Uric Acid Stones May be Linked to Diabetes

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Patients with diabetes mellitus are at higher risk for urinary stones.
 
Diabetes mellitus may increase the risk of urinary stones and predispose individuals to the development of uric acid stones, according to Mayo Clinic researchers.

They studied 3,561 nephrolithiasis cases and a like number of age- and sex-matched controls in Olmsted County, Minn. From this group, 260 case-control pairs were randomly selected for a detailed record review. Of the 260 stone-formers, 122 had information available about stone type.
 
In the initial analysis, stone-formers were 22% more likely to have diabetes than non-stone-formers, after adjusting for age, sex, calendar year of diagnosis, hypertension, and obesity, the researchers, led by John C. Lieske, MD, reported in the American Journal of Kidney Diseases (2006;48:897-904).

Hypertension and obesity were significantly associated with stone formation prior to adjustment but not after. There was no significant link between stone formation and diabetes or hypertension after adjusting for confounders, but stone formation risk increased significantly with rising BMI.
 
In addition, of the 122 stone-formers, 10 had uric acid stones and four (40%) had diabetes. By comparison, diabetes was present in only 9% of those with calcium stones and 7% of controls. Uric acid stones occurred in four (29%) of 14 subjects with diabetes compared with six (6%) of 108 subjects without diabetes, according to the investigators.

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