Contrast-Induced Acute Kidney Injury Predicts Poor Outcomes

Condition significantly increases the risk of cardiovascular events and death.
Condition significantly increases the risk of cardiovascular events and death.

Contrast-induced acute kidney injury (AKI) after primary percutaneous coronary intervention (PCI) is associated with poor short- and long-term outcomes, according to study findings published online ahead of print in the European Heart Journal.

The study, by Amar Narula, MD, of New York University Langone Medical Center, and colleagues, included 2,968 patients who underwent PCI. AKI developed in 479 (16.1%). Compared with patients who did not experience AKI, those who did had significantly higher rates of net adverse clinical events (NACE), a combination of major bleeding or a composite of major adverse cardiac events (MACE), which included death, reinfarction, target vessel revascularization for ischemia, or stroke) at 30 days (22.0% vs. 9.3%) and 3 years (40.3% vs. 24.6%).

Additionally, AKI sufferers had higher mortality rates at 30 days and 3 years (8.0% vs. 0.9% and 16.2% vs. 4.5%, respectively). On multivariate analysis, AKI was associated with a 53% increased risk of NACE, a 56% increased risk of MACE, and an 80% increased risk of death at 3 years.

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