Prostate Cancer News Archive

Germline Mutations Up in PCa Patients With Another Primary Cancer

Germline Mutations Up in PCa Patients With Another Primary Cancer

Men with prostate cancer and at least one additional primary cancer are enriched for harboring a germline deleterious mutation in a cancer-predisposing gene.

Radical Prostatectomy Use for High-Risk Prostate Cancer Rises Sharply

Radical Prostatectomy Use for High-Risk Prostate Cancer Rises Sharply

Over a 10-year period, radical prostatectomy use increased steadily while radiotherapy use declined

Prostate Atrophy, Inflammation Associated With Lower PCa Risk

Prostate Atrophy, Inflammation Associated With Lower PCa Risk

Both findings on biopsy also predict a lower odds of high-grade cancer.

Negative Confirmatory Biopsy a Good Sign in Prostate Cancer AS

Negative Confirmatory Biopsy a Good Sign in Prostate Cancer AS

Prostate cancer patients on active surveillance who have no cancer found on confirmatory biopsy have a reduced risk of grade and volume reclassification.

PSA Testing in Controls of Screening Trial May Undermine Results

PSA Testing in Controls of Screening Trial May Undermine Results

Over 15 years of follow-up, considerable proportion of men undergo prostate-specific antigen testing

Novel Markers May Predict Prostate Cancer in Non-Black Men

Novel Markers May Predict Prostate Cancer in Non-Black Men

No added benefit was seen with the addition of biomarkers for African-American men.

Multimodal Therapy Found to Benefit Men With LN-positive PCa

Multimodal Therapy Found to Benefit Men With LN-positive PCa

New findings suggest that clinicians consider the pathologic characteristics of the primary tumor as well as the burden of LN metastases when deciding on management, investigators say.

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

Post-RP Radiotherapy Benefits Selected Men With Elevated PSA

Radiotherapy for prostate cancer patients with persistently elevated PSA after radical surgery improved survival only among those with worse pathologic characteristics.

High-income US Counties Have Higher Diagnoses of PCa

High-income US Counties Have Higher Diagnoses of PCa

High-income counties had far higher diagnosis rates for the four cancers than low-income counties, but the combined mortality rate was similar for both.

Survival Up With Patient-Reported Symptom Monitoring During Chemo

Survival Up With Patient-Reported Symptom Monitoring During Chemo

The researchers found that the median overall survival was 31.2 and 26.0 months in the PRO and usual care groups, respectively.

Men Need Better Understanding of PCa Genetic Test Results

Men Need Better Understanding of PCa Genetic Test Results

Some men who undergo multigene testing for inherited prostate cancer misinterpret findings of variants of uncertain significance.

Surgery May Offer Better Survival for Younger Men With High-risk PCa

Surgery May Offer Better Survival for Younger Men With High-risk PCa

Younger patients who chose surgery vs radiation for initial treatment had a 48% survival advantage.

Extended PLND Not Associated With Short-Term Oncologic Benefits

Extended PLND Not Associated With Short-Term Oncologic Benefits

Extended pelvic lymph node dissection versus limited dissection during radical prostatectomy does not improve biochemical recurrence rates.

Chronic Prostatitis Has Adverse Effects on Sperm

Chronic Prostatitis Has Adverse Effects on Sperm

CBP was associated with a reduction in sperm concentration, sperm vitality, sperm total and progressive motility.

Single Radiation Dose Can Ease Spinal Cord Compression

Single Radiation Dose Can Ease Spinal Cord Compression

New findings establish single-dose radiotherapy as the standard of care for metastatic spinal canal compression, at least for patients with a short life expectancy, researcher says.

Survival Predictors ID'd in mCRPC Patients Treated With Sipuleucel-T

Survival Predictors ID'd in mCRPC Patients Treated With Sipuleucel-T

ECOG status and baseline PSA and PSADT are significantly associated with overall survival.

Low-PSA, High-Grade Prostate Cancer Especially Lethal

Low-PSA, High-Grade Prostate Cancer Especially Lethal

Men with PSA values of 2.5 ng/mL or less and Gleason 8 to 10 prostate tumors are at higher risk of death than other high-risk PCa patients.

Costs Rise After Discovery of Prostate Cancer Metastases

Costs Rise After Discovery of Prostate Cancer Metastases

The researchers found that predicted monthly costs remained relatively stable throughout the observation period among the controls.

