Racial Differences in Mineral Metabolism Identified
ORLANDO, Fla.—Researchers have confirmed findings from previous study showing that racial differences in markers of mineral metabolism in patients with chronic kidney disease, according to a presentation at the National Kidney Foundation's 2013 Spring Clinical Meetings.
Patricia Wahl, MD, and colleagues at the University of Miami School of Medicine studied 1,287 participants in the Chronic Renal Insufficiency Cohort (CRIC) study, including 561 black and 728 non-black subjects. Significantly greater proportions of blacks than non-blacks were female, had a history of diabetes, and were smokers, according to researchers.
Black race was associated with significantly higher parathyroid hormone (PTH) levels compared with non-black race, after adjusting for age, gender, diabetes and smoking status, dietary intake, 25-hydroxyvitamin D (25D) level, blood pressure, body mass index, estimated glomerular filtration rate, and serum albumin, calcium, and phosphate levels. In similar adjusted models, black race also was associated with significantly higher serum calcium and lower 25D levels and significantly lower levels of fibroblast growth factor 23.