Acute Kidney Injury

Severe Vitamin D Deficiency Raises Death Risk in Hemodialysis Patients

February 02, 2012

Hemodialysis (HD) patients with severe vitamin D deficiency are more than twice as likely to die from any cause compared with those who have sufficient levels of the vitamin, according to a German study.
 

Immediate Post-Operative Creatinine Values Improve AKI Prediction

November 01, 2011

Measuring serum creatinine within six hours after cardiac surgery may improve clinicians' ability to predict development of acute kidney injury (AKI), researchers found.
 

Medication Cleared for Atypical Hemolytic Uremic Syndrome

September 26, 2011

The FDA has approved eculizumab for the treatment of atypical hemolytic uremic syndrome (aHUS) in both children and adults, a potentially life-threatening condition.
 

Acute Renal Failure

Acute Renal Failure Secondary to Bilateral Ureteral Obstruction

, September 12, 2011

Editor's Note: "On the Forefront" is a new column dedicated to showing how urologists and nephrologists are collaborating on cases to improve patient care.
 

German Sprouts Blamed for E. coli Illness Outbreak

June 13, 2011

Tainted raw bean and seed sprouts grown in Germany spread the strain of Escherichia coli that caused an outbreak of enterohemorrhagic illness and hemolytic uremic syndrome (HUS) there and in other European countries, investigators concluded.
 

Probe into German E. coli Illness Outbreak Continues

June 08, 2011

Investigators continue to look for the source of a strain of Escherichia coli responsible for a severe outbreak of hemolytic uremic syndrome (HUS) and bloody diarrhea primarily centered in Germany but which has sickened individuals in other European countries.
 

Anemia

Correcting Anemia Reduces Odds of Renal Transplant Failure

December 29, 2011

Complete correction of anemia (hemoglobin, 13 g/dL or higher) in kidney transplant recipients slows progression to chronic allograft nephropathy, a study found.
 

FDA Committee Favors Peginesatide

December 15, 2011

The FDA's Oncologic Drugs Advisory Committee, in a 15 to 1 vote, has agreed that peginesatide demonstrates a favorable benefit/risk profile for use in treatment of dialysis patients with anemia resulting from chronic kidney disease (CKD).
 

Novel Therapy for CKD Anemia Advances

November 16, 2011

PHILADELPHIA—A novel treatment for chronic kidney disease (CKD) patients with anemia is showing positive results following a Phase 1/2 clinical trial, according to findings reported at Kidney Week 2011.
 

Chronic Kidney Disease

Exercise Enhances Body Composition, Nutritional Status in Dialysis Patients

February 01, 2012

Research has shown that individuals who exercise have lower risk for chronic diseases than individuals who do not exercise.
 

CKD Incidence Higher in African Americans Than Whites

February 01, 2012

Researchers who analyzed 20-year follow-up data from a prospective study found that African Americans have a higher incidence of chronic kidney disease (CKD) than whites in part because of albuminuria.
 

Renal Function Decline Often Precedes Macroalbuminuria in Type 2 Diabetes

January 31, 2012

Decreases in glomerular filtration rate (GFR) frequently occur before the onset of macroalbuminuria in patients with type 2 diabetes, according to a study. A GFR decline that predicts development of end-stage renal disease (ESRD), however, strongly depends on progression to macroalbuminuria.
 

Contrast Nephropathy

Hyponatremia May Predict Contrast-Induced Nephropathy

July 05, 2011

PRAGUE—Transient hyponatremia may precede development of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography, according to investigators.
 

Drug Offers No CIN Protection

January 11, 2011

CHICAGO—Brazilian researchers report that acetylcysteine should no longer be used to prevent contrast-induced nephropathy (CIN) in patients undergoing coronary and vascular angiography.
 

CIN Prevention Strategies Similarly Effective

June 18, 2010

Researchers find no difference between saline and sodium bicarbonate.
 

Cardiovascular Disease

Newer Antihypertensive Agents May Be No Better than Diuretics

January 20, 2012

Calcium channel blockers (CCBs) and ACE inhibitors may be no better than diuretics at preventing cardiovascular deaths in patients with hypertension, according to a follow-up study of patients in a seminal antihypertensive trial. In addition, CCBs and ACE inhibitors may increase cardiovascular risks.
 

No Benefit To Adding Niacin to Statin Rx

December 01, 2011

Adding niacin to statin therapy offers no incremental clinical benefit to patients with atherosclerotic cardiovascular disease and LDL cholesterol levels below 70 mg/dL, according to study findings published in the New England Journal of Medicine (online ahead of print).
 

Telephone Intervention Can Help Obese Patients Lose Weight

November 16, 2011

ORLANDO—A weight loss program delivered by telephone can be just as effective in obese patients with at least one cardiovascular risk factor as a weight loss program delivered with in-person support, researchers reported at the American Heart Association Scientific Sessions 2011.
 

