Lower Phosphorus, Higher Protein Intake Improve Survival
Protein levels found to modify the effect of serum phosphorus with mortality in HD patients.
Higher protein intake and well-controlled serum phosphorus are associated with a greatest survival benefit in maintenance hemodialysis (MHD) patients, researchers reported at the National Kidney Foundation 2014 Spring Clinical Meeting in Las Vegas.
In a cohort study, Kamyar Kalantar-Zadeh, MD, PhD, of the University of California Irvine, and colleagues studied 108,635 MHD patients followed for up to 5 years. The cohort had a mean age of 64 years. The composition of the cohort was 59% diabetic, 45% women, and 33% black.
Compared with patients who had a serum phosphorus level of 7.0 mg/dL or higher and a normalized protein catabolic rate (nPCR)—a surrogate of dietary protein intake—below 0.8 g/kg/day, patients with a serum phosphorus level of at least 3.5 but less than 5.5 mg/dL and an nPCR of at least 1 but less than 1.2 g/kg/day had the greatest survival: a 51% decreased risk of death in a fully adjusted model.
The researchers noted that their results are limited by the lack data on protein binders.