Antibiotic May Ease Adverse Effects of BCG
Prophylaxis with ofloxacin decreases the incidence of moderate-to-severe adverse effects from bacillus Calmette-Guérin (BCG) intravesical therapy in patients with superficial bladder cancer, French researchers reported. Ofloxacin is a fluoroquinolone with tuberculostatic properties.
Marc Colombel, MD, of Hôpital Edouard Herriot in
Ofloxacin recipients experienced an 18.5% decrease in class II or higher moderate and severe adverse events between instillations 4 and 6, the investigators reported in The Journal of Urology (2006;176:935-939). Ofloxacin also significantly lowered the percentage of Class III adverse events between instillations 1 and 9.