Nephrology Cover Articles

Glomerular Disease Differs Globally

Glomerular Disease Differs Globally

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International survey finds geographic variation in the subtype frequencies in biopsied patients.

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

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Myocardial infarction patients who underwent percutaneous coronary intervention had an AKI rate similar to those who did not have the procedure.

Guidelines for CKD Mineral and Bone Disorder Updated

Guidelines for CKD Mineral and Bone Disorder Updated

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Among other changes, the new KDIGO guidelines highlight the potential dangers of hypercalcemia.

Higher Uric Acid Levels Up Nephrolithiasis Risk

Higher Uric Acid Levels Up Nephrolithiasis Risk

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Nephrolithiasis developed in 18,777 healthy men during 1,184,654 person-years of follow-up.

Obesity Ups Diabetes Risk Among Living Kidney Donors

Obesity Ups Diabetes Risk Among Living Kidney Donors

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The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.

Voclosporin Shows Promise as Lupus Nephritis Treatment

Voclosporin Shows Promise as Lupus Nephritis Treatment

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In a phase 2b trial, around half of patients taking the novel calcineurin inhibitor at a dose of 23.7 mg twice daily achieved complete remission at 48 weeks.

Topically Applied Drug May Improve Hemodialysis Fistula Survival

Topically Applied Drug May Improve Hemodialysis Fistula Survival

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In a study, vonapanitase did not improve primary patency compared with placebo, but did improve secondary patency and fistula use for hemodialysis.

ESRD Renal Recovery Uptick Reported

ESRD Renal Recovery Uptick Reported

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Use of bioimpedance spectroscopy to assess volume depletion could be a factor, researchers say.

Record Number of Transplants in 2016 Reported

Record Number of Transplants in 2016 Reported

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From 2015 to 2016, the number of organ transplants rose from 30,969 to 33,595; the number of kidney transplants increased from 17,878 to 19,061.

Copeptin Predicts IgA Nephropathy Outcomes

Copeptin Predicts IgA Nephropathy Outcomes

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Copeptin, a surrogate marker for arginine vasopressin (AVP), showed prognostic value of established risk markers.

Frequent Hemodialysis Improves Health-Related QoL

Frequent Hemodialysis Improves Health-Related QoL

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Patients feel better and recovery times are shorter with 6 hemodialysis sessions per week rather than 3, researchers report.

Office-Based Renal Mass Biopsy Safe

Office-Based Renal Mass Biopsy Safe

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In a study, only 3 of 108 patients experienced complications, all of which were minor and required no hospitalization or further intervention.

Novel Drug Shows Promise for FSGS

Novel Drug Shows Promise for FSGS

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Sparsentan could become the first FDA-approved medication for the focal segmental glomerularsclerosis.

Calciphylaxis Risk Higher in Peritoneal Dialysis Patients

Calciphylaxis Risk Higher in Peritoneal Dialysis Patients

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Their risk of the rare but life-threatening condition is twice as high as in hemodialysis patients.

Incremental Hemodialysis Does Not Compromise Survival

Incremental Hemodialysis Does Not Compromise Survival

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Mortality risk is similar whether starting treatment with 1 or 2 sessions per week or with the conventional 3 sessions per week.

Secondary Hyperparathyroidism Risk Higher With Furosemide Use

Secondary Hyperparathyroidism Risk Higher With Furosemide Use

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Study reveals 6-fold higher risk of SHPT in patients on furosemide vs hydrochlorothiazide.

Intensive BP Control in CKD Improves Survival

Intensive BP Control in CKD Improves Survival

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Black CKD patients with strict blood pressure control had a 19% lower risk of premature death.

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

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Average weekly doses greater than 70 µg/week was associated with a 77% increased risk of cancer compared with no ESA exposure.

Higher Red Meat Intake Raises Kidney Failure Risk

Higher Red Meat Intake Raises Kidney Failure Risk

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Highest vs lowest quartile of intake is associated with a 40% increased risk.

Muscle Density Predicts Death Risk in Patients Waiting for a Kidney

Muscle Density Predicts Death Risk in Patients Waiting for a Kidney

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Each Hounsfield unit increase on CT is associated with a 7% decreased risk of death among waitlisted kidney transplant candidates.

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

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Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.

Study: Diabetic Nephropathy Underdiagnosed

Study: Diabetic Nephropathy Underdiagnosed

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Diabetic nephropathy lesions may develop prior to the onset of clinical findings.

Statins Protect Against Kidney Stones

Statins Protect Against Kidney Stones

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Use of the lipid-lowering drugs is associated with 43% and 47% decreased odds of new stones in recurrent stone formers and stone naïve patients.

Study Challenges Obesity-Chronic Kidney Disease Link

Study Challenges Obesity-Chronic Kidney Disease Link

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After adjusting for potential confounders and mediators, a large cross-sectional study found no association between obesity and CKD prevalence.

Nephrology Attracting Fewer Doctors

Nephrology Attracting Fewer Doctors

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Fellowship positions go unfilled as the US faces expanding population of kidney disease patients.

Kidneys from Incompatible Live Donors Offer a Survival Advantage

Kidneys from Incompatible Live Donors Offer a Survival Advantage

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Survival rates are lower among patients who receive a deceased-donor kidney or remain on the transplant waiting list.

