High Levels of Uric Acid Linked to CKD Death Risk
Magdalena Madero, MD
They studied 839 participants in the Modification of Diet in Renal Disease study who had uric acid measurements obtained. The subjects had CKD stages 3 and 4. The investigators, led by Magdalena
Each 1 mg/dL increase in uric acid was associated with a 17% increase in all-cause mortality and 16% increase in CVD mortality. The patients had a mean age of 52 years; 85% of them were white and 61% were male.
Their mean glomerular filtration rate was 33 mL/min per 1.73 m2 and mean uric acid concentration was 7.63 mg/dL. During a 10-year follow-up, 208 subjects (25%) died from any cause and 127 (15%) died from CVD.
Dr. Madero conducted the study while a fellow at