First-Line Abiraterone-ADT Combo for Hormone-Naïve PCa Ups Survival

First-Line Abiraterone-ADT Combo for Hormone-Naïve PCa Ups Survival

Addition of abiraterone to androgen deprivation therapy for patients with hormone-naïve advanced prostate cancer may be a new standard of care.

Abiraterone Plus ADT Ups Prostate Cancer Patient Survival

Abiraterone Plus ADT Ups Prostate Cancer Patient Survival

The 3-year overall survival rate among prostate cancer patients starting long-term hormone therapy was 83% vs 76% for men receiving abiraterone plus ADT vs ADT alone.

Diminished QOL Reported More Than 10 Years After PCa Treatment

Diminished QOL Reported More Than 10 Years After PCa Treatment

Urinary incontinence and diminished sexual function were common after a median follow-up of nearly 15 years, study finds.

Salvage RARP Feasible After PCa Focal Therapy Failure

Salvage RARP Feasible After PCa Focal Therapy Failure

Overall complication rates were similar between primary and salvage RARP groups, but there were some notable differences in prognosis.

MRI Accuracy for Prostate Cancer Challenged

MRI Accuracy for Prostate Cancer Challenged

Systematic biopsies always should be performed in conjunction with targeted biopsy in men with suspected clinically significant PCa at mpMRI.

Novel PSA Assay Improves Prostate Cancer Diagnosis

Novel PSA Assay Improves Prostate Cancer Diagnosis

The new test, IsoPSA, measures all PSA isoforms in serum and more accurately discriminates high-grade cancer from benign disease.

Combined Urinary Testing Helps Detect Aggressive PCa, Avoid Biopsy

Combined Urinary Testing Helps Detect Aggressive PCa, Avoid Biopsy

Combining testing of urinary T2:ERG, PCA3 at thresholds that detected aggressive prostate cancer improved specificity from 18% to 39%.

Detection Down for Prostate Cancer, Up for Other Cancers Since ACA

Detection Down for Prostate Cancer, Up for Other Cancers Since ACA

The investigators found that the percentage of patients diagnosed with stage I cancer increased significantly from 2013 to 2014 after the ACA was implemented.

Prostate Cancer Subtypes Differ in ADT Response After Surgery

Prostate Cancer Subtypes Differ in ADT Response After Surgery

Only luminal B prostate cancers were significantly associated with postoperative response to ADT in a subset analysis in retrospective cohorts.

PCa Active Surveillance Safe, Effective for Younger Patients

PCa Active Surveillance Safe, Effective for Younger Patients

A majority of active surveillance patients under age 60 did not progress to definitive prostate cancer treatment.

MRI-Fusion Biopsy Benefits PCa Active Surveillance Patients

MRI-Fusion Biopsy Benefits PCa Active Surveillance Patients

Targeting PI-RADS 4 and 5 lesions for confirmatory biopsy improves detection of clinically significant cancer.

Sipuleucel-T Survival Benefit Greater in Blacks

Sipuleucel-T Survival Benefit Greater in Blacks

Median overall survival was 9.3 months longer for black versus white patients with metastatic castration-resistant prostate cancer.

Fusion Biopsy Ups Detection of Clinically Significant PCa

Fusion Biopsy Ups Detection of Clinically Significant PCa

Fusion biopsy has improved over the last decade and increasingly detects clinically significant prostate cancer, according to data trends from one institution.

Prostate Cancer Distant Metastasis Predicted by APV

Prostate Cancer Distant Metastasis Predicted by APV

Highest quartile of alkaline phosphatase velocity in men who experience biochemical recurrence after radical prostatectomy is associated with 2-fold higher risk.

Non-index Lesions at Biopsy Help Predict Adverse RP Outcomes

Non-index Lesions at Biopsy Help Predict Adverse RP Outcomes

Systematic biopsy parameters identified patients at higher risk of positive surgical margins.

HoLEP Feasible for BPH Patients With Low-risk Prostate Cancer

HoLEP Feasible for BPH Patients With Low-risk Prostate Cancer

The laser procedure was successful for 7 selected patients with enlarged prostates and LUTS harboring low-risk prostate cancer.

New Risk Models May Reduce Unnecessary Prostate Biopsies

New Risk Models May Reduce Unnecessary Prostate Biopsies

The new risk models improve upon PI-RADS version 1.0 and ERPSC risk calculators used for prostate biopsy decisions.

New Nomogram Improves Post-RP Metastasis Predictions

New Nomogram Improves Post-RP Metastasis Predictions

Nomogram based on a cohort of men with high-risk prostate cancer is more accurate than the CAPRA and MSKCC nomograms, researchers report.

