Gadolinium Peril Confirmed
Scottish researchers have confirmed an association between gadolinium-based contrast agent use and development of nephrogenic systemic fibrosis (NSF) in patients with renal failure undergoing renal replacement therapy (RRT), according to a report in Radiology (2007; published online ahead of print).
The findings come from a retrospective study of 1,826 patients who underwent RRT for chronic renal failure (stage 5 CKD) between January 1, 2000 and July 1, 2006 at two
The authors noted that many centers worldwide have accepted the link between gadolinium-based contrast agents and NSF and have changed practice prior to fulfillment of the Koch postulates of causation.
“As patient care is paramount,” the investigators wrote, “this is a reasonable course of action. If there is no alternative to the use of gadodiamide, the lowest diagnostic dose should be used and prompt dialysis after imaging may facilitate removal of gadodiamide.”
On the basis of their findings and other studies, the authors concluded that gadodiamide no longer should be considered as without risk for use in patients with advanced renal failure who are undergoing RRT.