Pharmacological Effects of Alcohol with Medications

PHARMACOLOGICAL EFFECTS OF ALCOHOL WITH MEDICATIONS
Generic Brand Potential Reactions
ALLERGIES/COLD/FLU
brompheniramine Dimetapp Cold & Allergy Drowsiness, dizziness, increased risk for overdose
cetirizine Zyrtec
chlorpheniramine Sudafed Sinus & Allergy
Triaminic Cold & Allergy
Tylenol Allergy Sinus
Tylenol Cold & Flu
desloratadine Clarinex
diphenhydramine Benadryl
fexofenadine Allegra, Allegra‑D
loratadine Alavert
Claritin, Claritin‑D
ANGINA
isosorbide Isordil Rapid heartbeat, sudden changes in blood pressure, dizziness, fainting
nitroglycerin Nitrostat, Nitro‑Bid
ANXIETY/EPILEPSY
alprazolam Xanax Drowsiness, dizziness, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
clonazepam Klonopin
chlordiazepoxide Librium
diazepam Valium
lorazepam Ativan
paroxetine Paxil
clomipramine Anafranil Drowsiness, dizziness, increased risk for overdose, increased feelings of depression or hopelessness in adolescents (suicide)
fluvoxamine Luvox
herbal
preparations
Kava Kava Liver damage, drowsiness
ARTHRITIS
celecoxib Celebrex Ulcers, stomach bleeding, liver problems
diclofenac Voltaren
naproxen Naprosyn
BLOOD CLOT
warfarin Coumadin Occasional drinking may lead to internal bleeding; heavier drinking also may cause bleeding or may have the opposite effect, resulting in possible blood clots, strokes, or heart attacks
COUGH
dextromethorpan Delsym Drowsiness, dizziness, increased risk for overdose
Robitussin Cough & Cold
guaifenesin + codeine
DEPRESSION
amitriptyline Drowsiness, dizziness, increased risk for overdose, increased feelings of depression or hopelessness in adolescents (suicide)
bupropion Wellbutrin
citalopram Celexa
desipramine Norpramin
escitalopram Lexapro
fluoxetine Prozac
nefazodone
paroxetine Paxil
sertraline Zoloft
trazodone
venlafaxine Effexor
herbal
preparations
St. John's Wort
DIABETES
glyburide Abnormally low blood sugar levels, flushing reaction (nausea, vomiting, headache, rapid heartbeat, sudden changes in blood pressure)
metformin Glucophage
ENLARGED PROSTATE
doxazosin Cardura Dizziness, light headedness, fainting
prazosin Minipress
tamsulosin Flomax
terazosin Hytrin
HEARTBURN/GERD
cimetidine Tagamet Rapid heartbeat, sudden changes in blood pressure (metoclopramide), increased alcohol effect
metoclopramide Reglan
nizatidine Axid
ranitidine Zantac
 
Generic Brand Potential Reactions
HYPERLIPOPROTEINEMIA
atorvastatin Lipitor Liver damage (all medications); increased flushing and itching (niacin)
ezetimibe + simvastatin Vytorin
lovastatin
lovastatin + niacin Advicor
niacin Niaspan
pravastatin Pravachol
rosuvastatin Crestor
simvastatin Zocor
HYPERTENSION
benzapril Lotensin Dizziness, fainting, drowsiness, heart problems such arrhythmia
clonidine Catapres
doxazosin Cardura
enalapril Vaseretic
hydrochloro-
thiazide
Capozide
Lopressor HCT
losartan Cozaar
prazosin Minipress
quinapril Accupril
terazosin Hytrin
INFECTION
cycloserine Seromycin Fast heartbeat, sudden changes in blood pressure, stomach pain, upset stomach, vomiting, headache, or flushing or redness of the face; liver damage (isoniazid, ketoconazole)
griseofulvin
isoniazid
ketoconazole Nizoral
metronidazole Flagyl
nitrofurantoin Macrodantin
tinidazole Tindamax
INSOMNIA
diphenhydramine Sominex Drowsiness, sleepiness, dizziness, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
doxylamine Unisom
estazolam
eszopiclone Lunesta
temazepam Restoril
zolpidem Ambien
herbal
preparations
Chamomile, Valerian, Lavender Increased drowsiness
MUSCLE PAIN
carisoprodol Soma Drowsiness, dizziness, increased risk of seizures, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
cyclobenzaprine
NAUSEA
dimenhydrinate Dramamine Drowsiness, dizziness, increased risk for overdose
hydroxyzine
meclizine Antivert
promethazine
PAIN/HEADACHE/MIGRAINE
acetaminophen Tylenol Upset stomach, bleeding, ulcers, rapid heartbeat; liver damage (acetaminophen)
acetaminophen + 
aspirin
Excedrin
ibuprofen Advil
Motrin
naproxen Aleve
butalbital + codeine Fiorinal with Codeine Drowsiness, dizziness, increased risk for overdose, slowed or difficulty breathing, impaired motor control, unusual behavior, memory problems
hydrocodone Vicodin
meperidine Demerol
oxycodone Percocet
SEIZURE
clonazepam Klonopin Drowsiness, dizziness, increased risk of seizures
phenobarbital
phenytoin Dilantin
REFERENCES

Harmful Interactions: Mixing Alcohol with Medicines. NIAAA. Accessed: September 10, 2013. Available at: http://pubs.niaaa.nih.gov/publications/
Medicine/medicine.htm

Not an inclusive list of medications that may interact with alcohol. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Created 9/2013)

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