Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.
Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.

(HealthDay News) -- For adults undergoing surgery, 8 preoperative variables, including low preoperative mean arterial blood pressure, are associated with postoperative kidney function, according to a study published online in Anaesthesia.

Samir M. Kendale, MD, from the New York University Langone Medical Center in New York City, and colleagues examined the correlation of preoperative variables with kidney function in 41,523 adults after scheduled surgery in a large academic hospital.

The researchers identified 8 variables that were independently linked to a reduction in postoperative estimated glomerular filtration rate (eGFR). These included preoperative renal function, age, American Society of Anesthesiologists physical status, cardiac failure, anemia, cancer, type of surgery, and the lowest quartile of preoperative mean arterial blood pressure (<71 mm Hg). For patients with a preoperative mean arterial pressure <71 mm Hg, the eGFR decreased by a mean of 2.7 ml/min/1.73 m² (P = 0.047). Correlations were seen for the same variables and male sex with postoperative acute kidney injury. For patients with a preoperative mean arterial blood pressure <71 mm Hg, the odds ratio for acute postoperative kidney injury was 1.9 (P = 0.005).

"In summary, we found that a number of preoperative variables, including low preoperative mean arterial pressures, were associated with increases in postoperative eGFR and acute kidney injury," the authors write.

Reference

1. Kendale SM, Lapis PN, Melhem SM, Blitz JD. The association between pre-operative variables, including blood pressure, and postoperative kidney function. Anaesthesia. doi: 10.1111/anae.13632.

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