disease at prostatectomy.

Prostate Cancer Active Surveillance Rates Highest in Sweden

Prostate Cancer Active Surveillance Rates Highest in Sweden

In 2014, 91% of Swedish men with very low risk prostate cancer opted for active surveillance.

FDA Approves Enzalutamide Labeling Update

FDA Approves Enzalutamide Labeling Update

Labeling information will include data showing the drug reduces the risk of radiographic progression versus bicalutamide.

Smokeless Tobacco May Increase Prostate Cancer Mortality

Smokeless Tobacco May Increase Prostate Cancer Mortality

Smokeless tobacco "snus" users have high blood levels of nicotine which promotes cancer progression.

New Prostate Cancer Screening Algorithm Proposed

New Prostate Cancer Screening Algorithm Proposed

A PSA level of 1.5 ng/mL or higher should prompt primary care physicians to refer patients to a urologist for further evaluation.

Dementia Linked to Prostate Cancer ADT

Dementia Linked to Prostate Cancer ADT

The risk of dementia was 2-fold higher among ADT users.

Ipilimumab Does Not Increase Overall Survival in mCRPC

Ipilimumab Does Not Increase Overall Survival in mCRPC

A phase 3 study of ipilimumab among patients with metastatic, castration-resistant prostate cancer (mCRPC) did not meet its primary endpoint.

Alisertib May Help Treat Neuroendocrine Prostate Cancer

Alisertib May Help Treat Neuroendocrine Prostate Cancer

NEPC is an aggressive subtype of castration-resistant prostate cancer independent of androgen expression.

Obesity Linked With Prostate Cancer Death

Obesity Linked With Prostate Cancer Death

A body mass index of 30 kg/m2 or higher was was associated with 2-fold increased risk of dying from prostate cancer.

Therapeutic Sequences for mCRPC Probed

Therapeutic Sequences for mCRPC Probed

Researchers demonstrate a possible survival advantage by including cabazitaxel in sequences of new agents in the post-docetaxel setting.

Prostate Cancer Progression Risk Lower With Initial Degarelix Use

Prostate Cancer Progression Risk Lower With Initial Degarelix Use

Pooled analysis shows initial use of degarelix versus LHRH agonists was associated with improved PSA progression-free survival.

ALP Decline in Radium-223 Recipients Predicts Better Outcomes

ALP Decline in Radium-223 Recipients Predicts Better Outcomes

In a study, a drop in alkaline phosphatase level at 12 weeks compared with baseline was associated with a decreased risk of death and first symptomatic skeletal event.

Radiographic Progression of mCRPC Without Rising PSA

Radiographic Progression of mCRPC Without Rising PSA

In a PREVAIL trial post hoc analysis, nearly one fourth of men on enzalutamide had radiographic progression despite non-rising PSA.

PCa Deaths Rare Among Men With Benign 1st Biopsy and Low PSA

PCa Deaths Rare Among Men With Benign 1st Biopsy and Low PSA

After 20 years, the prostate cancer mortality rate was 0.7% for men with a PSA level of 10 ng/mL or less and benign initial biopsy results.

Use Metastasis-Free Survival as Proxy in Localized PCa Trials

Use Metastasis-Free Survival as Proxy in Localized PCa Trials

Metastasis-free survival correlates with overall survival in localized prostate cancer clinical trials.

Prostate Cancer BCR Risk Not Linked to Statin Use

Prostate Cancer BCR Risk Not Linked to Statin Use

Over a median follow-up of 70 months, 15% of men studied experienced biochemical recurrence.

Racial Disparities Found in Prostate Cancer Treatment

Racial Disparities Found in Prostate Cancer Treatment

Within each D'Amico risk category, African-American and Hispanic prostate cancer patients were less likely to receive definitive treatment than white patients.

Defining Deliverables of PCa Fusion-Targeted Biopsy

Defining Deliverables of PCa Fusion-Targeted Biopsy

Two new equations could better descriminate between clinical significant and indolent prostate cancer

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Study: mpMRI Findings in Prostate Cancer Patients Unaffected by TRT

Results show that mpMRI and PI-RADSv2 score have a greater ability to detect prostate cancer progression after TRT compared with PSA.

No Survival Benefit for EBT With Brachytherapy in Intermediate PCa

No Survival Benefit for EBT With Brachytherapy in Intermediate PCa

Addition of external beam therapy doesn't improve 5-year progression-free survival in prostate cancet

Hypertension May Raise Prostate Cancer Risk

Hypertension May Raise Prostate Cancer Risk

Data from 21 observational studies showed an 8% increased risk of prostate cancer.