Cholesterol Linked to High-Grade Prostate Cancer

Cholesterol Linked to High-Grade Prostate Cancer

Each 10 mg/dL increase in total cholesterol is associated with a significant 23% greater odds of high-grade prostate cancer.

Bone Metastasis at Diagnosis Predicts Early Prostate Cancer Mortality

Bone Metastasis at Diagnosis Predicts Early Prostate Cancer Mortality

Men who present with prostate cancer bone metastasis and no visceral metastases have a median survival time of 37 months, study finds.

Biopsy Timing in Active Surveillance Not Tied to PCa Reclassification

Biopsy Timing in Active Surveillance Not Tied to PCa Reclassification

But PSA density and body mass index are associated with prostate cancer reclassification.

Yoga May Relieve Symptoms of Prostate Cancer Radiation Tx

Yoga May Relieve Symptoms of Prostate Cancer Radiation Tx

Men who attended yoga classes had less fatigue and better sexual and urinary function than those in the comparison group.

PSA Surge With Abiraterone Has No Long-Term Impact on Outcome

PSA Surge With Abiraterone Has No Long-Term Impact on Outcome

Spike in PSA level after starting abiraterone does not affect progression-free or overall survival, study finds.

More Preclinical PCa, Progression Among Black Men

More Preclinical PCa, Progression Among Black Men

Also increased risk of progression to metastatic disease compared with the general population.

Metformin Plus Chemo Does Not Up mCRPC Survival

Metformin Plus Chemo Does Not Up mCRPC Survival

Survival curves showed that metformin use with docetaxel did not improve prostate cancer specific survival or overall survival.

USPSTF Issues Draft PCa Screening Recommendations

USPSTF Issues Draft PCa Screening Recommendations

The US Preventive Services Task Force now suggests decisions about PSA testing should be made on an individual basis for men aged 55 to 69.

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

PSA Doubling Time Predicts Metastasis, Mortality Risks in CRPC

Study identifies PSADT cut-points that can aid in risk stratification of men with non-metastatic castration-resistant prostate cancer.

Prostate Cancer Risk Lower in Black Men With High VDBP

Prostate Cancer Risk Lower in Black Men With High VDBP

Highest vs lowest quartile of vitamin D binding protein associated with 55% lower odds of prostate cancer.

Prostate Cancer Progression Risk in AS Not Linked to Family History

Prostate Cancer Progression Risk in AS Not Linked to Family History

A family history of prostate cancer was not a major determinant of disease progression during active surveillance, according to a systematic review.

Taking Aspirin Regularly May Reduce Death From Cancer

Taking Aspirin Regularly May Reduce Death From Cancer

Regular aspirin use linked to lower risk of cancer mortality, especially colorectal, breast, and prostate cancer.

Earlier vs Later Prostate Cancer Recurrence Characterized

Earlier vs Later Prostate Cancer Recurrence Characterized

Pathologic Gleason scores, positive surgical margin rates, and PSA doubling times differentiate earlier from later biochemical recurrence after radical surgery.

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Lack of Sleep Linked to Prostate Cancer Death in Younger Men

Among men under the age of 65, men who got 3 to 5 hours of sleep per night had a 55% greater risk of dying of prostate cancer than men who got 7 hours of sleep per night.

Predictors of Post-RARP Readmission Identified

Predictors of Post-RARP Readmission Identified

Patients with longer hospital stays and pre-discharge complications were at increased risk of readmission within 30 days of discharge.

Many Men Lack Information on PSA Screening Pros, Cons

Many Men Lack Information on PSA Screening Pros, Cons

In 2014, 33.9% of men reported that their health care providers failed to communicate the benefits and risks of PSA-based screening, an increase from 2012.

Study Supports PCa Screening With MRI vs TRUS-biopsy

Study Supports PCa Screening With MRI vs TRUS-biopsy

Population-based prostate cancer screening with MRI has a significantly better risk/benefit ratio.

Study Finds Low Rate of AS Failure Regardless of PCa Risk

Study Finds Low Rate of AS Failure Regardless of PCa Risk

Select intermediate- and high-risk patients had no greater risks of metastases, AS failure, or interventions over a median of 4 years.

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

Prostate Cancer Active Surveillance Does Not Up Metastasis Risk

Study finds no difference in metastasis-free survival observed after 15 years compared with radiation therapy or radical prostatectomy.

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

Prostate Biopsy May Be Avoidable if MRI Findings Are Negative

In a study, systematic biopsy detected clinically significant prostate cancer in only 3% of men with negative findings on multiparametic MRI.

