Kidney Stone Risk is Linked to Fructose
Consumption of fructose-rich foods may increase a person's risk of kidney stones.
High levels of fructose intake are independently associated with an increased risk of kidney stones, according to researchers.
The finding, by Eric N. Taylor, MD, and Gary C. Curhan, MD, of the Channing Laboratory in
Compared with lowest quintile of total fructose intake, the highest quintile was associated with a 37% in-creased risk of a new kidney stone in the older women, a 35% increased risk in the younger women, and a 27% increased in the men, after adjusting for potential confounders, the researchers reported in Kidney International (2008;73:207-212).
NHS I enrolled women aged 30-55 years in 1976. NHS II enrolled women aged 25-42 years in 1989. The HPFS enrolled male health professionals aged 40-75 years in 1986.
“Clinicians caring for patients with stone disease should make sure that individuals who decrease their intake of protein or fat are aware that they should not subsequently increase their consumption of fructose-rich foods,” the authors wrote.
Drs. Taylor and Curhan observed that fructose consumption has increased substantially in the past few decades. “This intake,” they noted, “may increase the urinary excretion of calcium, oxalate, uric acid, and other factors associated with kidney stone risk.”