Diabetes

Renal Function Decline Often Precedes Macroalbuminuria in Type 2 Diabetes

January 31, 2012

Decreases in glomerular filtration rate (GFR) frequently occur before the onset of macroalbuminuria in patients with type 2 diabetes, according to a study. A GFR decline that predicts development of end-stage renal disease (ESRD), however, strongly depends on progression to macroalbuminuria.
 

Diabetes May Hike Urinary Stone Risk

January 05, 2012

Diabetes mellitus independently predicts an increased risk of urinary tract calculi (UTC), according to a population-based cohort study conducted in Taiwan.
 

Lab Tests Tip Off Employees to CKD, Other Conditions

December 16, 2011

Laboratory tests performed as part of employer-sponsored health risk assessments (HRA) revealed evidence that "newly identified" at least one of three common medical conditions in more than one third of adults, a study found.
 

Diabetic Nephropathy

ESRD More Likely than Death for Patients with Diabetic Nephropathy

December 07, 2011

Patients with type 2 diabetic nephropathy are more likely to progress to end-stage renal disease (ESRD) than die, according to investigators.
 

Podocytes May Need Insulin to Maintain Kidney Function

November 15, 2010

Podocytes demonstrate a strong reliance on insulin to function properly, according to a study published in Cell Metabolism (2010;12:329-340).
 

UACR Varies by Season in Diabetic Nephropathy

November 15, 2010

Researchers have found a seasonal variation in urinary albumin-to-creatinine ratio (UACR) in Japanese patients with type 2 diabetes and early nephropathy, with the highest values in winter and the lowest in summer.
 

Focal Segmental Glomerulosclerosis

Steroids May Harm Athletes' Kidneys

March 02, 2010

Serious renal damage is a possible consequence of long-term abuse of anabolic steroids, data show .
 

Mycophenolate Mofetil Works As Well As Standard Therapy

July 22, 2008

Six months of mycophenolate mofetil (MMF) treatment is as effective in the short term as conventional therapy for primary treatment of membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS), a pilot study in India found.
 

MMF Similar to Conventional Therapies for MN, FSGS

January 01, 2008

A six-month course of treatment with mycophenolate mofetil (MMF) is as effective as conventional therapies for treating membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS), according to a pilot study conducted in India.
 

Hemodialysis

Severe Vitamin D Deficiency Raises Death Risk in Hemodialysis Patients

February 02, 2012

Hemodialysis (HD) patients with severe vitamin D deficiency are more than twice as likely to die from any cause compared with those who have sufficient levels of the vitamin, according to a German study.
 

Let Patients Sleep During Rounds

February 01, 2012

How often do you face with the unpleasant task of waking a sleeping patient during your busy rounds? It happens frequently to many clinicians during their inpatient rounds in the hospital.
 

Antibiotic Lock Reduces Catheter-Related Problems

January 30, 2012

An antibiotic catheter lock containing gentamicin in sodium citrate can decrease the incidence of catheter-related bloodstream infections in patients on maintenance hemodialysis (MHD).
 

BP Drugs May Differ in Cardiovascular Benefits

January 27, 2012

ACE inhibitors and angiotensin receptor blockers (ARBs) confer different cardiovascular benefits in hemodialysis (HD) patients, researchers found.
 

Persistently Low iPTH Not Good for Hemodialysis Patients

January 10, 2012

Persistently low levels of intact parathyroid hormone (iPTH) are independently associated with progression of aortic arch calcification (AAC) and death among incident hemodialysis (HD) patients, according to a new study.
 

Hyperphosphatemia

Novel Tool May Help Dialysis Patients with Phosphorus Control

April 30, 2011

LAS VEGAS—A novel interactive Web-based phosphorus education tool may help to improve phosphorus control in dialysis patients, according to a report at the National Kidney Foundation's Spring Clinical Meetings.
 

Hyperphosphatemia and Anemia Risk Factors in Diabetic Nephropathy Patients

April 30, 2011

LAS VEGAS—Albumunuria, proteinuria, lower estimated glomerular filtration rate (eGFR) in patients with diabetic nephropathy are significantly associated with hyperphosphatemia and anemia, researchers reported at the National Kidney Foundation's Spring Clinical Meetings.
 

Study Finds No Link Between FGF-23 and Dietary Phosphorus

April 29, 2011

LAS VEGAS—Fibroblast growth factor 23 (FGF-23) is not significantly associated with dietary phosphorus or urinary phosphorus excretion, researchers reported at the National Kidney Foundation's Spring Clinical Meetings.
 

Hypertension

Newer Antihypertensive Agents May Be No Better than Diuretics

January 20, 2012

Calcium channel blockers (CCBs) and ACE inhibitors may be no better than diuretics at preventing cardiovascular deaths in patients with hypertension, according to a follow-up study of patients in a seminal antihypertensive trial. In addition, CCBs and ACE inhibitors may increase cardiovascular risks.
 

Vitamin D Has No Blood Pressure Effect in Postmenopausal Women

December 06, 2011

Serum levels of 25-hydroxyvitamin D (25(OH)D) are not related to changes in blood pressure (BP) in postmenopausal women, according to researchers.
 

