Parathyroid Hormone

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

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Serum parathyroid hormone levels significantly increased from 42.2 to 114.8 pmol/L over 12 months in patients who halted the calcimimetic drug.

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

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Pre-operative parathyroid hormone and calcium levels and pruritus are significantly associated with development of severe hypocalemia.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

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Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

Cinacalcet Administration After Hemodialysis Safe, Effective

Cinacalcet Administration After Hemodialysis Safe, Effective

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Control of parathyroid hormone did not differ markedly at 48 and 72 hours after in-center HD compared with 24 hours after daily oral administration of 30 mg cinacalcet.

Parathyroidectomy Reasonable for Refractory SHPT

Parathyroidectomy Reasonable for Refractory SHPT

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The authors of a new review suggest more dialysis patients could benefit from parathyroidectomy.

SHPT May Predict Left Ventricular Diastolic Dysfunction

SHPT May Predict Left Ventricular Diastolic Dysfunction

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iPTH significantly correlated with measures of diastolic dysfunction in patients with non-dialysis chronic kidney disease.

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

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In 2 studies, parathyroid hormone (PTH) values 20 minutes after parathyroidectomy predicted PTH levels for 5 years.

High, Low Values of CKD-MBD Markers Linked With Mortality

High, Low Values of CKD-MBD Markers Linked With Mortality

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In a study, intact parathyroid hormone levels below 60 and above 1500 pg/mL were associated with nearly double the risk of all-cause mortality.

Parathyroidectomy for SHPT Improves Quality of Life

Parathyroidectomy for SHPT Improves Quality of Life

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Patients reported less skin itching, joint pain, and muscle weakness after surgery.

Parathyroidectomy May Improve SHPT Patient Survival

Parathyroidectomy May Improve SHPT Patient Survival

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ESRD patients with SHPT undergoing surgery had a 26% lower risk for all-cause mortality compared with medical management.

Parathyroidectomy Associated With Morbidity, Mortality

Parathyroidectomy Associated With Morbidity, Mortality

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Single-center study reveals a hospitalization rate of 14% following total parathyroidectomy without autotransplantation.

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

Total Parathyroidectomy for Refractory SHPT Improves Bone Metabolism

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Bone mineral density in the lumbar spine and femoral neck increased over time in hemodialysis patients who underwent total parathyroidectomy without autotransplantation.

Residual Kidney Function Predicts Mortality in CKD-MBD

Residual Kidney Function Predicts Mortality in CKD-MBD

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In a study of hemodialysis patients, mortality risk increased along with phosphorus level, particularly among patients with higher residual renal urea clearance.

Off-Target CKD-MBD Biomarkers Prognostic for Adverse Outcomes

Off-Target CKD-MBD Biomarkers Prognostic for Adverse Outcomes

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Dialysis facilities with the least control of PTH, Ca, and P had the greatest risks.

Parathyroidectomy Rarely Achieves KDIGO Targets

Parathyroidectomy Rarely Achieves KDIGO Targets

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Just 6.7% of patients had target levels of calcium, phosphorus, and parathyroid hormone a year after surgery.

Surgical Debridement Improves Survival in Calciphylaxis Patients

Surgical Debridement Improves Survival in Calciphylaxis Patients

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Subtotal parathyroidectomy may lower the death risk of patients with secondary hyperparathyroidism and calciphylaxis.

Parathyroidectomy for SHPT Associated With Reduced Mortality

Parathyroidectomy for SHPT Associated With Reduced Mortality

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The surgery reduced the risk of death from any cause by 37%, meta-analysis shows.

Loop Diuretics May Increase SHPT Risk in Non-Dialysis CKD

Loop Diuretics May Increase SHPT Risk in Non-Dialysis CKD

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SHPT risk was 4 times higher among patients taking furosemide vs hydrochlorothiazide.

Subtotal Parathyroidectomy Safe, Effective, Study Finds

Subtotal Parathyroidectomy Safe, Effective, Study Finds

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Researchers highlighted the benefit of iPTH monitoring.

Parathyroidectomy Rates Stable Despite Changes in Medical Therapy

Parathyroidectomy Rates Stable Despite Changes in Medical Therapy

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The debate continues on how best to use parathyroidectomy to treat severe SHPT.

Subtotal, Total Parathyroidectomy Effective for SHPT

Subtotal, Total Parathyroidectomy Effective for SHPT

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Researchers found insignificant differences between the 2 surgeries in SHPT persistence and recurrence.

Subtotal and Total Parathyroidectomy Similarly Beneficial in SHPT

Subtotal and Total Parathyroidectomy Similarly Beneficial in SHPT

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Intact parathyroid hormone levels fell significantly in all patients who underwent total Ptx with autotransplant and 91.6% of subtotal Ptx patients.

PTH Assay Predicts Incomplete Resection of Parathyroid Gland

PTH Assay Predicts Incomplete Resection of Parathyroid Gland

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In a study, ioPTH decay at 30 minutes post-excision was highly accurate in predicting persistent SHPT.

Parathyroidectomy Cuts Mortality Risk in Patients With Severe SHPT

Parathyroidectomy Cuts Mortality Risk in Patients With Severe SHPT

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Study finds a 20% to 25% lower risk for early death over the long term.

Cardiovascular Mortality After Parathyroidectomy Linked to PTH Levels

Cardiovascular Mortality After Parathyroidectomy Linked to PTH Levels

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Postoperative parathyroid hormone levels of 16.6 pg/mL or higher are associated with a 3-fold increased risk of cardiovascular death.

Phosphorus, Calcium Decreases Linked to Improved HD Patient Survival

Phosphorus, Calcium Decreases Linked to Improved HD Patient Survival

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Lowest relative risk of death observed in patients with serum phosphorus and calcium levels of 4.4 mg/dL and 8.8 mg/dL, respectively.

Non-Dialysis CKD-MBD Care Suboptimal

Non-Dialysis CKD-MBD Care Suboptimal

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One-third of patients who missed clinical targets for phosphorus, calcium and/or parathormone remained untreated.

New Type of PTH Testing May Help Predict HD Patient Death Risk

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A new study suggests that non-oxidized, biologically active PTH testing may help determine mortality risk in hemodialysis patients.

Dialysis Patients May Benefit from New PTH Test

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Novel assay can distinguish between oxidized and nonoxidized forms of parathyroid hormone.

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