Adverse Effects of Treatment for Localized PCa Clarified

Adverse Effects of Treatment for Localized PCa Clarified

Findings from 2 new studies could enable more informed patient counseling about choice of therapy.

Nerve-sparing RP May Not Raise Positive Margin Risk

Nerve-sparing RP May Not Raise Positive Margin Risk

Researchers found no evidence of worse cancer outcomes with nerve-sparing surgery.

TRT Does Not Appear to Increase PCa Risk

TRT Does Not Appear to Increase PCa Risk

A population-based study showed no association between total prostate cancer risk and testosterone replacement therapy (TRT).

Bone Metastases Seldom Progress During Radium-223 Therapy

Bone Metastases Seldom Progress During Radium-223 Therapy

At 6 months of treatment, bone imaging showed stable disease in 94% of patients with available data, study finds.

Prostate MRI Quality May Improve With Bowel Prep

Prostate MRI Quality May Improve With Bowel Prep

In multiparametric magnetic resonance imaging, rectal distension have a negative effect on T2-weighted and diffusion-weighted images.

Targeted Biopsy Detects Gleason Score Upgrading in AS

Targeted Biopsy Detects Gleason Score Upgrading in AS

Men with Gleason score 3 + 4 were 4.65 times more likely to have upgrading than men with an initial Gleason score of 3 + 3 at 3 years.

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

PFS Longer With Abiraterone As Second-Line mCRPC Treatment

Clinical or radiologic progression is less likely with abiraterone plus prednisone than cabazitaxel following first-line docetaxel, study finds.

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

PSA, PSAD Less Predictive of Aggressive PCa in Black Men

Study finds that PSA and PSAD indicated prostate cancer above Gleason score 6 for white men only.

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

Researchers Identify mCRPC Drug Sequence Offering the Best Survival

In a retrospective study, patients lived the longest if they received docetaxel followed by cabazitaxel and then abiraterone or enzalutamide.

Urologists Support Targeted Biopsy

Urologists Support Targeted Biopsy

In a survey, 3 in 5 urologists in the United States indicated they perform MRI-US guided biopsy in current practice.

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

5-Year PCa-Specific Mortality Declined With Increased PSA Testing

From 1995 to 2011, prostate cancer deaths fell by 13.0% among Danish patients diagnosed with low-risk disease.

Prostate Cancer Treatment Prolongs Survival

Prostate Cancer Treatment Prolongs Survival

Study compared PCa patients who underwent surgery or radiation treatment with a matched group of non-cancer controls.

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

Higher BMI Lowers Death Risk in Men With Advanced Prostate Cancer

In a study, each 1-unit increment in body mass index was associated with a 16% lower mortality risk.

Black Patients May Be Adversely Affected by Less PSA Screening

Black Patients May Be Adversely Affected by Less PSA Screening

Black patients who met age criteria for PSA screening were 28% more likely to die of their prostate cancer than patients ineligible for screening.

Metastatic Prostate Cancer Death Rates Declining

Metastatic Prostate Cancer Death Rates Declining

Cancer-specific mortality rates dropped from 72.8% in 1995 to 55.8% in 2011, according to a Danish study.

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Prostate Cancer Risk Stratification Enhanced by Novel MRI Protocol

Researchers compared targeted prostate biopsy based on biparametric magnetic resonance imaging with standard 12-core systematic biopsy.

Cancer Mortality Rate Declining in the US

Cancer Mortality Rate Declining in the US

Cancer mortality decreased by 20.1% between 1980 and 2014, from 240.2 to 192.0 deaths per 100 000 population.

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

PCa Salvage Radiation Plus Anti-Androgen Therapy Improves Outcomes

Combined treatment for recurrent prostate cancer after radical prostatectomy results in decreased long-term all-cause and cancer-specific mortality.

Urologists' Use of Observation for PCa Raises Concern

Urologists' Use of Observation for PCa Raises Concern

For individual urologists, the probability of using observation for low-risk disease ranged widely from 5.1% to 71.2%.

Targeted Biopsy Improves Detection of Significant PCa in Black Men

Targeted Biopsy Improves Detection of Significant PCa in Black Men

Targeted biopsy should be considered for grade 4-5 lesions on the Likert scale, researchers say.

Anxiety, Depression May Up Death Risk for Prostate Cancer

Anxiety, Depression May Up Death Risk for Prostate Cancer

Higher death rates found in cancers not related to smoking, carcinoma of the colorectum, prostate, pancreas, oesophagus, and leukemia.