10-Year Mortality for Localized PCa Does Not Differ by Treatment Choice

10-Year Mortality for Localized PCa Does Not Differ by Treatment Choice

Ten-year mortality rates of prostate cancer are low, regardless of whether patients are treated with radiotherapy, surgery, or undergo only active surveillance.

Digital Rectal Examination, PSA Testing Rates Declining

Digital Rectal Examination, PSA Testing Rates Declining

Decreases in use of screening following USPSTF recommendations against routine PSA screening.

Vasectomy Unlikely to Increase Prostate Cancer Risk, Mortality

Vasectomy Unlikely to Increase Prostate Cancer Risk, Mortality

Large study challenges previous research linking the procedure to slightly higher chance of disease.

Urinary, Sexual Function Recovery Differs by Localized PCa Treatment

Urinary, Sexual Function Recovery Differs by Localized PCa Treatment

Urinary, bowel, sexual function, and quality of life among men with prostate cancer may vary depending on treatment type.

Bacteremia Often Caused by TURP

Bacteremia Often Caused by TURP

Researchers' results showed that the presence of a urinary catheter and recent antibiotic use were associated with increased odds of intra-operative bacteremia.

Adding Zoledronic Acid to ADT Does Not Delay PCa Treatment Failure

Adding Zoledronic Acid to ADT Does Not Delay PCa Treatment Failure

Study tested the combination in men with treatment-naïve prostate cancer and bone metastasis.

PSA Failure Predicts Death in Men With Low Comorbidity Burden

PSA Failure Predicts Death in Men With Low Comorbidity Burden

Findings among men with localized intermediate- and high-risk prostate cancer.

Metastatic PCa Is On the Rise

Metastatic PCa Is On the Rise

Between 2007 to 2013, the incidence of metastatic PCa increased by 7.1% annually.

PCa Treatment Can Relieve Pre-Existing LUTS

PCa Treatment Can Relieve Pre-Existing LUTS

Patients' pre-existing urinary problems influenced their perceptions of symptom relief after prostate cancer treatment.

Long-term ADT Use Not Linked With Cognitive Decline

Long-term ADT Use Not Linked With Cognitive Decline

Ongoing use of androgen-deprivation therapy (ADT) for up to 36 months is not associated with cognitive decline among men with prostate cancer.

Genetic Variant in Prostate Cancer Patients May Predict ADT Failure

Genetic Variant in Prostate Cancer Patients May Predict ADT Failure

Men with 1 or 2 copies of the HSD3B1 (1245C) allele are more likely to experience disease progression.

Treatment-Related Hospitalizations Similar for PCa Surgery, Radiation

Treatment-Related Hospitalizations Similar for PCa Surgery, Radiation

The odds were 16% lower for men who underwent external beam radiotherapy/intensity modulated radiation therapy, however.

Prostate Cancer Death Rate Higher Among Blacks in Most Big Cities

Prostate Cancer Death Rate Higher Among Blacks in Most Big Cities

Greatest racial disparity found in Los Angeles, the least in Minneapolis.

High-Risk PCa Found in Black Men Initially on Active Surveillance

High-Risk PCa Found in Black Men Initially on Active Surveillance

Even black men with relatively few comorbidities had increased risks of upgrading or upstaging compared with non-black patients.

Fewer Early PCa Diagnoses Following USPSTF Recs

Fewer Early PCa Diagnoses Following USPSTF Recs

Early prostate cancer diagnosis rates fell, while cases of advanced prostate cancer remained stable.

Treatment Regret Infrequent After Radical Prostatectomy, IMRT

Treatment Regret Infrequent After Radical Prostatectomy, IMRT

Overall decision regret for 16.9% of patients; more regret for RP than radiotherapy component.

Radium-223 With Concomitant Therapy May Prolong Life With mCRPC

Radium-223 With Concomitant Therapy May Prolong Life With mCRPC

Survival was longer in patients who received radium-223 plus abiraterone, enzalutamide, or both.

High-Grade Prostate Cancer Linked to Diabetes Drugs

High-Grade Prostate Cancer Linked to Diabetes Drugs

Men who used the medications prior to radical prostatectomy had 83% greater odds of Gleason 7-10 tumors compared with non-users.

Radical Local Therapy Offers Mortality Benefit in Very High-Risk PCa

Radical Local Therapy Offers Mortality Benefit in Very High-Risk PCa

Prostatectomy and radiotherapy with or without ADT reduced prostate cancer-specific and all-cause mortality rates.

