Post-RP Radiation Therapy May Raise OAB Risk

De novo OAB — defined as urgency with or without frequency and nocturia — developed in some patients.
De novo OAB — defined as urgency with or without frequency and nocturia — developed in some patients.
Adjuvant or salvage radiotherapy following radical prostatectomy (RP) may increase the likelihood of overactive bladder (OAB), according to study findings published online ahead of print in Urology.

In a study of 875 men who underwent open RP, Gregory W. Hosier, MD, and colleagues at Dalhousie University in Halifax, Nova Scotia, de novo OAB — defined as urgency with or without frequency and nocturia — developed in 19% of patients. Those who underwent subsequent radiotherapy had a nearly 5.6-fold increased relative risk of de novo OAB, after adjusting for age, body mass index, smoking status, cancer stage, and nerve-sparing status, Dr Hosier's team reported.

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