Hypertension Treatments: Diuretics

HYPERTENSION TREATMENTS: DIURETICS
Generic Brand Strength Form Usual Dose
LOOP DIURETICS
furosemide Lasix 20mg, 40mg+, 80mg tabs Adults: Initially 40mg twice daily. Adding to other antihypertensives: Initially reduce other agent's dose by 50%.
Children: Not recommended.
torsemide 10mg/mL injec-
tion
Adults: 5mg once daily, may increase to 10mg once daily. Give IV dose over a period of 2min.
Children: Not recommended.
Demadex 5mg, 10mg, 20mg, 100mg scored tabs
POTASSIUM SPARING DIURETICS
amiloride 5mg tabs Adults: Administer with kaliuretic and food. Initially 5mg/day; 5−10mg usually adequate. If hypokalemia persists, may increase to 15mg/day and then 20mg/day with careful electrolyte monitoring.
Children: Not recommended.
eplerenone Inspra 25mg, 50mg tabs Adults: Initially 50mg once daily; may increase after 4wks to max 50mg twice daily. Concomitant weak CYP3A4 inhibitors (eg, erythromycin, verapamil, saquinavir, fluconazole): Initially 25mg once daily. Adjust based on serum K+ (see literature).
Children: Not recommended.
spirono-
lactone
Aldactone 25mg, 50mg+, 100mg+ tabs Adults: Initially 50−100mg/day in single or divided doses. Titrate at 2‑wk intervals.
Children: Not recommended.
POTASSIUM SPARING + THIAZIDE DIURETICS
amiloride/
hydrochloro-
thiazide
5mg/
 
50mg
scored tabs Adults: Initially 1 tab daily with food. May increase to 2 tabs daily in single or divided doses.
Children: Not recommended.
spirono-
lactone/
hydrochloro-
thiazide
Aldactazide 25mg/
 
25mg, 50mg/
 
50mg+
tabs Adults: Usual maintenance: 50−100mg each of spironolactone and HCTZ daily in single or divided doses.
Children: Not established.
triamterene/
hydrochloro-
thiazide
Dyazide 37.5mg/
 
25mg
caps Adults: 1−2 caps once daily
Children: Not recommended.
Maxzide-25mg 37.5mg/
 
25mg
scored tabs Adults: 1−2 tabs daily
Children: Not recommended.
Maxzide 75mg/
 
50mg
scored tabs Adults: 1 tab daily
Children: Not recommended.
THIAZIDE-LIKE DIURETICS
chloro-
thiazide
250mg, 500mg scored tabs Adults: 0.5−1g/day as single or divided doses; max 2g/day.
Children: <6mos: up to 15mg/lb/day in 2 divided doses. ≥6mos: 10mg/lb/day in 2 divided doses.
chlortha-
lidone
25mg, 50mg tabs Adults: Initially 25mg once daily; if needed may increase to 50mg once daily. Maintenance: Doses should be lower than initial doses; individualize.
Children: Not established.
Thalitone 15mg tabs Adults: Initially 15mg once daily; may increase to 30mg and then to a single dose of 45−50mg. Maintenance: Doses may be lower than initial doses; individualize.
Children: Not established.
hydrochloro-
thiazide
25mg, 50mg scored tabs Adults: Initially 25mg once daily; usual max 50mg/day in single or divided doses.
Children: See literature. 1−2mg/kg/day in 1 or 2 divided doses. <6mos: up to 3mg/kg/day in 2 divided doses. ≤2yrs: max 37.5mg/day. 2−12yrs: up to 100mg/day.
Microzide 12.5mg caps Adults: 12.5mg once daily; usual max 50mg/day
Children: Not recommended.
indapamide 1.25mg, 2.5mg tabs Adults: Initially 1.25mg once daily in the AM. May adjust at 4‑wk intervals to 2.5mg then 5mg once daily.
Children: Not recommended.
metolazone Zaroxolyn 2.5mg, 5mg, 10mg tabs Adults: 2.5−5mg once daily
Children: Not recommended.
NOTES

Key: + = scored tablets

(Rev. 10/2014)

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