Adjuvant ADT May Up Mortality in Black Prostate Cancer Patients

Adjuvant ADT May Up Mortality in Black Prostate Cancer Patients

Androgen deprivation increased all-cause mortality risk by 77% among black men who underwent brachytherapy for favorable-risk prostate cancer.

Selenium May Cut Aggressive Prostate Cancer Risk

Selenium May Cut Aggressive Prostate Cancer Risk

An analysis of individual participant data from 15 prospective studies suggests a protective effect.

ED Drugs May Not Reduce Prostate Cancer Risk

ED Drugs May Not Reduce Prostate Cancer Risk

Prostate cancer was diagnosed in 19.5% of PDE5i users vs 22.7% of nonusers, a statistically insignificant difference.

Skeletal-Related Events Predict Higher Mortality in mCRPC

Skeletal-Related Events Predict Higher Mortality in mCRPC

Skeletal-related events occurred in 38% of patients with metastatic castration-resistant prostate cancer.

Intestinal Autoimmunity Possibly Linked to ADT

Intestinal Autoimmunity Possibly Linked to ADT

ADT for prostate cancer may be associated with a reduced risk of inflammatory bowel disease.

Identity Factors Influence Prostate Cancer Treatment Method

Identity Factors Influence Prostate Cancer Treatment Method

Ethnicity, education identified as factors that influence patients treatment decisions.

Obesity Common in Cancer Survivors

Obesity Common in Cancer Survivors

Prevalence of obesity is high in adults with a history of breast, prostate, or colorectal cancer.

Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, Surgery

Survival Outcomes in Gleason 9-10 PCa Similar With Radiation, Surgery

External beam radiation therapy (EBRT) plus brachytherapy found to offer improved systemic control versus EBRT alone and radical prostatectomy.

Robotic, Open Prostate Cancer Surgery Offer Similar Early Results

Robotic, Open Prostate Cancer Surgery Offer Similar Early Results

No significant differences observed in standard oncologic outcomes and quality of life at 12 weeks.

Race Affects Switch From Prostate Cancer Observation to Active Therapy

Race Affects Switch From Prostate Cancer Observation to Active Therapy

Blacks found to be slightly more likely than whites to leave observational management to undergo radiotherapy or surgery.

PCa Active Surveillance Patients Enjoy Good Quality of Life

PCa Active Surveillance Patients Enjoy Good Quality of Life

Study finds no greater burden from untreated cancer among active surveillance patients.

Prostate Cancer Mortality Rate Highest Among Older Men

Prostate Cancer Mortality Rate Highest Among Older Men

Three quarters of PCa deaths occur among men diagnosed with the disease when they are 70 to 89 years old.

No Survival Benefit With Cabozantinib in Progressive mCRPC

No Survival Benefit With Cabozantinib in Progressive mCRPC

Cabozantinib did not increase survival of heavily treated patients with mCRPC, compared with prednisone.

Metastatic Prostate Cancer Cases Increasing

Metastatic Prostate Cancer Cases Increasing

Research emphasizes the need for nationwide refinements in the prostate cancer screening process.

PD-1 Blockade Shows Promise for mCRPC

PD-1 Blockade Shows Promise for mCRPC

In a small study, some men whose cancer progressed while on enzalutamide had a profound PSA response to pembrolizumab.

Prostate Multiparametric MRI Feasible for PCa Screening

Prostate Multiparametric MRI Feasible for PCa Screening

Adjusted odds ratio of prostate cancer significantly higher for MRI score than PSA.

Robot-Assisted Prostate Surgery Safe, Effective Long Term

Robot-Assisted Prostate Surgery Safe, Effective Long Term

Largest Asian series to date shows a 5-year biochemical recurrence-free survival rate of 76.4%.

Familial Risk of Aggressive Prostate Cancer Quantified

Familial Risk of Aggressive Prostate Cancer Quantified

Swedish researchers say their findings are more useful for counseling men with a family history of prostate cancer.

Prostate Cancer Patients Taking Statins Lived Longer

Prostate Cancer Patients Taking Statins Lived Longer

Study results strengthen researchers' arguments for further clinical trials evaluating the potential protective effect of statins.

PI3K Pathway Aberrations May Reveal Targeted Therapy Opportunities

PI3K Pathway Aberrations May Reveal Targeted Therapy Opportunities

Combination therapies targeting both mutations in the PI3K pathway and HER2 or hormone receptor overexpression should be evaluated, researchers say.

Benign Tissue Changes May Help Predict Post-RP Biochemical Recurrence

Benign Tissue Changes May Help Predict Post-RP Biochemical Recurrence

Preliminary findings suggest a field effect in prostate cancer.

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