Low Vitamin D Heralds Worse Outcomes
Deficiency in CKD patients linked to greater mortality and cardiovascular problems, data suggest.
In one study, Pietro Ravani, MD, of the Istituti Ospitalieri in
After a mean follow-up of 46.5 months, 78 patients died (66% from cardiovascular causes). Twenty-one of these patients previously had started dialysis. Higher levels of 25-hydroxyvitamin D at baseline predicted both longer renal (dialysis free) and patient survival. Each 1 ng/mL increment in 25-hydroxyvitamin D was associated with a 4% reduced death risk,
Dr. Ravani's team reported. Levels of 25-hydroxyvitamin D higher than the median value (18 ng/mL) in an adjusted model were associated with a significant 44% lower risk for starting dialysis and for death compared with lower values.
Link to cardiovascular risk factors
Researchers presented findings, at the conference, of two Portuguese studies of hemodialysis patients showing that 25-hydroxyvitamin D deficiency (levels below 15 ng/mL) is independently associated with in-creased pulse pressure, increased left ventricular mass index, and vascular calcification, all of which are cardiovascular risk factors.
Additionally, researchers who studied peritoneal dialysis patients in