Once Pregnant, Living Kidney Donors More Likely to Have Hypertension
the Renal and Urology News take:
Living kidney donors are more likely to be diagnosed with high blood pressure or preemclampsia once pregnant compared to non-donors, according to a recent study published in The New England Journal of Medicine.
The study, however, stresses the distinction that while living kidney donors are more likely, it found no difference between the two groups in maternal and fetal outcomes. None of the donors experienced stillbirth or neonatal death, and most of the women had uncomplicated pregnancies after donation.
Krista Lentine, MD, MSc, and fellow researchers of the Living Kidney Foundation of Canada performed the retrospective cohort study, comparing 85 pregnant living donors with 510 pregnant non-donors. Their donations occurred between 1992 and 2009 across five different transplant centers in Ontario.
They found that there was approximately a 1 in 10 chance of developing gestational hypertension or preeclampsia in pregnancy after donation, compared to 1 in 20 in non-donors.
“Our findings are highly relevant to clinical practices guidelines and informed consent policies, which to date have no addressed potential impacts of kidney donation on subsequent pregnancies,” Dr. Lentine said.
“These findings can be shared with potential donors and recipients as part of the informed consent process to proceed with transplantation,” said co-author Amit Garg, MD, PhD. “This information can also be used to guide the care of pregnant donors.”
Living kidney donors are more likely to be diagnosed with high blood pressure or preemclampsia once pregnant.
Nearly 30,000 people become living kidney donors worldwide each year, and many are young women. Researchers at the Institute for Clinical Evaluative Sciences (ICES), Lawson Health Research Institute and Western University set out to determine if being a living donor has any effect on future pregnancies.
The study, published in the New England Journal of Medicine, found living kidney donors were more likely to be diagnosed with gestational hypertension (high blood pressure) or preeclampsia than non-donors.
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