Antidiabetic Drug Use May Cut PCa Risk

Antidiabetic Drug Use May Cut PCa Risk

The results suggest that hyperinsulinemia may be a risk factor for prostate cancer.

Asians With Metastatic Prostate Cancer Have Better Survival

Asians With Metastatic Prostate Cancer Have Better Survival

The median OS differed by race, with superior OS observed among Asian men than among men of other races.

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Multiparametric MRI May Prevent Unnecessary Prostate Biopsies

Using imaging to triage men with elevated PSA might avoid a quarter of unnecessary biopsies, according to a study.

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

Autologous Urethral Sling Does Not Improve Continence After Prostatectomy

No benefit of autologous urethral sling placement at robotic assisted radical prostatectomy on early return of continence at 6 months.

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Prostate Cancer Death Rate Fell in the United States

Prostate Cancer Death Rate Fell in the United States

The investigators found that the cancer mortality rate hit its peak in 1991, before beginning a steady slide of roughly 1.5% per year among both men and women through 2014.

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

No Greater Risk of Bone Metastases With 12-Week Zoledronic Acid

The proportions of skeletal-related events did not differ significantly between the every 4-week dosing group vs the every 12-week dosing group of bone metastases patients.

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate Cancer Risk Lower in Men With Prostate Atrophy

Prostate atrophy in more cores also was associated with lower risks of low- and high-grade disease.

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

In a study, 53.1% of patients had concomitant prostate cancer in radical cystectomy specimens.

New Prostate Cancer Grading System Validated

New Prostate Cancer Grading System Validated

Proposed 5-tiered system found to predict the risk of prostate cancer-specific mortality.

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

Patients on active surveillance with stable disease at the time of initial surveillance prostate biopsy may be appropriate candidates for less intensive surveillance prostate biopsy schedules.

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Lethal Prostate Cancer Linked to BRCA1/2, ATM Mutations

Mutation carrier status was associated with earlier death and among lethal prostate cancer patients (age 67 vs 72 in non-carriers) and shorter survival.

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

Prostate Cancer AS Patients May Benefit From MRI/Fusion Biopsy

In patients undergoing confirmatory biopsy for active surveillance, MRI can increase detection of clinically significant tumors compared with standard systematic biopsy.

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 Methylation of Prostate Biopsies Aids Risk Assessment

PITX2 methylation was increased in tumor-positive biopsies.

Prostate Cancer Active Surveillance Criteria May Need Updating

Prostate Cancer Active Surveillance Criteria May Need Updating

When MRI-US fusion biopsy is added to the standard 12-core biopsy, the number of men eligible for active surveillance decreases, study finds.

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Standard TRUS Prostate Biopsy Needed Despite Negative MRIs

Magnetic resonance imaging of the prostate missed 13% of high-grade cancers that were later found on transrectal ultrasound-guided biopsy.

Radium-223 Reduces Hospital Usage for Skeletal Events

Radium-223 Reduces Hospital Usage for Skeletal Events

CRPC patients treated with radium-223 spent fewer days in the hospital both before and after a skeletal event compared with placebo recipients.

Aggressive Prostate Cancer Diagnoses Declining in US

Aggressive Prostate Cancer Diagnoses Declining in US

Study of men diagnosed with PCa from 2008 to 2013 found declining incidence among whites, blacks, Hispanics, and Asian/Pacific Islanders.

New Prostate Cancer Grading System Predicts Survival After RP

New Prostate Cancer Grading System Predicts Survival After RP

Study shows a significant difference in all-cause and cancer-specific mortality between Gleason score 8 and Gleason score 9-10 disease.

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Complication Risk Due to Obesity Greater With Minimal Invasive RP

Obesity predicts a wider range of complications in PCa patients who undergo laparoscopic or robot-assisted versus open radical prostatectomy.

CTCs May Aid Prostate Cancer Risk Stratification

CTCs May Aid Prostate Cancer Risk Stratification

Analysis of circulating tumor cells may help identify patients at higher risk of biochemical recurrence after treatment.

PCa Cryoablation Achieves Acceptable Outcomes

PCa Cryoablation Achieves Acceptable Outcomes

In a study, the 5-year estimated biochemical failure-free survival rate, based on the Phoenix definition, was 84%.

Infections After Prostate Biopsy Continue to Rise

Infections After Prostate Biopsy Continue to Rise

Patients are at higher risk with the transrectal rather than transperineal approach.

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