Machine Perfusion Better for Allografts
Preserving renal allografts using machine perfusion (MP) rather than cold storage is associated with significantly better graft survival and reduced likelihood of returning to hemodialysis, according to researchers.
A team at
The five-year graft survival was 68.2% for the MP-stored kidneys compared with 54.2% for the cold storage kidneys, the authors reported in the American Journal of Transplantation (2007;7:1942-1947). Five years after transplantation, recipients of cold storage kidneys returned to hemodialysis almost twice as frequently as recipients of MP-stored kidneys (36% vs. 20%).
After controlling for the influence of short-term graft performance (acute rejection), MP significant decreased the likelihood of return to hemodialysis by 53%.
Five years following transplantation, the proportion of patients with a creatinine level below 2 mg/dL was 63% in the MP group compared with 45.7% in the CS group. Mortality was not significantly different between the MP and CS groups (16.5% and 17%, respectively) at five years.
The incidence of delayed graft function was similar for the MP and CS kidneys despite longer preservation times for the MP kidneys, the investigators noted.