FDA-Approved Prostate Cancer Treatments

FDA-APPROVED PROSTATE CANCER TREATMENTS
Generic Brand Strength Form Usual Dose
ALKYLATING AGENT
estra-
mustine
Emcyt 140mg caps 14mg/kg in 3 or 4 divided doses
ANTHRACENEDIONE
mitoxan-
trone
2mg/mL soln for IV infusion after dilution 12−14mg/m² every 21 days
ANTIANDROGENS
abiraterone acetate Zytiga 250mg tabs 1g once daily in combination with prednisone 5mg twice daily on an empty stomach
bicalu-
tamide
Casodex 50mg tabs 50mg daily
enzalu-
tamide
Xtandi 40mg caps 160mg once daily
flutamide 125mg caps 250mg every 8hrs
nilutamide Nilandron 150mg tabs 300mg once daily for 30days, then 150mg once daily, starting day of or day after surgical castration
ANTIMICROTUBULE AGENTS
docetaxel Taxotere 40mg/mL soln for IV infusion after dilution 75mg/m² once every 3wks
cabazitaxel Jevtana 60mg/
 
1.5mL
soln for IV infusion after dilution 25mg/m² once every 3wks with oral prednisone 10mg daily during treatment
AUTOLOGOUS CELLULAR IMMUNOTHERAPY
sipuleucel‑T Provenge Minimum 50 million autolo-
gous CD54+ cells activated with PAP-GM-CSF/
250mL dose
susp for IV infusion Autologous use only. Obtain product release from manufacturer, match patient identity on product and Cell Product Disposition form, check expiration date and time on product before infusing. Premedicate 30min before infusion with acetaminophen and antihistamine. Give three doses at 2‑wk intervals. For each dose: Give entire contents of bag by IV infusion over 60min; do not use filter; do not use if clumps do not disperse with gentle mixing. Observe patient for at least 30min after infusion. May interrupt or slow infusion if acute transfusion reaction occurs; do not restart if product at room temp for >3hrs.
ESTROGENS
conjugated estrogens Premarin 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg tabs 1.25−2.5mg 3 times daily
estradiol Estrace 0.5mg, 1mg, 2mg scored tabs 1−2mg 3 times daily
estradiol valerate Delestrogen 10mg/mL, 20mg/mL, 40mg/mL soln for IM inj 30mg or more every 1 or 2wks
estrogens, esterified Menest 0.3mg, 
0.625mg, 1.25mg, 2.5mg
tabs 1.25−2.5mg 3 times daily
GnRH ANALOGUES
goserelin acetate Zoladex 3.6mg SC implant Advanced prostate cancer: One 3.6mg implant every 28 days or one 10.8mg implant every 12wks.
Stage B2-C prostatic carcinoma (in combination with flutamide): Initially one 3.6mg implant, followed in 28 days by one 10.8mg implant; or may use one 3.6mg implant every 28 days. Treat 8wks prior to and during radiotherapy.
Zoladex
3-Month 10.8mg
10.8mg
histrelin acetate Vantas 50mg SC implant Insert 1 implant SC in the inner aspect of the upper arm; remove or replace after 12mos
leuprolide acetate Eligard 7.5mg
1-month
7.5mg ext-rel susp for SC inj 7.5mg SC once per month; or 22.5mg SC once every 3mos; or 30mg SC once every 4mos; or 45mg SC once every 6mos
Eligard 22.5mg 3‑month 22.5mg
Eligard 30mg
4-month
30mg
Eligard 45mg
6-month
45mg
leuprolide acetate Lupron Depot 7.5mg 7.5mg depot susp for IM inj 7.5mg IM once per month; or 22.5mg IM once every 3mos; or 30mg IM once every 4mos; or 45mg IM once every 6mos
Lupron Depot–3month 22.5mg 22.5mg
Lupron Depot–4month 30mg 30mg
Lupron Depot - 6month 45mg 45mg
leuprolide acetate 5mg/mL soln for 
SC inj
1mg SC daily
triptorelin pamoate Trelstar 3.75mg, 11.25mg, 22.5mg pwd for IM inj after reconsti-
tution
3.75mg every 4wks or 11.25mg every 12wks or 22.5mg every 24wks
GnRH ANTAGONIST
degarelix Firmagon 80mg/
 
vial, 120mg/
 
vial
pwd for SC inj after reconsti-
tution
Give by SC inj in abdomen once every 28 days; avoid waist and rib areas. Two 120mg injections once, then one 80mg inj once every 28 days.
NOTES

Not an inclusive list of medications and/or doses. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 8/2014)

Loading links....
You must be a registered member of Renal and Urology News to post a comment.

Sign Up for Free e-newsletters