Supplemental Vitamin D Helps Black Hypertensives

November 22, 2011

ORLANDO—Vitamin D supplementation may reduce blood pressure (BP) in African-American patients with hypertension in a dose-dependent manner, regardless of the intensity of antihypertensive treatment, researchers announced at the American Heart Association Scientific Sessions 2011.
 

Hyperuricemia

Renal Disease, Diabetes Linked to Uric Acid

November 08, 2011

CHICAGO—Uncontrolled serum uric acid in patients with gout is associated with an increased risk of developing kidney disease and diabetes, according to the findings of two studies presented at the American College of Rheumatology annual meeting.
 

High Uric Acid Lowers Death Risk in Hemodialysis Patients

October 29, 2011

High uric acid concentrations are associated with lower all-cause and cardiovascular mortality among hemodialysis (HD) patients, according to an international study.
 

High Uric Acid Predicts Albuminuria

May 19, 2011

VANCOUVER, B.C.--Elevated serum uric acid levels strongly predict development of albuminuria in patients with chronic kidney disease (CKD), according to researchers in Romania.
 

Kidney Cancer

Kidney Cancer Tumor Size, Preoperative eGFR Linked

January 30, 2012

Tumor diameter and decreased preoperative estimated glomerular filtration rate (eGFR) are independently correlated in patients undergoing surgery for renal cell carcinoma (RCC), researchers concluded.
 

Adrenalectomy Rates Remain High in Radical Nephrectomy

January 30, 2012

During a recent 10-year period, the rate of ipsilateral adrenalectomy at the time of radical nephrectomy decreased slightly, a study found.
 

Kidney Cancer Tied to Red Meat Intake

January 27, 2012

Greater intake of red meat may increase the risk of renal cell carcinoma (RCC).
 

Kidney Stones

New Stone Risk Found in VUR Patients

February 01, 2012

Children with vesicoureteral reflux have a higher incidence of hypercalciuria, hyperuricosuria.
 

Diabetes May Hike Urinary Stone Risk

January 05, 2012

Diabetes mellitus independently predicts an increased risk of urinary tract calculi (UTC), according to a population-based cohort study conducted in Taiwan.
 

Antibiotics Could Increase Kidney Stone Risk

November 17, 2011

Antibiotics can decrease colonization of a common intestinal bacterium that metabolizes oxalate, perhaps rendering patients more susceptible to the formation of calcium oxalate kidney stones, according to researchers.
 

Lupus Nephritis

Rituximab Ineffective as Lupus Nephritis Add-On Therapy

January 18, 2012

Adding rituximab to mycophenolate mofetil and corticosteroids does not improve outcomes in patients with lupus nephritis (LN), according to a study.
 

MMF Found Superior for Lupus Nephritis

November 28, 2011

Mycophenolate mofetil (MMF) is more effective than azathioprine as maintenance therapy for patients with active lupus nephritis (LN) who responded to induction therapy, researchers reported.
 

Abatacept May Benefit Some Lupus Nephritis Patients

November 14, 2011

CHICAGO—Adding abatacept to mycophenolate mofetil (MMF) and steroids does not significantly improve the time to complete renal response in patients with lupus nephritis (LN), according to the findings of a 12-month study presented at the 2011 American College of Rheumatology annual meeting.
 

Secondary Hyperparathyroidism

Cinacalcet May Reduce ESA Use

February 23, 2011

PHOENIX—Cinacalcet hydrochloride (CH) treatment in dialysis patients with secondary hyperparathyroidism may improve responsiveness to an erythropoiesis-stimulating agent (ESA) by reducing systemic inflammation, resulting in decreased ESA requirements, new data suggest.
 

Post-Transplant Cinacalcet May Be An Option

November 02, 2010

Cinacalcet may be useful for treating hyperparathyroidism after renal transplantation, new findings suggest.
 

Mineral Metabolism Unaffected by Ergocalciferol

June 18, 2010

Weekly (50,000 units) and monthly doses (50,000 units) of ergocalciferol treatment does not significantly impact markers of mineral metabolism (MM) in chronic hemodialysis (HD) patients, a study suggests.
 

Transplantation

African-American Kidneys May Worsen Transplant Outcomes

February 01, 2012

Recipients of kidneys from African Americans (AA) are at increased risk of all-cause and cardiovascular mortality compared with patients who receive kidneys from non-AA donors.
 

Correcting Anemia Can Protect Renal Allografts

January 31, 2012

Targeting hemoglobin (Hb) values of 13 g/dL or higher reduces progression of chronic allograft nephropathy in kidney-transplant recipients, a prospective study suggests.
 

Risk Factors for Transplant-Related Urinary Complications Characterized

January 26, 2012

MIAMI BEACH, Fla.—A review of 635 kidney transplants performed at the University of Florida, Gainesville, has confirmed that transplanted kidneys with more than one renal artery put recipients at increased risk for urinary complications.
 
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