Stroke Risk Increases as GFR Declines
Stroke risk increases linearly with decreasing GFR rate and increasing albuminuria, according to a review and meta-analysis.
Stroke risk increases linearly with decreasing glomerular filtration rate (GFR) and increasing albuminuria, according to a systematic review and meta-analysis published online ahead of print in Nephrology Dialysis Transplantation.
Stroke risk increased by 7% with each 10 mL/min/1.73 m2 decrease in GFR and by 10% with each 25 mg/ mmol increase in albumin-creatinine ratio, researchers led by Philip Masson, MD, of the University of Sydney in Australia, reported. Results did not differ by stroke subtype, sex, and varying prevalence of cardiovascular risk factors.
The systemic review and meta-analysis included 63 cohort studies with a total of 2,085,225 participants and 20 randomized clinical trials with a total of 168,516 participants.