ADT Plus Radiation Improves Survival in Metastatic Prostate Cancer
Superior median, 5-year OS for prostate RT plus ADT versus ADT alone in propensity score analyses.
(HealthDay News) -- For men with metastatic prostate cancer (mPCa), overall survival (OS) is improved for those treated with androgen deprivation therapy (ADT) and prostate radiotherapy (RT), compared with ADT alone, according to a study published online in the Journal of Clinical Oncology.
Chad G. Rusthoven, MD, from the University of Colorado School of Medicine in Aurora, and colleagues examined the OS of men with mPCa treated with ADT, with and without prostate RT, using data from the National Cancer Database. A total of 6382 men with mPCa were identified, of whom 8.4% received prostate RT.
At a median follow-up of 5.1 years, the researchers found that the addition of prostate RT to ADT correlated with improved OS on univariate analysis (P < .001) and multivariate analysis adjusted for confounding variables (hazard ratio, 0.624; P < .001). Superior median and 5-year OS were seen for RT plus ADT versus ADT alone in propensity score analysis with matched baseline characteristics (P < .001). Improved OS was seen with prostate RT in all subsets in landmark analyses limited to long-term survivors of at least 1, 3, and 5 years (all P < .05). No significant differences were seen in OS in secondary analyses comparing the survival outcomes for patients treated with a therapeutic dose of RT plus ADT versus prostatectomy plus ADT, although both therapies were superior to ADT alone.
"In this large contemporary analysis, men with mPCa receiving prostate RT and ADT lived substantially longer than men treated with ADT alone," the authors write. "Prospective trials evaluating local therapies for mPCa are warranted."
Several authors disclosed financial ties to the biopharmaceutical industry.
1. Rusthoven CG, Jones BL, Flaig TW, et al. Improved Survival With Prostate Radiation in Addition to Androgen Deprivation Therapy for Men With Newly Diagnosed Metastatic Prostate Cancer. JCO. doi: 10.1200/JCO.2016.67.4788.