NSAIDs Linked to Increased Atrial Fibrillation Risk
Among elderly individuals, increased risk for current, recent use compared with never-use.
In elderly adults, current and recent non-steroidal anti-inflammatory drug (NSAID) use is associated with increased risk of atrial fibrillation, according to a study published in BMJ Open.
Bouwe P. Krijthe, from the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues examined the correlation between NSAID use and the risk of atrial fibrillation. Data were included for 8,423 elderly individuals (mean age, 68.5 years; 58 percent women) without atrial fibrillation at baseline, from the follow-up Rotterdam Study.
During a mean follow-up of 12.9 years, the researchers found that 857 participants developed atrial fibrillation. The risk of atrial fibrillation was increased with current NSAID use versus never-use (hazard ratio, 1.76). After adjustment for age, sex, and multiple potential confounders, the risk of atrial fibrillation was also increased for recent NSAID use (within 30 days of NSAID discontinuation) compared with never-use (hazard ratio, 1.84).
"In this study, use of NSAIDs was associated with an increased risk of atrial fibrillation," the authors write. "Further studies are needed to investigate the underlying mechanisms behind this association."
One author disclosed financial ties to the nutrition and nutritional supplement industries.