Sildenafil May Decrease BP
Regular use of sildenafil lowers BP in patients with hypertension, according to researchers in the
In a randomized, double-blind, two-way crossover study by David J. Webb, MD, and his colleagues at the
Sildenafil significantly reduced both systolic and diastolic ambulatory 24-hour, daytime, and nighttime BP compared with both baseline and placebo, Dr. Webb's research group reported in Hypertension (2006; 48:622-627). The reduction in average daytime BP in patients receiving sildenafil was 8/6 mm Hg compared with baseline and about 10/6 mm Hg compared with placebo.
Sildenafil significantly reduced clinical BP compared with placebo (change from baseline to 1 hour after drug administration) on study day 16: Systolic BP declined by 5 mm Hg with sildenafil but rose 4 mm Hg with placebo; diastolic BP decreased by 5 mm Hg with sildenafil and increased by 2 mm Hg with placebo.