Testosterone Replacement May Delay CKD Progression
Testosterone replacement therapy significantly delays all-cause mortality and progression towards ESRD.
ORLANDO, Fla.—Testosterone replacement therapy (TRT) may delay progression of chronic kidney disease (CKD) and lower the risk of death in men with hypogonadism, new findings presented at the National Kidney Foundation's 2017 Spring Clinical Meetings suggest.
Archana Goel, MD, of the Veterans Administration Medical Center in Kansas City, Missouri, and colleagues analyzed data from a large cohort of veterans diagnosed with low total testosterone (TT). The investigators divided patients into 2 groups: those treated and who had normalization of TT (38,708 men) and those who were not treated (9755 men) and continued to have low TT. The treated and untreated groups had follow-up times of 6.1 and 5.1 years, respectively.
The groups did not differ significantly in the number of days until patients had a 30% or greater increase in serum creatinine or doubling of serum creatinine from baseline, the investigators reported in a poster presentation. The treated group, however, showed a significant delay in the progression of CKD as measured by days to serum creatinine increases of 1.5 or higher and 3.0 mg/dL or higher. TRT delayed the time to end-stage renal disease (ESRD), as defined by a serum creatinine level greater than 6.0 mg/dL) by 284 days and time to death by 328 days. Compared with the untreated men, the treated men had a 24% decreased risk of ESRD and 25% decreased risk of death.
Dr Goel's group concluded that “TRT does not associate with significant disadvantages at earlier stages of CKD, but rather a significant decrease and delay in all-cause mortality and delay in progression toward ESRD.”
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Goel A, Oni O, Wiegmann P, et al. Testosterone replacement therapy (TRT) delays progression of CKD and ESRD. Poster presented at the National Kidney Foundation's 2017 Spring Clinical Meetings in Orlando, Florida. Poster 239.