Key OAB Symptoms Not Related to Detrusor Overactivity

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The cardinal symptoms of overactive bladder (OAB)—urinary urgency, frequency, and urge urinary incontinence—are not significantly associated with detrusor overactivity after adjustment for other risk factors, a study found.

In fact, the only factors found to be independently and significantly associated with detrusor overactivity were patient age (50 years and older) and nocturia, investigators reported at the International Continence Society annual meeting in Rotterdam, the Netherlands. Sarit Aschkenazi, MD, and her colleagues at the Evanston Northwestern University Feinberg School of Medicine in Chicago analyzed data on 492 women who attended a urogynecologic referral center. Of these, 383 patients had urodynamically proven detrusor overactivity. The patients had a median age of 60 years and a median parity of 2. Women with nocturia (define as two or more episodes of urination per night) were 56% more likely to have detrusor overactivity compared with women without nocturia (fewer than two episodes per night), the investigators found. Women aged 50 years and older were 2.4 times as likely as younger women to have detrusor overactivity. The new findings suggest that nocturia should be considered an indicator of detrusor overactivity and perhaps given greater weight in the definition of OAB syndrome, Dr. Aschkenazi said.
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