Peritoneal Dialysis Outpacing Home Hemodialysis

Peritoneal Dialysis Outpacing Home Hemodialysis

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Trend started around the introduction of the Medicare prospective payment system for dialysis care.

Polycystic Kidney Disease Raises Atrial Fibrillation Risk

Polycystic Kidney Disease Raises Atrial Fibrillation Risk

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In a study, the arrhythmia was 31% more likely to occur in PKD patients than non-PKD control patients.

Earlier ESA Initiation May Improve Renal Outcomes

Earlier ESA Initiation May Improve Renal Outcomes

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Study shows benefit of initiating epoetin beta therapy at hemoglobin levels not less than 10 g/dL in non-dialysis CKD patients.

Kidney Damage Linked to Prediabetes

Kidney Damage Linked to Prediabetes

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In a prospective study, prediabetes was an independent risk factor for hyperfiltration and increased albuminuria.

Some Discarded Higher-Risk Kidneys May Be Transplantable

Some Discarded Higher-Risk Kidneys May Be Transplantable

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Just over half of kidneys from deceased ECD/DCD donors are not used, study finds.

Current eGFR Better for ESRD Prediction

Current eGFR Better for ESRD Prediction

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It has a stronger association with future end-stage renal disease risk than past eGFR decline, large study shows.

Plasma Biomarker Promises Earlier Indication of CKD Risk

Plasma Biomarker Promises Earlier Indication of CKD Risk

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High levels of soluble urokinase-type plasminogen activator receptor are associated with an elevated CKD risk in individuals with normal eGFR.

Hyperkalemia Increases Death Risk in Hemodialysis Patients

Hyperkalemia Increases Death Risk in Hemodialysis Patients

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The condition also occurs more frequent on the day after the long interdialytic interval.

Kidney Stone Risk in Men Linked to Vitamin C Intake

Kidney Stone Risk in Men Linked to Vitamin C Intake

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Elevated risk observed with total and supplemental, but not dietary, vitamin C intake.

Higher Phosphorus Ups Anemia Risk

Higher Phosphorus Ups Anemia Risk

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Researchers find link in the non-dialysis population.

Longer Dialysis Session Gap Raises Hospitalization, Death Risk

Longer Dialysis Session Gap Raises Hospitalization, Death Risk

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Fluid overload implicated as an important risk factor for hospital admission.

Rapid Loss of Kidney Function Linked to Obesity

Rapid Loss of Kidney Function Linked to Obesity

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Large study shows the association is more pronounced with increasing age.

Death Risk Lower with Home Hemodialysis than Peritoneal Dialysis

Death Risk Lower with Home Hemodialysis than Peritoneal Dialysis

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Daily home hemodialysis also decreases likelihood of hospitalization and technique failure.

Parathyroidectomy for Severe SHPT Improves Survival

Parathyroidectomy for Severe SHPT Improves Survival

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Hemodialysis patients who undergo the procedure experience decreased risks of all-cause and cardiovascular mortality.

Late Life CKD Possibly Linked to Higher Midlife Blood Pressure

Late Life CKD Possibly Linked to Higher Midlife Blood Pressure

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New findings may offer possible strategies for preventing renal function decline.

High BMI May Predict Increased CKD Progression Risk

High BMI May Predict Increased CKD Progression Risk

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The association is particularly pronounced in younger patients with higher levels of proteinuria.

Race Gap in Kidney Transplant Outcomes Narrows Dramatically

Race Gap in Kidney Transplant Outcomes Narrows Dramatically

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At the end of a 22-year study period, the 1- and 3-year risk of graft loss did not differs significantly between black and white recipients.

Donor Kidneys Usable Despite Acute Kidney Injury

Donor Kidneys Usable Despite Acute Kidney Injury

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Recipients of AKI kidneys have patient and graft survival rates similar to those of recipients of non-AKI kidneys.

Warfarin Found to Raise Calciphylaxis Risk

Warfarin Found to Raise Calciphylaxis Risk

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New findings add to a growing body of evidence supporting the avoidance of vitamin K antagonists in dialysis patients.

Low Magnesium Raises Hemodialysis Patients' Death Risk

Low Magnesium Raises Hemodialysis Patients' Death Risk

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The increased risk is especially pronounced among patients with low serum albumin.

High Fluid Intake Lowers Kidney Stone Risk

High Fluid Intake Lowers Kidney Stone Risk

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Meta-analysis finds a reduction in the risk of incident and recurrent kidney stones.

Study Backs Renal Transplantation in HIV-Infected Patients

Study Backs Renal Transplantation in HIV-Infected Patients

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In the absence of co-infection with hepatitis C virus, their graft and patient survival rates are similar to those of HIV-negative patients.

Mild CKD Linked to Worse Pregnancy Outcomes

Mild CKD Linked to Worse Pregnancy Outcomes

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Researchers found 88% higher odds of negative pregnancy outcomes for women with stage 1 CKD and no classic risk factors.

Interarm BP Differences Predict Cardiovascular Events in CKD Patients

Interarm BP Differences Predict Cardiovascular Events in CKD Patients

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A difference of 10 mm Hg or more in systolic blood pressure was associated with an 80% increased risk.

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